Detalhe da pesquisa
1.
Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics.
Rev Physiol Biochem Pharmacol
; 185: 233-257, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-33649992
2.
Multisystem involvement, defective lysosomes and impaired autophagy in a novel rat model of nephropathic cystinosis.
Hum Mol Genet
; 31(13): 2262-2278, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35137071
3.
OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease.
Hum Mol Genet
; 28(12): 1931-1946, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30590522
4.
Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis.
J Am Soc Nephrol
; 31(7): 1522-1537, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503896
5.
The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.
Kidney Int
; 98(4): 883-896, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32919786
6.
Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants.
Hepatology
; 63(6): 1842-59, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26660341
7.
Microglial cytokines poison neuronal autophagy via CCR5, a druggable target.
Autophagy
; : 1-3, 2023 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37358357
8.
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.
Neuron
; 111(13): 2021-2037.e12, 2023 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37105172
9.
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization.
Nat Commun
; 14(1): 3994, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37452023
10.
The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy.
Curr Opin Pharmacol
; 60: 149-157, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34419832
11.
Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency.
Nat Commun
; 11(1): 970, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32080200
12.
Author Correction: Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency.
Nat Commun
; 11(1): 1719, 2020 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238804
13.
Defective autophagy degradation and abnormal tight junction-associated signaling drive epithelial dysfunction in cystinosis.
Autophagy
; 14(7): 1157-1159, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29806776
14.
Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney.
Nat Commun
; 9(1): 161, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29323117