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1.
Proc Natl Acad Sci U S A ; 120(3): e2216024120, 2023 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-36623188

RESUMO

Seagrasses provide multiple ecosystem services and act as intense carbon sinks in coastal regions around the globe but are threatened by multiple anthropogenic pressures, leading to enhanced seagrass mortality that reflects in the spatial self-organization of the meadows. Spontaneous spatial vegetation patterns appear in such different ecosystems as drylands, peatlands, salt marshes, or seagrass meadows, and the mechanisms behind this phenomenon are still an open question in many cases. Here, we report on the formation of vegetation traveling pulses creating complex spatiotemporal patterns and rings in Mediterranean seagrass meadows. We show that these structures emerge due to an excitable behavior resulting from the coupled dynamics of vegetation and porewater hydrogen sulfide, toxic to seagrass, in the sediment. The resulting spatiotemporal patterns resemble those formed in other physical, chemical, and biological excitable media, but on a much larger scale. Based on theory, we derive a model that reproduces the observed seascapes and predicts the annihilation of these circular structures as they collide, a distinctive feature of excitable pulses. We show also that the patterns in field images and the empirically resolved radial profiles of vegetation density and sediment sulfide concentration across the structures are consistent with predictions from the theoretical model, which shows these structures to have diagnostic value, acting as a harbinger of the terminal state of the seagrass meadows prior to their collapse.


Assuntos
Ecossistema , Modelos Teóricos , Áreas Alagadas , Sequestro de Carbono , Sulfetos
2.
Phys Rev Lett ; 130(5): 058401, 2023 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-36800461

RESUMO

We identify a mechanism for biological spatial pattern formation arising when the signals that mediate interactions between individuals in a population have pulsed character. Our general population-signal framework shows that while for a slow signal-dynamics limit no pattern formation is observed for any values of the model parameters, for a fast limit, on the contrary, pattern formation can occur. Furthermore, at these limits, our framework reduces, respectively, to reaction-diffusion and spatially nonlocal models, thus bridging these approaches.


Assuntos
Modelos Biológicos , Humanos , Difusão
3.
Sensors (Basel) ; 23(7)2023 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-37050477

RESUMO

In this work, a decentralized but synchronized real-world system for smart battery management was designed by using a general controller with cloud computing capability, four charge regulators, and a set of sensorized battery monitors with networking and Bluetooth capabilities. Currently, for real-world applications, battery management systems (BMSs) can be used in the form of distributed control systems where general controllers, charge regulators, and smart monitors and sensors are integrated, such as those proposed in this work, which allow more precise estimations of a large set of important parameters, such as the state of charge (SOC), state of health (SOH), current, voltage, and temperature, seeking the safety and the extension of the useful life of energy storage systems based on battery banks. The system used is a paradigmatic real-world example of the so-called intelligent battery management systems. One of the contributions made in this work is the realization of a distributed design of a BMS, which adds the benefit of increased system security compared to a fully centralized BMS structure. Another research contribution made in this work is the development of a methodical modeling procedure based on Petri Nets, which establishes, in a visible, organized, and precise way, the set of conditions that will determine the operation of the BMS. If this modeling is not carried out, the threshold values and their conditions remain scattered, not very transparent, and difficult to deal with in an aggregate way.

4.
Sensors (Basel) ; 23(3)2023 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-36772354

RESUMO

In large solar farms, supervision is an exhaustive task, often carried out manually by field technicians. Over time, automated or semi-automated fault detection and prevention methods in large photovoltaic plants are becoming increasingly common. The same does not apply when talking about small or medium-sized installations, where the cost of supervision at such level would mean total economic infeasibility. Although there are prevention protocols by suppliers, periodic inspections of the facilities by technicians do not ensure that faults such as the appearance of hot-spots are detected in time. That is why, nowadays, the only way of continuous supervision of a small or medium installation is often carried out by unqualified people and in a purely visual way. In this work, the development of a low-cost system prototype is proposed for the supervision of a medium or small photovoltaic installation based on the acquisition and treatment of thermographic images, with the aim of investigating the feasibility of an actual implementation. The work focuses on the system's ability to detect hot-spots in supervised panels and successfully report detected faults. To achieve this goal, a low-cost thermal imaging camera is used for development, applying common image processing techniques, operating with OpenCV and MATLAB R2021b libraries. In this way, it is possible to demonstrate that it is achievable to successfully detect the hottest points of a photovoltaic (PV) installation with a much cheaper camera than the cameras used in today's thermographic inspections, opening up the possibilities of creating a fully developed low-cost thermographic surveillance system.

