Detalhe da pesquisa
1.
Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.
Bioorg Med Chem
; 27(2): 255-264, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552009
2.
D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.
Bioorg Med Chem Lett
; 26(8): 2088-91, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965861
3.
Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Bioorg Med Chem
; 22(21): 5831-7, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288495
4.
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Biochem Biophys Res Commun
; 438(2): 243-8, 2013 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23850693
5.
Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.
Bioorg Med Chem Lett
; 23(13): 3910-3, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683589
6.
D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II.
Pharmaceutics
; 14(10)2022 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36297453
7.
Inhibition of xcâ» transporter-mediated cystine uptake by sulfasalazine analogs.
Bioorg Med Chem Lett
; 21(20): 6184-7, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21889337
8.
Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020).
Expert Opin Ther Pat
; 31(7): 609-623, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33554679
9.
The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II.
Bioorg Med Chem Lett
; 20(24): 7222-5, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074428
10.
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES).
Biochem J
; 406(3): 407-14, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17581113
11.
δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors.
J Med Chem
; 57(1): 243-7, 2014 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24354364
12.
Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.
ACS Med Chem Lett
; 3(10): 839-843, 2012 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23243487
13.
Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.
J Med Chem
; 55(12): 5922-32, 2012 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22642259
14.
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
J Med Chem
; 55(23): 10551-63, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23151085
15.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Cell Metab
; 15(2): 157-70, 2012 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22326218
16.
Recent advances in the discovery of D-amino acid oxidase inhibitors and their therapeutic utility in schizophrenia.
Curr Pharm Des
; 17(2): 103-11, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21361869
17.
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Cancer Res
; 70(22): 8981-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21045145
18.
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.
J Med Chem
; 53(12): 4561-84, 2010 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20364863