Hydrogen Solubility in Confined Water.

Confined water has demonstrated distinct structural and dynamic properties compared to bulk water. Although many studies have explored the water structure within simple geometries using materials such as carbon and silica, studies on gas solubility in confined water and the underlying physics of water structure-solubility remain limited. Recent research has illuminated the concept of "oversolubility", wherein gases display increased solubility within liquids confined in small pores compared to their bulk form. This study focuses on zeolites, naturally abundant materials with versatile applications, to study the hydrogen solubility within confined water through careful experimentation. Our findings underscore the relationship between the pore dimension and gas solubility enhancement within confined water. Hydrogen solubility is closely associated with the rearrangement of water molecules within the porous framework of the zeolite. Our research shows that a 2 nm pore size results in the greatest increase in hydrogen solubility in the water trapped inside the zeolite framework. The double donor-double acceptor (DDAA) bonds play a critical role in hydrogen solubility. Our research provides fundamental insight into the role of the molecular bonding type on hydrogen solubility in water, paving the way for potential applications in hydrogen storage and utilization.

Gender, Bladder Cancer Healthcare and Burden of COVID-19.

Bladder cancer as one of the main comorbid diseases might be more susceptible to develop COVID-19 infection with a higher mortality risk during the COVID-19 pandemic. The European Association of Urology (EAU) recommended a comprehensive panel for bladder cancer diagnosis and treatment during this global health problem. The urgent need for treatments of COVID-19 during the pandemic has persuaded researchers to evaluate the different medications, which may lead to drug shortages. Therefore, in this review paper, we have focused on the least recommendations of EAU about bladder cancer during of COVID-19 pandemic to provide a comprehensive panel for high-risk patients.

Competencies for dental public health specialists: A thematic analysis.

INTRODUCTION: Competency frameworks have been used to accurately guide the training and assessment of professionals. Dental Public Health professionals require a variety of skills beyond clinical aspects to meet ongoing social, economic, epidemiologic, technological, etc. developments. The purpose of this study was to develop a primary competency framework for dental public health (DPH) professionals by reviewing existing documents that can be modified by authorities based on their needs. MATERIALS AND METHODS: To identify DPH competencies, first a literature review of current postgraduate DPH competencies was conducted in PubMed, Scopus, Google Scholar, and Google from May to June 2021. All English language documents addressing DPH competencies were included and transferred to MAXQDA software. Next, DPH competency domains were extracted and defined, using Clarke and Braun's six-step qualitative thematic analysis method. RESULTS: In total, 206 English documents were retrieved. After exclusion of 201 documents due to being duplicate or not related in screening stages, five full-text English documents describing competencies of DPH specialists from the United Kingdom, the United States, Australia and New Zealand, Canada, and Ireland were reviewed. Thematic analysis led to the provision of a framework consisting of all mentioned competencies in the reviewed documents including nine domains in education, research, management, policy, communication, leadership, professionalism, oral health status, and oral health services. CONCLUSION: The proposed primary framework covers all competency domains and, as a comprehensive tool, can be used as a guide by local, national, and international authorities to develop their own frameworks for training and evaluating the DPH workforce.

Chlorella vulgaris ameliorates testicular toxicity induced by carbon tetrachloride in male rats via modulating oxidative stress.

This study was aimed to evaluate the protective effects of Chlorella Vulgaris (CVE) (50 and 100 mg/kg doses) on sperm DNA fragmentation, testis oxidative stress in Carbon tetrachloride (CCL4)-exposed rats. Thirty healthy male Wistar rats were divided into five groups (n = 6): Control; CCl4; CVE; CCl4 + CVE50; CCl4 + CVE100. At the end of the experiment, the testicular oxidative stress parameters were estimated. The Chromomycin A3 (CMA3) and Acridine orange (AO) staining were performed to examine the sperm DNA fragmentation status. CCl4 treatment showed a significant decrease in antioxidant markers and sperm count, viability, normal morphology and motility as well as significantly increased the testicular oxidative stress markers, and the percentage of CMA3 and AO positive sperms in normal rats (p < 0.05). While CVE supplementation has revealed a significant decrease in the percentage of CMA3 and AO positive sperms as well as testicular oxidative stress markers and considerably improved the testis antioxidant status (p < 0.05). CVE has also increased the number of sperms with forwarding movement, normal morphology and viability (p < 0.05). Taken together, our analyses suggest that CVE may play a critical role in attenuating the CCl4-induced oxidative stress in the testis, thereby protecting the sperm membrane and DNA against oxidative damage.