5.
J Clin Rheumatol ; 29(3): 113-117, 2023 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-36326708

RESUMO

OBJECTIVE: We aimed to assess the use of framework and corresponding methodology to document syndemics and its impact in rheumatic and musculoskeletal diseases (RMDs). METHODS: Using a mixed-methods systematic review, studies using the syndemic framework approach for RMDs were identified and published from January 2003 to January 2021. The Joanna Briggs Institute, Cochrane Collaboration, and PRISMA guidelines were followed to search, retrieve, revise, and analyze. RESULTS: A total of 658 potential articles were identified, but only 10 were initially eligible. After a full-text review, 4 were included. Following a full-text review, 2 quantitative, 1 qualitative, and 1 mixed-methods study were included. In the first, network analysis found that RMDs were associated with comorbidities, unhealthy habits, low educational level, living in rural areas, socioeconomic conditions, and health inequality in indigenous communities. In the second, SSEM and cluster analysis demonstrated an association between low back pain and factors, such as comorbidities and indigenous status, among others, in urban/rural communities. The qualitative study examined 3 fishing family generations and reported less syndemic vulnerability. The mixed-methods study focused on osteoarthritis with multimorbidities in African American population, where lack of education added to worsening outcomes. CONCLUSIONS: Even though the insights syndemic studies have given to other areas, its use in rheumatology is scarce. The complexity of the clinical and social determinants related to RMDs makes it necessary to conduct further studies from a syndemic perspective.


Assuntos
Doenças Musculoesqueléticas , Reumatologia , Humanos , Disparidades nos Níveis de Saúde , Sindemia
6.
Sensors (Basel) ; 22(13)2022 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-35808498

RESUMO

Robotics has been successfully applied in the design of collaborative robots for assistance to people with motor disabilities. However, man-machine interaction is difficult for those who suffer severe motor disabilities. The aim of this study was to test the feasibility of a low-cost robotic arm control system with an EEG-based brain-computer interface (BCI). The BCI system relays on the Steady State Visually Evoked Potentials (SSVEP) paradigm. A cross-platform application was obtained in C++. This C++ platform, together with the open-source software Openvibe was used to control a Stäubli robot arm model TX60. Communication between Openvibe and the robot was carried out through the Virtual Reality Peripheral Network (VRPN) protocol. EEG signals were acquired with the 8-channel Enobio amplifier from Neuroelectrics. For the processing of the EEG signals, Common Spatial Pattern (CSP) filters and a Linear Discriminant Analysis classifier (LDA) were used. Five healthy subjects tried the BCI. This work allowed the communication and integration of a well-known BCI development platform such as Openvibe with the specific control software of a robot arm such as Stäubli TX60 using the VRPN protocol. It can be concluded from this study that it is possible to control the robotic arm with an SSVEP-based BCI with a reduced number of dry electrodes to facilitate the use of the system.


Assuntos
Interfaces Cérebro-Computador , Robótica , Eletroencefalografia/métodos , Potenciais Evocados , Potenciais Evocados Visuais , Humanos , Estimulação Luminosa , Software
7.
Sensors (Basel) ; 22(20)2022 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-36298169

RESUMO

In this work, new results are presented on the implementation of predictive diagnosis techniques on isolated photovoltaic (PV) systems and installations. The novelties introduced in this research focus on the additional advantages obtained from the point of view of predictive diagnosis of faults caused by partial shading in isolated PV installations using maximum power point tracking (MPPT) regulators. MPPT regulators are comparatively more appropriate than pulse width modulation (PWM) solar regulators in order to implement fault diagnosis systems. MPPT regulators have a physical separation between the electrical parameters belonging to the part of the solar panel with respect to the batteries part. Therefore, these electrical parameters can be used to obtain early predictive symptoms of the effects of partial shading with a greater level of observation and sensitivity. Additionally, modifications are proposed in the PV system assembly to obtain greater homogeneity of all the panels regarding the solar irradiance reception angle.


