[Clinical analysis of adverse reactions in patients with multidrug-resistant and rifampicin-resistant pulmonary tuberculosis treated with delamanid-containing regimen].

Objective: To explore the characteristics of adverse drug reactions during the 24-week therapy with delamanid-containing regimen for patients with multidrug-resistant and rifampicin-resistant pulmonary tuberculosis (MDR/RR-PTB). Methods: The prospective multicenter study was conducted from June 2020 to June 2023. A total of 608 eligible patients with MDR/RR-PTB were enrolled in 26 tuberculosis medical institutions in China including 364 males and 79 females, aged 39.6(19.0-68.0) years. Patients were treated with chemotherapy regimens containing delamanid. Patients were closely supervised during treatment of medication, and all adverse reactions occurring during treatment were monitored and recorded. The clinical characteristics of adverse reactions were evaluated by descriptive analysis. Chi-square test and multivariate logistic regression were used to analyze the related factors of QTcF interval prolongation (QT corrected with Fridericia's formula). Results: Of the 608 patients enrolled in this study, 325 patients (53.5%) reported 710 adverse events within 24 weeks of treatment. The top 6 most common complications were hematological abnormalities (143 patients, 23.5%), QT prolongation (114 patients, 18.8%), liver toxicity (85 patients, 14.0%), gastrointestinal reaction (41 patients, 6.7%), peripheral neuropathy (25 patients, 4.1%) and mental disorders (21 patients, 3.5%). The prolongation of QT interval mostly occurred in the 12th week after the first dose of medication. Serious adverse reactions occurred in 21 patients (3.5%). There were 7 patients (1.2%) with mental disorders, including 2 patients (0.3%) with severe mental disorders. Conclusions: The safety of dalamanid-based regimen in the staged treatment of MDR/RR-PTB patients was generally good, and the incidence of adverse reactions was similar to that reported in foreign studies. This study found that the incidence of QT interval prolongation in Chinese patients was higher than that reported overseas, suggesting that the monitoring of electrocardiogram should be strengthened when using drugs containing delamanid that may cause QT interval prolongation.

[The tuberculosis sanitariums during era of the Republic of China].

The quarantine and treatment plays an important role in prevention and control of respiratory infectious diseases. It has been nearly 200 years since sanatorium model was adopted to isolate and treat patients with tuberculosis(TB). The era of the Republic of China was an important period for the model to sprout and expand. TB sanatorium was established in the early 20th century in China, and flourished in the 1930s. Establishment and changes of TB sanatoriums in Peking, Shanghai and Hangzhou during the era of the Republic of China, has great significance for sorting out the clues of China's anti-TB history, exploring historical trends of TB in China, and most important of all, summing up valuable lessons.

[Treatment of 36 corticosteroid-dependent type of aspirin asthma patients with Glucosidorum Tripterygii totorum].

This paper reports that substitution of Glucosidorum Tripterygii Totorum (GTT) for cortical hormone used to treat corticosteroid-dependent type of aspirin asthma, 60 mg, 3 times a day. The result showed that total effective rate was 100% including 31 cases of marked effective (86.11%) and 5 cases of effective (13.89%). Corticosteroid in the blood was significantly elevated to normal level after treatment (P < 0.001), Cushing's syndrome was cleared up gradually. The blood glucose in 9 cases complicated with diabetes mellitus was recovered and glucosuria test was negative. The value of peak expiratory flow (PEF) was increased to some extent (P of male < 0.01, of female < 0.05), especially on those not complicated with emphysema. There was no side-effect during the treatment and could avoid the side-effect of cortical hormone. This therapy was valuable.

[Protective effect of fructus gardeniae on pancreatic subcellular organs of the acute pancreatitis in rats].

The acute pancreatitis (AP) was induced with sodium deoxy-cholate in SD rats. Succinic dehydrogenase (SDH), acid phosphatase (ACP) and cytochrome P450 were taken as marked enzyme in estimation of mitochondria, lysosome and microsome to observe the functional and structural changes of the pancreatic subcellular organs and the protective effects of Fructus Gardeniae (FG) in acute pancreatitis in rats. The histological change was observed simultaneously. The results showed that pancreatic cellular SDH reduced significantly and the releasing rate of ACP raised obviously in AP, in FG treated group, SDH was nearly the same as in normal, the releasing rate of ACP decreased and the content of P450 increased in the same time. Histologic observation showed that there was significant inflammatory change in pancreas and abnormal manifestation in structure of subcellular organs in AP, FG Could alleviate the lesion. These results suggested the FG has a remarkable protective effect on the function and structure of the pancreatic subcellular organs in AP.

[Determination of catechins in grape seeds by capillary electrophoresis].

A capillary zone electrophoresis (CZE) method has been developed for the determination of four pharmacologically active catechins in grape seed. The components analyzed were (+)-catechin, (-)-epicatechin, epigallocatechin and epicatechin gallate. Separation was achieved by using a mixed buffer of 0.02 mol/L borate and 0.005 mol/L phosphate at pH 10.0 as background electrolyte and an uncoated fused silica capillary with 50 microns i.d. x 375 microns o.d. (effective length 41.5 cm) maintained at 25 degrees C. The applied voltage was 25 kV, and detection was performed by DAD at wavelength of 210 nm. By using proposed CZE method, four catechins were well separated within only 10 minutes with the repeatability of < 1% RSD for migration time and < 5% RSD for peak area. Correlation coefficients better than 0.995 were obtained within the concentration range from 0.005 g/L to 0.5 g/L for the four analytes studied with the detection limit of 3 mg/L-10 mg/L. The contents of these compounds in ten species of grape seeds cultivated in China were successfully determined.