Detalhe da pesquisa
1.
Bidirectional transport of amino acids regulates mTOR and autophagy.
Cell
; 136(3): 521-34, 2009 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19203585
2.
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Mol Cell
; 47(4): 535-46, 2012 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22795129
3.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Nature
; 485(7397): 195-200, 2012 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22575959
4.
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Mol Cell
; 39(2): 171-83, 2010 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20670887
5.
Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.
Nat Chem Biol
; 10(5): 343-9, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24633354
6.
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Nature
; 468(7326): 968-72, 2010 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21107320
7.
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Nature
; 461(7264): 614-20, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19759537
8.
Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
Eur J Immunol
; 42(12): 3394-404, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22930133
9.
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.
Proc Natl Acad Sci U S A
; 107(35): 15473-8, 2010 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-20713706
10.
Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.
Mol Cancer Res
; 6(4): 614-23, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18403640
11.
Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.
ACS Med Chem Lett
; 7(1): 72-6, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819669
12.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nat Cell Biol
; 16(11): 1069-79, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25327288
13.
Defective autophagy and mTORC1 signaling in myotubularin null mice.
Mol Cell Biol
; 33(1): 98-110, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23109424
14.
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.
Chem Biol
; 20(7): 912-21, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23890009
15.
RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth.
PLoS One
; 7(11): e48548, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23155392
16.
Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.
Cancer Discov
; 2(10): 948-59, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22874768
17.
Relieving autophagy and 4EBP1 from rapamycin resistance.
Mol Cell Biol
; 31(14): 2867-76, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21576371
18.
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Nat Cell Biol
; 13(5): 623-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21478859