The Overexpression of Sonic Hedgehog Associates with Collateral Development and Amelioration of Oxidative Stress in Stroke Patients.

PURPOSE: Sonic hedgehog (SHH) signaling pathway in oxidative stress condition has been acknowledged as a key trigger for angiogenesis and collateral vessel growth in the ischemic brain, and it exerts a protective effect on neuronal cells during oxidative stress. METHODS: A total of sixty patients (n = 30 good collateral profile and n = 30 poor collateral profile) diagnosed with acute cerebral ischemia were enrolled in this study. qRT-PCR was performed to analyze the expression levels of SHH, Gli1, and superoxide dismutase (SOD), genes. Also, the serum levels of oxidative stress markers were determined in experimental groups. RESULTS: The expression levels of SHH and Gli1 genes were significantly (p < 0.05) higher in stroke patients with good collateral circulation compared with those with poor collateral circulation, while SOD gene expression was similar between two groups (p > 0.05). A significantly positive correlation was found between the gene expression of SHH and Gli1 (r = 0.604, p < 0.001), SOD and Gli1 (r = 0.372, p < 0.003) genes. Our findings showed that the serum level of total antioxidant capacity (TAC) and Glutathione (GSH) and SOD enzyme activity was significantly (p < 0.05) increased, while serum total oxidant status (TOS) and malondialdehyde (MDA) levels were significantly (p < 0.05) decreased in patients with good collateral circulation as compared with those with poor collateral circulation. CONCLUSION: Our observations shed light on the association of the SHH/Gli1 signaling pathway with cerebral collateral vessel development following ischemia. Oxidative stress in stroke patients with poor collateral circulation may result in the overexpression of SHH/Gli1 signaling pathway which possibly contribute to oxidative stress attenuation, as well as modulate angiogenesis and collateral vessels development.

Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients.

Cells translate the mechanosensing of extracellular matrix component dysregulation and stiffness into the signal transduction including Osteopontin (OPN) through the Hippo pathway. But how extracellular matrix (ECM) component dysregulation and stiffness are ultimately linked to transitional cell carcinoma (TCC) development remains poorly understood. This study was aimed to evaluate the possible links between ECM component alteration after cancer surgery and OPN and Yes-associated protein (YAP) expression in TCC and adjacent tissues. In this study, we used 50 TCC (25 newly diagnosed and 25 recurrent) and 50 adjacent tissues to determine the tissue stiffness using atomic force microscopy. The mRNA expression of SPP1, Indian hedgehog (IHH), and YAP was also determined using qRT-PCR. Western blotting and ELISA were performed to assess the tissue and serum levels of OPN, respectively. To assess the glycoproteins and elastic fibers content, Periodic Acid Schiff, and Verhoeff-Van Gieson Staining were performed, respectively. Matrix stiffness was markedly higher in TCCs than adjacent tissues (p < 0.05). Gene expression analysis showed that YAP, SPP1, and IHH genes were upregulated in TCC tissues (p < 0.05). Additionally, the OPN protein overexpression was observed in the tissue and the serum of TCC patients (p < 0.05). We also found that glycoproteins, elastic fibers content of recurrent TCC tissues was remarkably higher as compared to adjacent tissues (p < 0.05). Our results suggest that glycoproteins and elastic fibers content modulation and ECM stiffness may upregulates the expression of YAP, SPP1 and IHH genes, and possibly contribute to the TCC development and relapse.

Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.

