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Sleep deprivation promotes tumor growth through loss of daily rhythms in cellular lipid metabolism.
Assuntos
Neoplasias , Privação do Sono , Sono , Humanos , Neoplasias/metabolismo , Sono/fisiologia , Animais , Privação do Sono/metabolismo , Privação do Sono/fisiopatologia , Metabolismo dos Lipídeos , Ritmo Circadiano/fisiologiaRESUMO
Opioids trigger myelin insulation of reward circuit axons in a feedforward loop of addiction.
Assuntos
Analgésicos Opioides , Humanos , Analgésicos Opioides/farmacologia , Animais , Axônios/metabolismo , Axônios/fisiologia , Bainha de Mielina/metabolismo , Recompensa , Transtornos Relacionados ao Uso de OpioidesRESUMO
YTHDC1 activates the DNA repair kinase ATR to suppress bleomycin-induced lung fibrosis.
Assuntos
Fibrose Pulmonar , Humanos , Reparo do DNARESUMO
Glia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.
Assuntos
Neuroglia , Sono , Animais , Humanos , Neuroglia/metabolismo , Neuroglia/fisiologia , Sono/fisiologia , Vigília/fisiologiaRESUMO
Astrocyte-secreted neurocan guides the formation of inhibitory circuits in the brain.
Assuntos
Sinapses , Sinapses/fisiologia , Sinapses/metabolismo , Humanos , Animais , Neuroglia/metabolismo , Neuroglia/fisiologia , Neuroglia/citologia , Astrócitos/metabolismo , Astrócitos/citologia , Astrócitos/fisiologia , Neurogênese/fisiologia , Encéfalo/fisiologia , Encéfalo/metabolismoRESUMO
Targeting a driver of TBK1 kinase activity may slow the growth of kidney tumors.
Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Humanos , Proteínas Serina-Treonina Quinases/genética , Proteínas Serina-Treonina Quinases/metabolismo , Fosforilação , Neoplasias Renais/genéticaRESUMO
Blocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.
Assuntos
Doença de Alzheimer , Microglia , Humanos , Neurônios , Transdução de Sinais , SinapsesRESUMO
Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Several studies show that there is still much to learn about cell death mechanisms.
Assuntos
Aprendizagem , Piroptose , Morte CelularRESUMO
Co-targeting glial cells may block the paradoxical increase in pain caused by repeated opioid use.
Assuntos
Analgésicos Opioides , Neuroglia , Humanos , Analgésicos Opioides/efeitos adversos , Dor/induzido quimicamenteRESUMO
A high-protein diet may promote deep sleep by gut secretion of a dopamine neuron-stimulating peptide.