Assuntos
Energia Solar , Simulação por Computador , Fontes de Energia Elétrica , Eletricidade , Luz Solar
8.
Sensors (Basel) ; 22(1)2022 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-35009874

RESUMO

This work proposes a method for real-time supervision and predictive fault diagnosis applicable to solar panel strings in real-world installations. It is focused on the detection and parametric isolation of fault symptoms through the analysis of the Voc-Isc curves. The method performs early, systematic, online, automatic, permanent predictive supervision, and diagnosis of a high sampling frequency. It is based on the supervision of predictive electrical parameters easily accessible by the design of its architecture, whose detection and isolation precedes with an adequate margin of maneuver, to be able to alert and stop by means of automatic disconnection the degradation phenomenon and its cumulative effect causing the development of a future irrecoverable failure. Its architecture design is scalable and integrable in conventional photovoltaic installations. It emphasizes the use of low-cost technology such as the ESP8266 module, ASC712-5A, and FZ0430 sensors and relay modules. The method is based on data acquisition with the ESP8266 module, which is sent over the internet to the computer where a SCADA system (iFIX V6.5) is installed, using the Modbus TCP/IP and OPC communication protocols. Detection thresholds are initially obtained experimentally by applying inductive shading methods on specific solar panels.

9.
Sensors (Basel) ; 22(6)2022 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-35336344

RESUMO

In this paper, an application for the management and supervision by predictive fault diagnosis (PFD) of solar power generation systems is developed through a National Marine Electronics Association (NMEA) 2000 smart sensor network. Here, the NMEA 2000 network sensor devices for measuring and supervising the parameters inherent to solar power generation and renewable energy supply are applied. The importance of renewable power generation systems in ships is discussed, as well as the causes of photovoltaic modules (PVMs) aging due to superimposed causes of degradation, which is a natural and inexorable phenomenon that affects photovoltaic installations in a special way. In ships, PVMs are doubly exposed to inclement weather (solar radiation, cold, rain, dust, humidity, snow, wind, electrical storms, etc.), pollution, and a particularly aggressive environment in terms of corrosion. PFD techniques for the real-world installation and safe navigation of PVMs are discussed. A specific method based on the online analysis of the time-series data of random and seasonal I-V parameters is proposed for the comparative trend analyses of solar power generation. The objective is to apply PFD using as predictor symptom parameter (PS) the generated power decrease in affected PVMs. This PFD method allows early fault detection and isolation, whose appearance precedes by an adequate margin of maneuver, from the point of view of maintenance tasks applications. This early detection can stop the cumulative degradation phenomenon that causes the development of the most frequent and dangerous failure modes of solar modules, such as hot-spots. It is concluded that these failure modes can be conveniently diagnosed by performing comparative trend analyses of the measured power parameters by NMEA sensors.


Assuntos
Navios , Energia Solar , Poluição Ambiental , Energia Renovável , Vento
10.
Sensors (Basel) ; 22(16)2022 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-36015769

RESUMO

A Microgrid (MG), like any other smart and interoperable power system, requires device-to-device (D2D) communication structures in order to function effectively. This communication system, however, is not immune to intentional or unintentional failures. This paper discusses the effects of communication link failures on MG control and management and proposes solutions based on enhancing message content to mitigate their detritus impact. In order to achieve this goal, generation and consumption forecasting using deep learning (DL) methods at the next time steps is used. The architecture of an energy management system (EMS) and an energy storage system (ESS) that are able to operate in coordination is introduced and evaluated by simulation tests, which show promising results and illustrate the efficacy of the proposed methods. It is important to mention that, in this paper, three dissimilar topics namely MG control/management, DL-based forecasting, and D2D communication architectures are employed and this combination is proven to be capable of achieving the aforesaid objective.


Assuntos
Aprendizado Profundo , Comunicação , Simulação por Computador , Previsões
11.
Chaos ; 31(9): 093128, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34598473

RESUMO

In the past few decades, boreal summers have been characterized by an increasing number of extreme weather events in the Northern Hemisphere extratropics, including persistent heat waves, droughts and heavy rainfall events with significant social, economic, and environmental impacts. Many of these events have been associated with the presence of anomalous large-scale atmospheric circulation patterns, in particular, persistent blocking situations, i.e., nearly stationary spatial patterns of air pressure. To contribute to a better understanding of the emergence and dynamical properties of such situations, we construct complex networks representing the atmospheric circulation based on Lagrangian trajectory data of passive tracers advected within the atmospheric flow. For these Lagrangian flow networks, we study the spatial patterns of selected node properties prior to, during, and after different atmospheric blocking events in Northern Hemisphere summer. We highlight the specific network characteristics associated with the sequence of strong blocking episodes over Europe during summer 2010 as an illustrative example. Our results demonstrate the ability of the node degree, entropy, and harmonic closeness centrality based on outgoing links to trace important spatiotemporal characteristics of atmospheric blocking events. In particular, all three measures capture the effective separation of the stationary pressure cell forming the blocking high from the normal westerly flow and the deviation of the main atmospheric currents around it. Our results suggest the utility of further exploiting the Lagrangian flow network approach to atmospheric circulation in future targeted diagnostic and prognostic studies.

