Ultrasound-based "CEUS-Bosniak"classification for cystic renal lesions: an 8-year clinical experience.

PURPOSE: Renal cysts comprise benign and malignant entities. Risk assessment profits from CT/MRI imaging using the Bosniak classification. While Bosniak-IIF, -III, and -IV cover complex cyst variants, Bosniak-IIF and -III stand out due to notorious overestimation. Contrast-enhanced ultrasound (CEUS) is promising to overcome this deficit but warrants standardization. This study addresses the benefits of a combined CEUS and CT/MRI evaluation of renal cysts. The study provides a realistic account of kidney tumor boards' intricacies in trying to validate renal cysts. METHODS: 247 patients were examined over 8 years. CEUS lesions were graded according to CEUS-Bosniak (IIF, III, IV). 55 lesions were resected, CEUS-Bosniak- and CT/MRI-Bosniak-classification were correlated with histopathological diagnosis. Interobserver agreement between the classifications was evaluated statistically. 105 lesions were followed by ultrasound, and change in CEUS-Bosniak-types and lesion size were documented. RESULTS: 146 patients (156 lesions) were included. CEUS classified 67 lesions as CEUS-Bosniak-IIF, 44 as CEUS-Bosniak-III, and 45 as CEUS-Bosniak-IV. Histopathology of 55 resected lesions revealed benign cysts in all CEUS-Bosniak-IIF lesions (2/2), 40% of CEUS-Bosniak-III and 8% of CEUS-Bosniak-IV, whereas malignancy was uncovered in 60% of CEUS-Bosniak-III and 92% of CEUS-Bosniak-IV. Overall, CEUS-Bosniak-types matched CT/MRI-Bosniak types in 58% (fair agreement, κ = 0.28). CEUS-Bosniak resulted in higher stages than CT/MRI-Bosniak (40%). Ultrasound follow-up of 105 lesions detected no relevant differences between CEUS-Bosniak-types concerning cysts size. 99% of lesions showed the same CEUS-Bosniak-type. CONCLUSION: The CEUS-Bosniak classification is an essential tool in clinical practice to differentiate and monitor renal cystic lesions and empowers diagnostic work-up and patient care.

Factors related to postoperative discomfort in young children following dental rehabilitation under general anesthesia.

PURPOSE: This study, conducted in ambulatory surgical centers, was a response to queries from pediatric dentists who wondered if postoperative discomfort in their patients treated for early childhood caries under general anesthesia was related to specific dental procedures. The purpose of this study was to identify factors related to the occurrence and severity of postoperative discomfort. METHODS: Subjects were children younger than 7 years old. The faces, legs, activity, cry, consolability pain assessment tool measured discomfort immediately postoperatively; the dental discomfort questionnaire (DDQ-8) measured discomfort preoperatively and after treatment. Data was analyzed with bivariate tests and hierarchical linear multiple regression. RESULTS: Of the 160 participants (52.9±15.0 months old), approximately 51% had preoperative dental discomfort (DDQ-8 score=>3). The proportion with discomfort had significantly decreased to 27% by days 2 to 5. Immediate discomfort in recovery was influenced by number of crowns and space maintainers and inversely by the length of postoperative sleep. Dental discomfort in the first week postoperatively was predicted by amount of preoperative discomfort, length of sleep in recovery, and not resuming a regular diet on Day 1. CONCLUSION: In these children, discomfort after treatment was mild, decreased over time, and, other than immediately postoperatively, was not related to specific dental procedures.