Detalhe da pesquisa
1.
Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases.
J Pharmacol Exp Ther
; 368(3): 446-461, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622172
2.
Brain Distributional Kinetics of a Novel MDM2 Inhibitor SAR405838: Implications for Use in Brain Tumor Therapy.
Drug Metab Dispos
; 47(12): 1403-1414, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31619389
3.
Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.
Drug Metab Dispos
; 47(10): 1122-1135, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266753
4.
E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases.
Invest New Drugs
; 37(4): 636-645, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30264293
5.
Brain Distribution of a Novel MEK Inhibitor E6201: Implications in the Treatment of Melanoma Brain Metastases.
Drug Metab Dispos
; 46(5): 658-666, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29437873
6.
Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine.
Pharm Res
; 35(9): 177, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30003344
7.
Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?
Pharmacol Res
; 123: 10-25, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28634084
8.
Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.
Br J Pharmacol
; 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486310
9.
Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.
Neuro Oncol
; 24(3): 384-395, 2022 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34232318
10.
In Vivo Efficacy of Tesevatinib in EGFR-Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory Signaling.
Mol Cancer Ther
; 20(6): 1009-1018, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785646
11.
Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma.
Sci Rep
; 10(1): 6524, 2020 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32300151
12.
Challenges in the delivery of therapies to melanoma brain metastases.
Curr Pharmacol Rep
; 2(6): 309-325, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28546917