12.
Rheumatol Int ; 40(11): 1817-1823, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32588190

RESUMO

In Spain, the QUANTUM project has been promoted to reduce variability in clinical practice and improve the care and quality of life of people with psoriatic arthritis (PsA) by accrediting PsA units throughout the Spanish national health system. To present the results of this approach which sought to ensure an optimum level of quality for patients with PsA. Descriptive analysis of the self-assessments that the PsA units have carried out assessing their degree of compliance with the quality standards established in the QUANTUM project grouped into four blocks: shortening time to diagnosis; optimizing disease management; improving multidisciplinary collaboration; and improving patient monitoring. A total of 41 PsA units were self-evaluated. They met 64.1% of the defined quality standards. Optimize disease management obtained a higher level of standards compliance (72%) and improve multidisciplinary collaboration the lesser (63.9%). Accessibility to the treatments available for PsA in all hospitals was guaranteed (100%). Appropriate diagnostic equipment is available (97.6%). Compliance with specific quality standards leads to detect actions that should be implemented: quality of life assessment (9.8%), locomotor system assessment (12.2%), physical examination data record (14.6%), periodic cardiovascular risk assessment (17.1%). The QUANTUM project results make it possible to visualise how to care for patients with PsA is being developed in Spain. Problems identified in recent multinational reports are also identified in Spain.


Assuntos
Acreditação , Artrite Psoriásica/terapia , Fidelidade a Diretrizes , Guias de Prática Clínica como Assunto , Melhoria de Qualidade , Padrão de Cuidado , Gerenciamento Clínico , Humanos , Qualidade da Assistência à Saúde , Espanha
13.
Sensors (Basel) ; 21(1)2020 Dec 27.
Artigo em Inglês | MEDLINE | ID: mdl-33375441

RESUMO

Brain-computer interfaces (BCI) can extract information about the subject's intentions by registering and processing electroencephalographic (EEG) signals to generate actions on physical systems. Steady-state visual-evoked potentials (SSVEP) are produced when the subject stares at flashing visual stimuli. By means of spectral analysis and by measuring the signal-to-noise ratio (SNR) of its harmonic contents, the observed stimulus can be identified. Stimulus color matters, and some authors have proposed red because of its ability to capture attention, while others refuse it because it might induce epileptic seizures. Green has also been proposed and it is claimed that white may generate the best signals. Regarding frequency, middle frequencies are claimed to produce the best SNR, although high frequencies have not been thoroughly studied, and might be advantageous due to the lower spontaneous cerebral activity in this frequency band. Here, we show white, red, and green stimuli, at three frequencies: 5 (low), 12 (middle), and 30 (high) Hz to 42 subjects, and compare them in order to find which one can produce the best SNR. We aim to know if the response to white is as strong as the one to red, and also if the response to high frequency is as strong as the one triggered by lower frequencies. Attention has been measured with the Conner's Continuous Performance Task version 2 (CPT-II) task, in order to search for a potential relationship between attentional capacity and the SNR previously obtained. An analysis of variance (ANOVA) shows the best SNR with the middle frequency, followed by the low, and finally the high one. White gives as good an SNR as red at 12 Hz and so does green at 5 Hz, with no differences at 30 Hz. These results suggest that middle frequencies are preferable and that using the red color can be avoided. Correlation analysis also show a correlation between attention and the SNR at low frequency, so suggesting that for the low frequencies, more attentional capacity leads to better results.

