RESUMO
Chlorine dioxide complex™ is a new molecule to dermatology that is a unique, non-toxic, broad spectrum anti-microbial and keratolytic compound. Chlorine dioxide has been used as an antiseptic in industrial settings for decades, primarily in water treatment facilities for municipal water supplies and food preparation. The compound has exceptional antiseptic properties with no known potential for development of resistance. It is a true keratolytic and anti-inflammatory, but is non-toxic to human tissue due to its unique mechanism of action. Chlorine dioxide's use in consumer products was previously limited because it is inherently an unstable molecule that had to be used quickly after it was produced. However, the recent development of a complexed form of chlorine dioxide that retains its antimicrobial and keratolytic activity has allowed the development of products (AsepticMD, Aseptic Plus, Nashville, TN) that take advantage of the properties of this unique molecule. Here we report a case series demonstrating its efficacy as a cleanser in keratosis pilaris. J Drugs Dermatol. 2018;17(5):554-556.
Assuntos
Anormalidades Múltiplas/tratamento farmacológico , Compostos Clorados/uso terapêutico , Doença de Darier/tratamento farmacológico , Detergentes/uso terapêutico , Sobrancelhas/anormalidades , Óxidos/uso terapêutico , Anormalidades Múltiplas/patologia , Adolescente , Adulto , Criança , Compostos Clorados/administração & dosagem , Doença de Darier/patologia , Detergentes/administração & dosagem , Sobrancelhas/patologia , Feminino , Humanos , Masculino , Óxidos/administração & dosagem , Resultado do Tratamento , Adulto JovemAssuntos
Síndrome de Cushing/tratamento farmacológico , Sarcoidose/diagnóstico , Adulto , Antibacterianos/uso terapêutico , Quimioterapia Combinada , Feminino , Pé/patologia , Glucocorticoides/uso terapêutico , Mãos/patologia , Humanos , Minociclina/uso terapêutico , Iodeto de Potássio/administração & dosagem , Iodeto de Potássio/uso terapêutico , Prednisolona/uso terapêutico , Sarcoidose/tratamento farmacológico , Sarcoidose/patologiaAssuntos
Dermatoses Faciais/parasitologia , Infestações por Ácaros/patologia , Administração Cutânea , Idoso , Idoso de 80 Anos ou mais , Antiparasitários/uso terapêutico , Dermatoses Faciais/tratamento farmacológico , Feminino , Humanos , Metronidazol/uso terapêutico , Infestações por Ácaros/tratamento farmacológicoRESUMO
Argininosuccinicaciduria is a rare metabolic disorder of the urea cycle associated with the inability to excrete nitrogenous waste in the form of urea. Along with low serum arginine, hepatomegaly, and mental retardation, congenital trichorrhexis nodosa is a distinguishing feature of the disorder. We present a 3.5-year-old girl diagnosed with argininosuccinicaciduria who presented to the dermatology clinic with hair thinning and loss since birth. Microscopic evaluation revealed nodular swellings on the hair shafts and frayed cortical fibers consistent with the diagnosis of trichorrhexis nodosa occurring in the setting of argininosuccinicaciduria.