Reactive Oxygen Species Modulator 1 (ROMO1) plays a pivotal role in the regulation of mitochondrial structure integrity, and the production of reactive oxygen species (ROS). Increased ROMO1 expression was reported in various cancer cell lines; however, the possible association between ROMO1 expression and bladder cancer was not well studied. The present study aimed to investigate the rate of ROMO1 expression and the correlation of oxidative stress with the development of bladder cancer. In this study, a total of 35 cancerous and healthy adjacent tissues were examined using quantitative real-time polymerase chain reaction (qRT-PCR) to analyze the gene expression of ROMO1. Also, we evaluated the serum level of ROMO1 and Total Antioxidant Capacity (TAC), as well as Total Oxidant Status (TOS) in patients with bladder cancer along with age- and sex-matched healthy individuals. The ROMO1 gene was significantly higher in cancerous tissues than that of adjacent healthy tissues. Also, the serum levels of ROMO1, TAC, TOS, and Oxidative Stress Index (OSI) were increased in patients with bladder cancer compared with healthy subjects. It can be concluded that the overexpression of the ROMO1 gene is associated with advanced grades of bladder cancer as well as an increase in oxidative stress conditions. Our findings also suggest that the serum level of ROMO1 might be a promising tumor marker for bladder cancer.

Ultrahigh Evaporative Heat Fluxes in Nanoconfined Geometries.

Advancement in high-performance photonics/electronics devices has boosted generated thermal energy, making thermal management a bottleneck for accelerated innovation in these disciplines. Although various methods have been used to tackle the thermal management problem, evaporation with nanometer fluid thickness is one of the most promising approaches for future technological demands. Here, we studied thin-film evaporation in nanochannels under absolute negative pressure in both transient and steady-state conditions. We demonstrated that thin-film evaporation in nanochannels can be a bubble-free process even at temperatures higher than boiling temperature, providing high reliability in thermal management systems. To achieve this bubble-free characteristic, the dimension of nanochannels should be smaller than the critical nucleolus dimension. In transient evaporative conditions, there is a plateau in the velocity of liquid in the nanochannels, which limits the evaporative heat flux. This limit is imposed by liquid viscous dissipation in the moving evaporative meniscus. In contrast, in steady-state condition, unprecedented average interfacial heat flux of 11 ± 2 kW cm-2 is achieved in the nanochannels, which corresponds to liquid velocity of 0.204 m s-1. This ultrahigh heat flux is demonstrated for a long period of time. The vapor outward transport from the interface is both advective and diffusion controlled. The momentum transport of liquid to the interface is the limiting physics of evaporation at steady state. The developed concept and platform provide a rational route to design thermal management technologies for high-performance electronic systems.

Stress-localized durable anti-biofouling surfaces.

Growing demands for bio-friendly antifouling surfaces have stimulated the development of new and ever-improving material paradigms. Despite notable progress in bio-friendly coatings, the biofouling problem remains a critical challenge. In addition to biofouling characteristics, mechanically stressed surfaces such as ship hulls, piping systems, and heat exchangers require long-term durability in marine environments. Here, we introduce a new generation of anti-biofouling coatings with superior characteristics and high mechanical, chemical and environmental durability. In these surfaces, we have implemented the new physics of stress localization to minimize the adhesion of bio-species on the coatings. This polymeric material contains dispersed organogels in a high shear modulus matrix. Interfacial cavitation induced at the interface of bio-species and organogel particles leads to stress localization and detachment of bio-species from these surfaces with minimal shear stress. In a comprehensive study, the performance of these surfaces is assessed for both soft and hard biofouling including Ulva, bacteria, diatoms, barnacles and mussels, and is compared with that of state-of-the-art surfaces. These surfaces show Ulva accumulation of less than 1%, minimal bacterial biofilm growth, diatom attachment of 2%, barnacle adhesion of 0.02 MPa and mussel adhesion of 7.5 N. These surfaces promise a new physics-based route to address the biofouling problem and avoid adverse effects of biofouling on the environment and relevant technologies.

Evaporation Mass Flux: A Predictive Model and Experiments.

Evaporation is a fundamental and core phenomenon in a broad range of disciplines including power generation and refrigeration systems, desalination, electronic/photonic cooling, aviation systems, and even biosciences. Despite its importance, the current theories on evaporation suffer from fitting coefficients with reported values varying in a few orders of magnitude. Lack of a sound model impedes simulation and prediction of characteristics of many systems in these disciplines. Here, we studied evaporation at a planar liquid-vapor interface through a custom-designed, controlled, and automated experimental setup. This experimental setup provides the ability to accurately probe thermodynamic properties in vapor, liquid, and close to the liquid-vapor interface. Through analysis of these thermodynamic properties in a wide range of evaporation mass fluxes, we cast a predictive model of evaporation based on nonequilibrium thermodynamics with no fitting parameters. In this model, only the interfacial temperatures of liquid and vapor phases along with the vapor pressure are needed to predict evaporation mass flux. The model was validated by the reported study of an independent research group. The developed model provides a foundation for all liquid-vapor phase change studies including energy, water, and biological systems.

