Detalhe da pesquisa
1.
Regiodivergent Nucleophilic Fluorination under Hydrogen Bonding Catalysis: A Computational and Experimental Study.
J Am Chem Soc
; 145(17): 9708-9717, 2023 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37079853
2.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J Chem Inf Model
; 63(9): 2828-2841, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37060320
3.
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Mol Hum Reprod
; 27(9)2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463764
4.
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration.
Biol Reprod
; 103(2): 176-182, 2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32307523
5.
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
J Chem Inf Model
; 64(3): 1106, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258980
6.
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.
Bioorg Med Chem
; 24(16): 3447-55, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27301679
7.
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
J Med Chem
; 65(22): 15208-15226, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36346696
8.
Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
J Med Chem
; 64(2): 1103-1115, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33404239
9.
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS Med Chem Lett
; 12(8): 1283-1287, 2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413957
10.
Catalytic enantioselective 1,3-dipolar cycloadditions of nitrones with propioloylpyrazoles and acryloylpyrazoles induced by chiral π-cation catalysts.
J Am Chem Soc
; 132(44): 15550-2, 2010 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20958041
11.
T-495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointestinal side effect risk.
Pharmacol Res Perspect
; 8(1): e00560, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31990455
12.
Prediction of Compound Bioactivities Using Heat-Diffusion Equation.
Patterns (N Y)
; 1(9): 100140, 2020 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33336198
13.
Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
J Med Chem
; 62(10): 4915-4935, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31009559
14.
Catalytic enantioselective [2 + 4] and [2 + 2] cycloaddition reactions with propiolamides.
J Am Chem Soc
; 130(24): 7532-3, 2008 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18494473
15.
Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: octahydro-1H-indole carboxylates.
J Org Chem
; 73(19): 7807-10, 2008 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18767800
16.
Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.
J Med Chem
; 61(20): 9205-9217, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30251836
17.
Design of a small-molecule catalyst using intramolecular cation-pi interactions for enantioselective Diels-Alder and Mukaiyama-Michael reactions: L-DOPA-derived monopeptide.Cu(II) complex.
Org Lett
; 8(9): 1921-4, 2006 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16623585
18.
Design of Brønsted acid-assisted chiral Brønsted acid catalyst bearing a bis(triflyl)methyl group for a Mannich-type reaction.
Org Lett
; 8(15): 3175-8, 2006 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16836359
19.
Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J Med Chem
; 57(22): 9627-43, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25384088
20.
Rational design of minimal artificial Diels-Alderases based on the copper(II) cation-aromatic pi attractive interaction.
Acc Chem Res
; 40(10): 1049-55, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17661439