Detalhe da pesquisa
1.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24226772
2.
Creating a more strategic small molecule biophysical hit characterization workflow.
SLAS Discov
; 29(4): 100159, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38723666
3.
The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.
Bioorg Med Chem Lett
; 23(23): 6396-400, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24120542
4.
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.
Bioorg Med Chem Lett
; 23(24): 6625-8, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215889
5.
Quinolinone-based agonists of S1P1: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Bioorg Med Chem Lett
; 22(1): 527-31, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22104144
6.
Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.
J Pharmacol Exp Ther
; 337(3): 681-91, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21422163
7.
Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.
Bioorg Med Chem Lett
; 21(18): 5191-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21824779
8.
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation.
Bioorg Med Chem Lett
; 21(11): 3384-9, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21514825
9.
Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
Chem Res Toxicol
; 23(3): 653-63, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20095585
10.
Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett
; 20(15): 4593-7, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20573508
11.
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg Med Chem Lett
; 20(5): 1559-64, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137943
12.
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
Bioorg Med Chem Lett
; 20(18): 5544-7, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20708930
13.
Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.
J Med Chem
; 63(20): 11602-11614, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32965113
14.
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
J Med Chem
; 51(10): 2933-43, 2008 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18419108
15.
Calcium sensing receptor activators: calcimimetics.
Curr Med Chem
; 14(28): 3027-34, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220738
16.
2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
J Med Chem
; 50(3): 429-32, 2007 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17266194
17.
Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.
J Med Chem
; 50(15): 3497-514, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17585749
18.
Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate.
J Med Chem
; 50(15): 3515-27, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17585750
19.
Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity.
J Med Chem
; 50(4): 607-10, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17243660
20.
Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.
J Med Chem
; 50(9): 2200-12, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17408249