15.
Ecol Appl ; 29(5): e01913, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31144784

RESUMO

Marine resources stewardships are progressively becoming more receptive to an effective incorporation of both ecosystem and environmental complexities into the analytical frameworks of fisheries assessment. Understanding and predicting marine fish production for spatially and demographically complex populations in changing environmental conditions is however still a difficult task. Indeed, fisheries assessment is mostly based on deterministic models that lack realistic parameterizations of the intricate biological and physical processes shaping recruitment, a cornerstone in population dynamics. We use here a large metapopulation of a harvested fish, the European hake (Merluccius merluccius), managed across transnational boundaries in the northwestern Mediterranean, to model fish recruitment dynamics in terms of physics-dependent drivers related to dispersal and survival. The connectivity among nearby subpopulations is evaluated by simulating multi-annual Lagrangian indices of larval retention, imports, and self-recruitment. Along with a proxy of the regional hydroclimate influencing early life stages survival, we then statistically determine the relative contribution of dispersal and hydroclimate for recruitment across contiguous management units. We show that inter-annual variability of recruitment is well reproduced by hydroclimatic influences and synthetic connectivity estimates. Self-recruitment (i.e., the ratio of retained locally produced larvae to the total number of incoming larvae) is the most powerful metric as it integrates the roles of retained local recruits and immigrants from surrounding subpopulations and is able to capture circulation patterns affecting recruitment at the scale of management units. We also reveal that the climatic impact on recruitment is spatially structured at regional scale due to contrasting biophysical processes not related to dispersal. Self-recruitment calculated for each management unit explains between 19% and 32.9% of the variance of recruitment variability, that is much larger than the one explained by spawning stock biomass alone, supporting an increase of consideration of connectivity processes into stocks assessment. By acknowledging the structural and ecological complexity of marine populations, this study provides the scientific basis to link spatial management and temporal assessment within large marine metapopulations. Our results suggest that fisheries management could be improved by combining information of physical oceanography (from observing systems and operational models), opening new opportunities such as the development of short-term projections and dynamic spatial management.


Assuntos
Ecossistema , Peixes , Animais , Pesqueiros , Larva , Oceanos e Mares , Dinâmica Populacional
16.
Chaos ; 29(1): 013115, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30709136

RESUMO

In an incompressible flow, fluid density remains invariant along fluid element trajectories. This implies that the spatial distribution of non-interacting noninertial particles in such flows cannot develop density inhomogeneities beyond those that are already introduced in the initial condition. However, in certain practical situations, density is measured or accumulated on (hyper-) surfaces of dimensionality lower than the full dimensionality of the flow in which the particles move. An example is the observation of particle distributions sedimented on the floor of the ocean. In such cases, even if the initial distribution of noninertial particles is uniform but its support is finite, advection in an incompressible flow will give rise to inhomogeneities in the observed density. In this paper, we analytically derive, in the framework of an initially homogeneous particle sheet sedimenting toward a bottom surface, the relationship between the geometry of the flow and the emerging distribution. From a physical point of view, we identify the two processes that generate inhomogeneities to be the stretching within the sheet and the projection of the deformed sheet onto the target surface. We point out that an extreme form of inhomogeneity, caustics, can develop for sheets. We exemplify our geometrical results with simulations of particle advection in a simple kinematic flow, study the dependence on various parameters involved, and illustrate that the basic mechanisms work similarly if the initial (homogeneous) distribution occupies a more general region of finite extension rather than a sheet.

17.
Sensors (Basel) ; 19(20)2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31623093

RESUMO

In this paper, an application for the management, supervision and failure forecast of a ship's energy storage system is developed through a National Marine Electronics Association (NMEA) 2000 smart sensor network. Here, the NMEA 2000 network sensor devices for the measurement and supervision of the parameters inherent to energy storage and energy supply are reviewed. The importance of energy storage systems in ships, the causes and models of battery aging, types of failures, and predictive diagnosis techniques for valve-regulated lead-acid (VRLA) batteries used for assisted and safe navigation are discussed. In ships, battery banks are installed in chambers that normally do not have temperature regulation and therefore are significantly conditioned by the outside temperature. A specific method based on the analysis of the time-series data of random and seasonal factors is proposed for the comparative trend analyses of both the battery internal temperature and the battery installation chamber temperature. The objective is to apply predictive fault diagnosis to detect any undesirable increase in battery temperature using prior indicators of heat dissipation process failure-to avoid the development of the most frequent and dangerous failure modes of VRLA batteries such as dry out and thermal runaway. It is concluded that these failure modes can be conveniently diagnosed by easily recognized patterns, obtained by performing comparative trend analyses to the variables measured onboard by NMEA sensors.