Decoupled Hierarchical Structures for Suppression of Leidenfrost Phenomenon.

Thermal management of high temperature systems through cooling droplets is limited by the existence of the Leidenfrost point (LFP), at which the formation of a continuous vapor film between a hot solid and a cooling droplet diminishes the heat transfer rate. This limit results in a bottleneck for the advancement of the wide spectrum of systems including high-temperature power generation, electronics/photonics, reactors, and spacecraft. Despite a long time effort on development of surfaces for suppression of this phenomenon, this limit has only shifted to higher temperatures, but still exists. Here, we report a new multiscale decoupled hierarchical structure that suppress the Leidenfrost state and provide efficient heat dissipation at high temperatures. The architecture of these structures is composed of a nanomembrane assembled on top of a deep micropillar structure. This architecture allows to independently tune the involved forces and to suppress LFP. Once a cooling droplet contacts these surfaces, by rerouting the path of vapor flow, the cooling droplet remains attached to the hot solid substrates even at high temperatures (up to 570 °C) for heat dissipation with no existence of Leidenfrost phenomenon. These new surfaces offer unprecedented heat dissipation capacity at high temperatures (2 orders of magnitude higher than the other state-of-the-art surfaces). We envision that these surfaces open a new avenue in thermal management of high-temperature systems through spray cooling.

Charging-free electrochemical system for harvesting low-grade thermal energy.

Efficient and low-cost systems are needed to harvest the tremendous amount of energy stored in low-grade heat sources (<100 °C). Thermally regenerative electrochemical cycle (TREC) is an attractive approach which uses the temperature dependence of electrochemical cell voltage to construct a thermodynamic cycle for direct heat-to-electricity conversion. By varying temperature, an electrochemical cell is charged at a lower voltage than discharge, converting thermal energy to electricity. Most TREC systems still require external electricity for charging, which complicates system designs and limits their applications. Here, we demonstrate a charging-free TREC consisting of an inexpensive soluble Fe(CN)6(3-/4-) redox pair and solid Prussian blue particles as active materials for the two electrodes. In this system, the spontaneous directions of the full-cell reaction are opposite at low and high temperatures. Therefore, the two electrochemical processes at both low and high temperatures in a cycle are discharge. Heat-to-electricity conversion efficiency of 2.0% can be reached for the TREC operating between 20 and 60 °C. This charging-free TREC system may have potential application for harvesting low-grade heat from the environment, especially in remote areas.

Offspring sex ratio of Iranian dentists.

OBJECTIVE: To assess the impact of occupational factors on the sex ratio of dentists' children. METHODS: A randomly selected 501 Iranian dentists participated in a telephone interview. The participants were contacted by their mobile number to answer questions about demographic variables (gender, age, marriage status), practice-related variables (year of graduation as general or specialist dentist, years of clinical work, working hours, average number of radiographs taken in a day, and spouse's job), and questions about their children (number, gender and date of birth of each child). Kruskal-Wallis and Chi-square tests served for statistical evaluation. RESULTS: Of all participating dentists, 71 % were men, about two-thirds were 35- to 50-year olds, and 89 % were married. In total, the dentists had 768 children; about 21 % had no child. Of all the children, 54 % were boys (overall sex ratio = 1.17). The offspring sex ratio was 1.13 among male dentists, 1.50 for female dentists, and 1.44 when both parents were dentists. Higher percentages of boys were prevalent among female dentists, younger dentists, and general dental practitioners (p < 0.008). CONCLUSION: Demographic and practice-related factors showed some impact on proportions of both sexes of dentists' children in this study. However, the result needs evaluation in further studies.

Membrane-free battery for harvesting low-grade thermal energy.

