RESUMO
We wanted to test the hypothesis that treatment with amiloride or spironolactone reduced ambulatory (ABP) and central blood pressure (CBP) and that tubular transport via ENaCγ and AQP2 was increased after furosemide treatment. During baseline conditions, there were no differences in ABP, CBP, renal tubular function, or plasma concentrations of vasoactive hormones. After furosemide treatment, an increase in CBP, CH(2)o, FE(Na), FE(K), u-AQP2/min, u-ENaCγ/min, PRC, p-Ang II, and p-Aldo was observed. The increases in water and sodium absorption via AQP2 and ENaC after furosemide treatment most likely are compensatory phenomena to antagonize water and sodium depletion.
Assuntos
Amilorida/farmacologia , Monitorização Ambulatorial da Pressão Arterial , Pressão Sanguínea/efeitos dos fármacos , Diuréticos/farmacologia , Taxa de Filtração Glomerular/efeitos dos fármacos , Túbulos Renais/efeitos dos fármacos , Análise de Onda de Pulso , Espironolactona/farmacologia , Adolescente , Adulto , Algoritmos , Aquaporina 2/urina , Biomarcadores/urina , Monitorização Ambulatorial da Pressão Arterial/métodos , Estudos Cross-Over , Método Duplo-Cego , Canais Epiteliais de Sódio/efeitos dos fármacos , Feminino , Humanos , Túbulos Renais/fisiopatologia , Masculino , Sistema Renina-Angiotensina/efeitos dos fármacosRESUMO
A lung abscess is a necrotising infection leading to loss of healthy lung tissue. It develops over several weeks, and the typical presentation includes cough, fever, and general deterioration. The clinical work-up includes contrast-enhanced CT-scans, and frequently flexible bronchoscopy with broncho-alveolar lavage as described in this review. The infection commonly represents aspiration of oral bacterial flora, including anaerobic microbes. Penicillin resistance is common. A lung abscess generally requires long-term, tailored antibiotic treatment. The patient should consult a dentist to identify possible dental foci.
Assuntos
Abscesso Pulmonar , Antibacterianos/uso terapêutico , Bactérias , Broncoscopia , Humanos , Pulmão , Abscesso Pulmonar/diagnóstico por imagem , Abscesso Pulmonar/tratamento farmacológicoRESUMO
We herein report a rare case that describes and visualizes nocardiosis in a patient with diabetes. The patient presented with recurring fever, gout, leg pain, frailty and muscular pain through nine months, before a core needle biopsi, from an abscess in the abdominal musculature, revealed Nocardia Paucivorans. A PET-CT-scan showed multiple muscular FDG-positive sites. Furthermore, he experienced serious side effects to Sulfametoxazole and Trimethoprim, the antibiotic of choice for this type of infection. He was then switched to Moxifloxacin and Ampicillin. Nocardia often presents as opportunistic infections, typically in patients with severe immunodeficiencies, such as HIV, use of high-dose corticosteroids, hematologic malignancies or immunosuppression following organ transplantation. This case illustrates how a patient with only relative immunodeficiency gets rare nocardiosis. Our sparse knowledge on clinical presentation is based on case-reports and treatment is empirical. Hence, a better understanding of the clinical presentation and treatment is important. Especially given the prospect, that the health care system faces a greater load of patients with diabetes and other immunodeficiencies in the future.
RESUMO
The decision to limit or discontinue treatment is a difficult issue, which all physicians will face. Timely communication with information on treatment possibilities and limitations, respectful listening to patients' and informal caregivers' wishes and early palliation is recommended in a stable phase. In some situations, it is better to stop life-prolonging treatment and optimise quality of life in patients with benign pulmonary diseases. Decision on treatment limitations or discontinuation is best taken at a conference and should be based on the patient's wishes, the disease stage and progression and potential reversible components.
Assuntos
Pneumopatias/terapia , Cuidados Paliativos , Suspensão de Tratamento , Planejamento Antecipado de Cuidados , Cuidadores , Humanos , Fibrose Pulmonar Idiopática/terapia , Doenças Pulmonares Intersticiais/terapia , Preferência do Paciente , Relações Médico-Paciente , Doença Pulmonar Obstrutiva Crônica/terapia , Qualidade de Vida , Assistência TerminalRESUMO
BACKGROUND: The mechanisms involved in development and maintenance of hypertension in obstructive sleep apnea (OSA) are not clarified. We hypothesize that patients with OSA have an abnormal nocturnal level of some vasoactive hormones during the night. METHODS: We studied 32 patients with OSA and 19 healthy control subjects during The night-time with serial determinations of endothelin-1 (ENDO-1), angiotensin II (Ang II), renin (PRC), aldosterone (ALDO) in plasma, and blood pressure (BP), and oxygen saturation. RESULTS: Patients with OSA had a higher plasma level of ENDO than healthy controls and the mean nocturnal level of ENDO correlated significantly to the apnea-hypopnea index (AHI) as a measure of the severity of OSA. This correlation remained statistically significant after analysis in a general linear model with correction for confounders. Patients with OSA also had a significantly higher BP than healthy controls and the ambulatory BP correlated positively to the AHI in patients with OSA. No significant differences were measured in Ang II, PRC, and ALDO between the two groups. The correlation between AHI and ENDO supports OSA as a stimulus of endothelin release or increased endothelin levels contributing to the severity of OSA. CONCLUSIONS: Endothelin seems to be a pathogenic factor in generating hypertension in OSA.
Assuntos
Pressão Sanguínea/fisiologia , Endotelina-1/sangue , Hipertensão/fisiopatologia , Oxigênio/sangue , Apneia Obstrutiva do Sono/sangue , Adulto , Aldosterona/sangue , Angiotensina II/sangue , Anti-Hipertensivos/uso terapêutico , Monitorização Ambulatorial da Pressão Arterial , Estudos de Casos e Controles , Feminino , Frequência Cardíaca/fisiologia , Humanos , Hipertensão/tratamento farmacológico , Hipertensão/etiologia , Masculino , Pessoa de Meia-Idade , Renina/sangue , Apneia Obstrutiva do Sono/complicaçõesRESUMO
Leiomyomas arise from the smooth muscle cells of the lung and account for less than 2% of all benign tumours of the lung. Symptomatology is based on the degree of bronchial obstruction. Endobronchial leiomyomas often present with obstructive pneumonia and atelectasis. We present a case report of a 17-year-old woman who had pneumonia of the right lower lobe. The anamnesis revealed three previous hospitalizations over the last one and a half years due to pneumonia of the right lung. A diagnosis of primary endobronchial leiomyoma was made on the basis of histopathology and immunohistochemistry obtained during bronchoscopy.
Assuntos
Neoplasias Brônquicas/complicações , Leiomioma/complicações , Pneumonia/etiologia , Adolescente , Neoplasias Brônquicas/diagnóstico , Neoplasias Brônquicas/patologia , Neoplasias Brônquicas/cirurgia , Feminino , Humanos , Leiomioma/diagnóstico , Leiomioma/patologia , Leiomioma/cirurgia , RecidivaRESUMO
Obstructive Sleep Apnoea (OSA) is associated with repeated episodes of hypoxia, arousals and considerable haemodynamic changes during sleep. There is an established causal link between OSA and cardiovascular disease, in particular hypertension. The mechanisms responsible include altered autonomic activity, neuroendocrine vascular control, metabolic derangement, and vascular endothelial dysfunction. OSA is a treatable condition frequently occurring in association with other cardiovascular risk factors that should be considered in the context of hypertension.