Detalhe da pesquisa
1.
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.
Bioorg Med Chem Lett
; 28(23-24): 3780-3783, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30337231
2.
Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.
Bioorg Med Chem Lett
; 24(9): 2053-6, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726802
3.
Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.
Bioorg Med Chem Lett
; 24(9): 2057-61, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726803
4.
A novel series of pyrazolylpiperidine N-type calcium channel blockers.
Bioorg Med Chem Lett
; 22(12): 4080-3, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22608964
5.
Optimization of a High-Throughput Cell-Based Screening Strategy to Identify Small-Molecule Inhibitors of IL-23 Signaling.
SLAS Discov
; 26(1): 122-129, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32484379
6.
The core membrane fusion complex governs the probability of synaptic vesicle fusion but not transmitter release kinetics.
J Neurosci
; 22(4): 1266-72, 2002 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11850454
7.
High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays.
J Biomol Screen
; 20(6): 708-19, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25700884
8.
SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission.
Neuropharmacology
; 45(6): 857-62, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14529723
9.
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
J Med Chem
; 56(22): 9019-30, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24205976
10.
An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists.
Assay Drug Dev Technol
; 8(6): 685-94, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21050074
11.
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
J Med Chem
; 52(23): 7528-36, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19388676