Efficient and low-cost systems are desired to harvest the tremendous amount of energy stored in low-grade heat sources (<100 °C). An attractive approach is the thermally regenerative electrochemical cycle (TREC), which uses the dependence of electrode potential on temperature to construct a thermodynamic cycle for direct heat-to-electricity conversion. By varying the temperature, an electrochemical cell is charged at a lower voltage than discharged; thus, thermal energy is converted to electricity. Recently, a Prussian blue analog-based system with high efficiency has been demonstrated. However, the use of an ion-selective membrane in this system raises concerns about the overall cost, which is crucial for waste heat harvesting. Here, we report on a new membrane-free battery with a nickel hexacyanoferrate (NiHCF) cathode and a silver/silver chloride anode. The system has a temperature coefficient of -0.74 mV K(-1). When the battery is discharged at 15 °C and recharged at 55 °C, thermal-to-electricity conversion efficiencies of 2.6% and 3.5% are achieved with assumed heat recuperation of 50% and 70%, respctively. This work opens new opportunities for using membrane-free electrochemical systems to harvest waste heat.

Knowledge of and Attitude Toward Preventive Care Among Iraqi Dentists and Senior Dental Students: A Cross-Sectional Study.

OBJECTIVES: Acquiring knowledge and maintaining a positive mindset are essential for dental care providers to offer optimal dental services. Dental professionals are expected to follow preventive dentistry principles to ensure the best oral health maintenance for their patients, as prevention is a key component of public health initiatives. This study aims to assess the knowledge and attitudes toward preventive dental care among Iraqi dentists and senior dental students. METHODOLOGY: A cross-sectional study, conducted from June to August 2023, involved 876 Iraqi dentists and 587 senior dental students in Baghdad, utilizing a physically paper-based self-administered questionnaire. Participants' level of knowledge was assessed based on a 5-point Likert scale to 12 statements on preventive dental care. Their attitudes were inquired by selecting one option from a 7-point Likert scale on four pairs of bipolar adjectives describing preventive dentistry. Higher scores were considered more accurate knowledge and more positive attitudes. Statistical evaluation included the Chi-square test and regression analysis. RESULTS: In total, data from 841 dentists and 567 students were analyzed (response rate: 96%). Around 90% of dentists (N=745) and students (N=502) acknowledged the impact of sugar, sealant, and water fluoridation on dental caries, but about 80% of dentists (N=662) and students (N=446) undervalued the role of fluoridated toothpaste. Women (OR=1.4, 95% CI: 1.02-2.1) and dentists, within one year of their graduation (OR=1.9, 95% CI: 1.1-3.5), exhibited higher levels of knowledge. More favorable attitudes towards preventive dentistry were associated with a higher level of knowledge among dentists (OR=1.6, 95% CI: 1.2-2.3). Regarding dental students, those from private dental schools showed higher scores of knowledge than their counterparts from public schools (OR=2.1, 95% CI: 1.3-3.4). The majority of participants held the belief that preventive dentistry is beneficial for the community but just about 60% of dentists (N=477) and students (N=300) exhibited a positive attitude toward the economic advantages of preventive dentistry for dentists, as well as the ease of engaging in preventive dental practices. CONCLUSIONS: The dentists and dental students in this study demonstrated satisfactory knowledge and a favorable attitude toward most aspects of preventive dentistry. However, deficiencies were noted in certain areas, such as the application of topical fluoride for preventing dental caries, as well as a substantial proportion of individuals who lacked a positive perspective on the economic benefits of preventive dentistry. Hence, there is a clear need for educational interventions during their undergraduate training and postgraduate continuing education to enhance their knowledge levels and cultivate a more positive attitude towards preventive dentistry.

Association between dental clinical measures and oral health-related quality of life among Iraqi schoolchildren: A cross-sectional study.

