Detalhe da pesquisa
1.
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Bioorg Med Chem Lett
; 50: 128352, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481987
2.
Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 40: 116163, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932711
3.
Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.
Bioorg Med Chem Lett
; 28(21): 3419-3424, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290988
4.
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg Med Chem Lett
; 28(17): 2939-2944, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30122225
5.
Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors.
Bioorg Med Chem Lett
; 28(20): 3307-3311, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30243592
6.
Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol Pharmacol
; 91(3): 208-219, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062735
7.
Corrigendum to "Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors" [Bioorgan. Med. Chem. Lett. 50 (2021) 128352].
Bioorg Med Chem Lett
; 67: 128758, 2022 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484006
8.
Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.
J Biol Chem
; 286(17): 15298-307, 2011 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383008
9.
SAD phasing using iodide ions in a high-throughput structural genomics environment.
J Struct Funct Genomics
; 12(2): 83-95, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21359836
10.
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.
BMC Struct Biol
; 11: 39, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21995815
11.
Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 9): 1051-4, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904049
12.
Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 9): 1055-9, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904050
13.
BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative ß-lactamase-like protein' from Brucella melitensis.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 9): 1106-12, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904058
14.
Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.
ChemMedChem
; 16(24): 3653-3662, 2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582626
15.
Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 5): 558-67, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20445231
16.
Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor.
ACS Med Chem Lett
; 11(6): 1324-1329, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551019
17.
Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.
ChemMedChem
; 15(11): 955-960, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32181984
18.
Structures of Abeta-related peptide--monoclonal antibody complexes.
Biochemistry
; 48(23): 5210-7, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19385664
19.
A preliminary neutron crystallographic study of proteinase K at pD 6.5.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 65(Pt 2): 184-7, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19194016
20.
Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
Struct Dyn
; 6(5): 054702, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31649965