Detalhe da pesquisa
1.
Facile discovery of surrogate cytokine agonists.
Cell
; 185(8): 1414-1430.e19, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35325595
2.
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell
; 184(4): 983-999.e24, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33606986
3.
An engineered IL-2 partial agonist promotes CD8+ T cell stemness.
Nature
; 597(7877): 544-548, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34526724
4.
Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc Natl Acad Sci U S A
; 120(11): e2218238120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893265
5.
A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.
Immunity
; 43(2): 227-39, 2015 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26231119
6.
Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch.
Proc Natl Acad Sci U S A
; 117(13): 7183-7192, 2020 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184322
7.
Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.
Proc Natl Acad Sci U S A
; 115(31): E7369-E7378, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30021852
8.
The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.
J Immunol
; 196(11): 4713-22, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27183595
9.
Emerging principles of cytokine pharmacology and therapeutics.
Nat Rev Drug Discov
; 22(1): 21-37, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36131080
10.
Structural basis of Janus kinase trans-activation.
Cell Rep
; 42(3): 112201, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36867534
11.
Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Science
; 381(6656): eadh1720, 2023 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37499032
12.
IL-2-induced Stat3 Signaling is Critical for Effector Treg Cell Programming.
bioRxiv
; 2023 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37808649
13.
Structure of the IL-27 quaternary receptor signaling complex.
Elife
; 112022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35579417
14.
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Science
; 376(6589): 163-169, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35271300
15.
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
Elife
; 102021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34003116
16.
Accurate prediction of protein structures and interactions using a three-track neural network.
Science
; 373(6557): 871-876, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34282049
17.
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
Elife
; 92020 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32773038
18.
Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.
Cell Rep
; 22(5): 1263-1275, 2018 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29386113
19.
A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.
PLoS One
; 10(7): e0132333, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147390
20.
Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.
PLoS One
; 11(3): e0150876, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26930656