OBJECTIVE: The aim of this study was to assess the association between dental clinical measures and oral health-related quality of life (OHRQoL) together with the potential mediating role of sociodemographic factors and oral health behaviours on this association in a group of Iraqi children. METHODS: The target population for this cross-sectional study consisted of 372 primary school children aged 8-10 years in the city of Kut, Iraq, during the year 2022. The participants were selected using a multi-stage random sampling technique. Detailed information about the children was collected through a comprehensive questionnaire that included demographic characteristics, oral health-related behaviors, the Arabic version of the Child Perceptions Questionnaire for 8-10-year-olds (CPQ8-10), and parental knowledge regarding oral health. Additionally, clinical dental evaluations were conducted, which included assessments of decayed, missing, and filled surfaces (DMFS, dmfs) as well as teeth (DMFT, dmft). Simplified oral hygiene index (OHI-S), bleeding on probing (BOP), and the community periodontal index (CPI) were also recorded for each participant using the recommended methodology by the World Health Organization (WHO). The statistical analysis included the Chi-square test, independent t-test, and simple and multiple linear regressions. RESULTS: The mean age of the children was 9.0 (± 0.82) years. About one-third of children reported brushing at least two times per day and consuming a sweet snack once a day. Visiting a dentist during the past year was reported by 21% of children. Oral health behaviours demonstrated a significant association with the total CPQ8-10 scores (p < 0.001). Based on adjusted effects (ß and 95% CI) from the multiple linear regressions, untreated dental caries (dt > 0, DT > 0) had a negative impact on the total CPQ8-10 score (adjusted ß = 2.3 (95% CI: 0.67 to 3.91) and 3.4 (95% CI: 2.14 to 4.56), respectively). Decayed surfaces (DS), and teeth (DT) were associated with the total score of the CPQ8-10 and all its subscales (adjusted ß range = 0.1 (95% C.I.: 0.03 to 0.19)-1.0 (95% CI: 0.72 to 1.26) and 0.2 (95% CI: 0.004 to 0.40)-1.2 (95% CI: 0.91 to 1.67), respectively). There was an association between oral hygiene index and total CPQ8-10 scores (adjusted ß = 1.8 (95% CI: 0.62 to 3.02)), especially the functional limitations and emotional well-being subscales. CONCLUSION: Findings of this study emphasizes the negative impact of dental caries and poor oral hygiene on children's OHRQoL. This association is highlighted more when considering that over two-thirds of these children do not comply with favourable levels of oral health behaviour. Enhancing the level of OHRQoL among these children, therefore, necessitates comprehensive programs for decreasing the volume of unmet oral health needs and improving children's adherence to recommended oral health behaviours.

Regulation of Epithelial-Mesenchymal Transition by Cyrtopodion Scabrum: An in vitro Study against Colorectal Cancer Cells.

BACKGROUND: Natural treatment of cancer has received a lot of attention recently due to its advantages including low cost, and fewer side effects. In this study, we aimed to investigate the antimetastatic properties of Cyrtopodion scabrum, a common home gecko, through Epithelial-Mesenchymal Transition (EMT) process. METHODS: Human colon cancer HCT116 cell line was selected and allocated into the following experimental groups: untreated control, vehicle control (DMSO), Retinoic acid (RA), and two treatment groups including aqueous C.scabrum Whole Extract (CWE) and C.scabrum Cell Extract (CCE) groups. The effects of the two different extracts on the viability, migration, and morphology of HCT116 cells were investigated using MTT, colony formation, and wound healing assay as well as microscopic evaluation. We also investigated the gene expression of E-cad, N-cad, and Snail genes using Real-Time PCR analysis. RESULTS: Our findings revealed that CWE and CCE were toxic to the HCT116 cell line with IC50 values of 590 and 680 µg/mL, respectively. Colony formation and migration ability of cancer cells were also inhibited by the two extracts, and the morphology of the cells were determined as epithelial phenotype. Moreover, the expression of N-cad and Snail were remarkably decreased in CWE and CCE, and RA groups, while E-cad didn't change significantly as compared to the control. CONCLUSION: The results suggest that C. scabrum extract (CsE) may induce its anti-cancer activity through the inhibition of cancer cell growth and the EMT process. CCE, as a valuable natural source, could be also suggested, to be used as an alternative/complementary medicine for the treatment of cancer, in clinical trials.

Molecular Modelling of Resveratrol Derivatives with SIRT1 for the Stimulation of Deacetylase Activity.

