Detalhe da pesquisa
1.
A Phase I, First-in-Human Study of GSK2849330, an Anti-HER3 Monoclonal Antibody, in HER3-Expressing Solid Tumors.
Oncologist
; 26(10): e1844-e1853, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34132450
2.
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Nature
; 492(7427): 108-12, 2012 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23051747
3.
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Proc Natl Acad Sci U S A
; 109(8): 2989-94, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22323599
4.
Novel Preclinical Patient-Derived Lung Cancer Models Reveal Inhibition of HER3 and MTOR Signaling as Therapeutic Strategies for NRG1 Fusion-Positive Cancers.
J Thorac Oncol
; 16(7): 1149-1165, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33839363
5.
A Phase I, Open-Label, Dose-Finding Study of GSK2636771, a PI3Kß Inhibitor, Administered with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer.
Clin Cancer Res
; 27(19): 5248-5257, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34281912
6.
Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers.
Cancer Discov
; 8(6): 686-695, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29610121
7.
A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 23(19): 5981-5992, 2017 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28645941
8.
Integration of genomic and metabonomic data in systems biology--are we 'there' yet?
Curr Opin Drug Discov Devel
; 9(1): 92-100, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16445121
9.
Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230.
Oncotarget
; 7(26): 39861-39871, 2016 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27223434
10.
WIP1 phosphatase as a potential therapeutic target in neuroblastoma.
PLoS One
; 10(2): e0115635, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25658463
11.
BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models.
PLoS One
; 8(8): e72967, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24009722
12.
Systems biology and the host response to viral infection.
Nat Biotechnol
; 25(12): 1383-9, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18066032