18.
Sensors (Basel) ; 19(3)2019 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-30682842

RESUMO

This contribution proposes an implementation for next generation smart homes, where heterogeneous data, coming from multiple sensors (medical, wellbeing, energy, contextual, etc.) and house equipment (smart fridge, smart TV, etc.), need to be managed, secured and visualized. As a first step, it focuses only on energy and health data. However, it aims to lay the foundations to manage any type of information towards the development of smart interactions with the house, which might include artificial intelligence and machine learning. These data are securely collected using a central Web of Things gateway, located inside the smart home. For the e-health part, a set of possible use-cases is provided, along with the current progress of the implantation. In this regard, the main idea is to link the next generation smart homes with external medical entities in order to provide, first, quick intervention in the event of an abnormality being detected, and to be able to provide basic medical services such as remote consultations with a doctor for a particular health issue. This vision can be very promising, particularly in rural areas, where access to medical services is difficult. As for the energy part, the aim is to collect users' energy consumption inside the smart home, which can be supplied from different sources (heat, water, gas, or electricity), and to enable the use of advanced algorithms to predict and manage local energy consumption and production (if any). This approach combines data collected from smart meters, operational information of the smart energy devices (the status of smart plugs), user's requests and external network signals such as energy prices. By using a home energy management system that accepts such input parameters, the operation of in-home devices and appliances can be optimally controlled according to different objectives (e.g., minimizing energy costs and maximizing user's comfort level).


Assuntos
Algoritmos , Inteligência Artificial , Atenção à Saúde , Humanos
19.
BMC Genomics ; 19(1): 818, 2018 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-30428854

RESUMO

BACKGROUND: Solea senegalensis (Kaup, 1858) is a commercially important flatfish species, belonging to the Pleuronectiformes order. The taxonomy of this group has long been controversial, and the karyotype of the order presents a high degree of variability in diploid number, derived from chromosomal rearrangements such as Robertsonian fusions. Previously it has been proposed that the large metacentric chromosome of S. senegalensis arises from this kind of chromosome rearrangement and that this is a proto-sex chromosome. RESULTS: In this work, the Robertsonian origin of the large metacentric chromosome of S. senegalensis has been tested by the Zoo-FISH technique applied to two species of the Soleidae family (Dicologlossa cuneata and Dagetichthys lusitanica), and by comparative genome analysis with Cynoglossus semilaevis. From the karyotypic analysis we were able to determine a chromosome complement comprising 2n = 50 (FN = 54) in D. cuneata and 2n = 42 (FN = 50) in D. lusitanica. The large metacentric painting probe gave consistent signals in four acrocentric chromosomes of the two Soleidae species; and the genome analysis proved a common origin with four chromosome pairs of C. semilaevis. As a result of the genomic analysis, up to 61 genes were annotated within the thirteen Bacterial Artificial Chromosome clones analysed. CONCLUSIONS: These results confirm that the large metacentric chromosome of S. senegalensis originated from a Robertsonian fusion and provide new data about the chromosome evolution of S. senegalensis in particular, and of Pleuronectiformes in general.


Assuntos
Linguados/genética , Fusão Gênica , Genômica/métodos , Hibridização in Situ Fluorescente/métodos , Translocação Genética , Animais , Mapeamento Cromossômico , Cariotipagem
20.
Pediatr Diabetes ; 19(1): 45-52, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-28493411

RESUMO

BACKGROUND: The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors. MATERIALS AND METHODS: Population-based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9.99 years old. Anthropometric measurements, blood pressure, and fasting blood samples were obtained, including fasting glucose, triglycerides, High Density Lipoprotein (HDL)-cholesterol, and insulin. In addition, QUICKI and HOMA indices were calculated. Generalised additive models for location, scale and shape (GAMLSS) was used to calculate centiles curves and multivariate logistic regression analysis to assess factors associated with IR. RESULTS: A total of 654 subjects were included. Mean values obtained for insulinaemia, HOMA index, and QUICKI were 3.74 µIU/mL, 0.73, and 0.44, respectively, in the overall population and 3.32 µIU/mL, 0.64 and 0.46, respectively, in normal weight subjects. The main factor associated with IR was abdominal obesity (odds ratio [OR] 3.38 [95% CI 1.44-7.94] in the subgroup aged 2.00-5.99 years and OR 9.14 [3.42-24.41] for those aged 6.00-9.99 years). An increased risk of hyperglycaemia (P = 0.043), hypertriglyceridaemia (P < .001), and HDL < p10 (P = 0.021) was described among children aged 2.00 to 5.99 years with IR, and among those aged 6.00 to 9.99 years, IR was associated with an increased risk of hypertriglyceridaemia (P < .001). CONCLUSION: Abdominal obesity was the main factor associated with IR. Metabolic changes associated with IR seem to be present from early stages of life, which highlights the importance of the prevention, early diagnosis and treatment of obesity.


Assuntos
Resistência à Insulina , Insulina/sangue , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Valores de Referência , Fatores de Risco
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