BACKGROUND: Resveratrol is a polyphenol that is found in plants and has been proposed to have a potential therapeutic effect through the activation of SIRT1, which is a crucial member of the mammalian NAD+-dependent deacetylases. However, how its activity is enhanced toward specific substrates by resveratrol derivatives has not been studied. This study aimed to evaluate the types of interaction of resveratrol and its derivatives with SIRT1 as the target protein, as well as to find out the best ligand with the strangest interaction with SIRT1. METHODS: In this study, we employed the extensive molecular docking analysis using AutoDock Vina to comparatively evaluate the interactions of resveratrol derivatives (22 molecules from the ZINC database) as ligands with SIRT1 (PDB ID: 5BTR) as a receptor. The ChemDraw and Chem3D tools were used to prepare 3D structures of all ligands and energetically minimize them by the MM2 force field. RESULTS: The molecular docking and visualizations showed that conformational change in resveratrol derivatives significantly influenced the parameter for docking results. Several types of interactions, including conventional hydrogen bonds, carbon-hydrogen bonds, Pi-donor hydrogen bonds, and Pi-Alkyl, were found via docking analysis of resveratrol derivatives and SIRT1 receptors. The possible activation effect of resveratrol 4'-(6-Galloylglucoside) with ZINC ID: ZINC230079516 with higher binding energy score (-46.8608 kJ/mol) to the catalytic domain (CD) of SIRT1 was achieved at the maximum value for SIRT1, as compared to resveratrol and its other derivatives. CONCLUSION: Finally, resveratrol 4'-(6-Galloylglucoside), as a derivative for resveratrol, has stably interacted with the CD of SIRT1 and might be a potential effective activator for SIRT1.

Predictive model of ice adhesion on non-elastomeric materials.

HYPOTHESIS: When ice accumulates on a surface, it can adversely impact functionality and safety of a platform in infrastructure, transportation, and energy sectors. Despite several attempts to model the ice adhesion strength on ice-shedding materials, none have been able to justify variation in the ice adhesion strength measured by various laboratories on a simple bare substrate. This is primarily due to the fact that the effect of underlying substrate of an ice-shedding material has been entirely neglected. EXPERIMENTS: Here, we establish a comprehensive predictive model for ice adhesion using the shear force method on a multi-layered material. The model considers both shear resistance of the material and shear stress transfer to the underlying substrate. We conducted experiments to validate the model predictions on the effect of coating and substrate properties on the ice adhesion. FINDINGS: The model reveals the importance of the underlying substrate of a coating on ice adhesion. Most importantly, the correlation between the ice adhesion and the coating thickness are entirely different for elastomeric and non-elastomeric materials. This model justifies different measured ice adhesion across various laboratories on the same material and elucidates how one could achieve both low ice adhesion and high mechanical durability. Such predictive model and understanding provides a rich platform to guide the future material innovation with minimal adhesion to the ice.

Protective Effect of Curcumin and Nanocurcumin on Sperm Parameters and Oxidant-antioxidants System of Rat Testis in Aluminium Phosphide Subacute Poisoning.

OBJECTIVE: Aluminum phosphide (AlP) as an effective pesticide may contribute to oxidative stress and adversely influence sperm parameters. This study aimed to investigate the protective role of curcumin and nanocurcumin on oxidative damage in the testis of rats with AlP toxicity. METHODS: A total of 42 adult male Wistar rats were equally randomized into the following study groups (n = 7): Control, Control+Curcumin, Control+Nanocurcumin, AlP, AlP+Curcumin, and AlP+Nanocurcumin. The testis tissue was used to investigate the levels of testicular malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), and reduced glutathione (GSH) as well as the Catalase (CAT) and superoxide dismutase (SOD) enzyme activity. Epididymal sperm was used to perform sperm analysis. RESULTS: AlP administration led to a significant increase in MDA, and TOS levels and also markedly decreased the SOD activity and the levels of TAC and GSH in testis tissue (p <0.001). Moreover, the motility and viability of sperms were significantly reduced (p <0.001). Curcumin and Nanocurcumin co-administration with AlP remarkably decreased the MDA and TOS level (p <0.001) and significantly increased the GSH and TAC levels as well as the activity of SOD in AlP intoxicated groups (p<0.001). Our findings demonstrated that Nanocurcumin administration has significantly enhanced the sperm quality in AlP intoxicated rats as compared to the control group (p <0.001). CONCLUSION: According to the results of this study, Curcumin as a potential antioxidant could be an effective attenuative agent against AlP-induced oxidative damage in testis, especially when it is used in encapsulated form, nanocurcumin.