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1.
J Med Internet Res ; 25: e43518, 2023 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-37195755

RESUMO

BACKGROUND: Occupancy rates within skilled nursing facilities (SNFs) in the United States have reached a record low. Understanding drivers of occupancy, including admission decisions, is critical for assessing the recovery of the long-term care sector as a whole. We provide the first comprehensive analysis of financial, clinical, and operational factors that impact whether a patient referral to an SNF is accepted or denied, using a large health informatics database. OBJECTIVE: Our key objectives were to describe the distribution of referrals sent to SNFs in terms of key referral- and facility-level features; analyze key financial, clinical, and operational variables and their relationship to admission decisions; and identify the key potential reasons behind referral decisions in the context of learning health systems. METHODS: We extracted and cleaned referral data from 627 SNFs from January 2020 to March 2022, including information on SNF daily operations (occupancy and nursing hours), referral-level factors (insurance type and primary diagnosis), and facility-level factors (overall 5-star rating and urban versus rural status). We computed descriptive statistics and applied regression modeling to identify and describe the relationships between these factors and referral decisions, considering them individually and controlling for other factors to understand their impact on the decision-making process. RESULTS: When analyzing daily operation values, no significant relationship between SNF occupancy or nursing hours and referral acceptance was observed (P>.05). By analyzing referral-level factors, we found that the primary diagnosis category and insurance type of the patient were significantly related to referral acceptance (P<.05). Referrals with primary diagnoses within the category "Diseases of the Musculoskeletal System" are least often denied whereas those with diagnoses within the "Mental Illness" category are most often denied (compared with other diagnosis categories). Furthermore, private insurance holders are least often denied whereas "medicaid" holders are most often denied (compared with other insurance types). When analyzing facility-level factors, we found that the overall 5-star rating and urban versus rural status of an SNF are significantly related to referral acceptance (P<.05). We found a positive but nonmonotonic relationship between the 5-star rating and referral acceptance rates, with the highest acceptance rates found among 5-star facilities. In addition, we found that SNFs in urban areas have lower acceptance rates than their rural counterparts. CONCLUSIONS: While many factors may influence a referral acceptance, care challenges associated with individual diagnoses and financial challenges associated with different remuneration types were found to be the strongest drivers. Understanding these drivers is essential in being more intentional in the process of accepting or denying referrals. We have interpreted our results using an adaptive leadership framework and suggested how SNFs can be more purposeful with their decisions while striving to achieve appropriate occupancy levels in ways that meet their goals and patients' needs.


Assuntos
Hospitalização , Instituições de Cuidados Especializados de Enfermagem , Humanos , Estados Unidos , Estudos Retrospectivos , Medicaid , Assistência de Longa Duração , Alta do Paciente , Readmissão do Paciente
2.
Ultraschall Med ; 38(4): 395-402, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26251994

RESUMO

Purpose To explore the feasibility of transient elastography (TE) to quantify cervical stiffness changes during normal pregnancy and its spatial variability. Materials and Methods TE was used to quantify the cervical stiffness in four anatomical regions. 42 women between 17 and 43 years of age and at 6 - 41 weeks of gestation were studied. The stiffness was related to gestational age at the time of examination, interval from ultrasound examination to delivery and cervical length to evaluate the potential of TE to assess cervical ripening. In addition, a sensitivity analysis based on Cronbach's alpha coefficient was carried out to assess the concordance between inter/intra-operator measurements. Results There were significant correlations between cervical stiffness measured in the four regions with gestational age and the remaining time for delivery. Results confirm stiffness variability within the cervix. No significant association was found between cervical length and stiffness in the four ROIs. Associations between gestational age and remaining time for delivery with cervical length present weaker correlations than with cervical stiffness. The external part of the cervix was significantly softer than the internal one, and these stiffness values vary significantly in the anterior compared to the posterior cervix. The measurements taken by the same and by two different observers for different regions in the cervix were reliable and reproducible. Conclusion It is feasible to objectively quantify the decrease of cervical stiffness correlated to gestational age. Transient elastography is a valuable promising tool to provide additional information on the process of cervical effacement to that obtained from digital examination and conventional ultrasound. Further studies are needed to assess the feasibility of the technique in obstetric clinical applications, such as prediction of preterm birth or success in labor induction.


Assuntos
Maturidade Cervical , Colo do Útero , Técnicas de Imagem por Elasticidade , Adolescente , Adulto , Colo do Útero/diagnóstico por imagem , Feminino , Idade Gestacional , Humanos , Trabalho de Parto Induzido , Gravidez , Nascimento Prematuro , Adulto Jovem
3.
Cureus ; 16(4): e57988, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38738115

RESUMO

Acute idiopathic scrotal edema is a clinical entity predominant in children under 10 years whose true incidence is unknown in our setting. Diagnosis is challenging and avoids unnecessary surgeries. We present the case of an idiopathic acute scrotal edema with ultrasound findings highly suggestive of the diagnosis, which was managed conservatively with complete signs and symptoms resolution after discharge. We aim to review the ultrasound characteristics and differential diagnosis of this disorder.

4.
Front Psychol ; 15: 1336562, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38988400

RESUMO

Introduction: There are several risk factors associated with developing mental disorders among people over 60 years of age. Mental health encompasses multiple domains or capacities, which can comprise the psychological wellbeing of older people. Therefore, resilient coping, self-compassion, self-esteem, hopelessness, quality of life, and depression are considered the characteristics and adaptive mechanisms that bring together the main risk and protective factors for imbalance in mental wellbeing. Objective: This study aimed to establish the demographic, social, and family factors, as well as the clinical characteristics and lifestyle habits that influence the mental health of the elderly people in the city of Medellín, in the year 2021, to build a mental health index. Methodology: This study adopts a quantitative approach, employs retrospective temporality, and utilizes secondary sources. A cross-sectional survey was carried out with the SABAM Project (health and mental wellbeing of older adults from five cities in Colombia in 2021 by its Spanish acronym) database (secondary source), which is part of the research group "Public Health Observatory" of CES University (Medellín, Colombia). The database comprised 500 records of people aged over 60 years from the city of Medellín in 2021. While constructing the index, a principal component analysis was used, along with the Varimax method for factor analysis rotation. Results: The median age of the general population was 67 years (IQR 63-72); for men, the median age was 66 years (IQR 63-71) and for women, the median age was 67 years (IQR 63-72). An association was found between low socioeconomic levels, alcohol consumption, and the level of higher education (university-postgraduate) with low levels of the Mental Health Index in people over 60 years of age in Medellín during the year 2021. Conclusion: A quantitative model was developed to predict either a positive or negative prognosis in the mental wellbeing of the population over 60 years of age in the city of Medellín. The model was also used for the development of a sociodemographic profile highlighting the impact on mental health among people over 60 years of age with limited economic resources.

5.
Fetal Diagn Ther ; 34(4): 206-10, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24051494

RESUMO

OBJECTIVES: To describe the results of a technique of laser ablation of placental vessels in the treatment of severe twin-twin transfusion syndrome (TTTS), which is characterized by separation of the fetoplacental vascular territories and dichorionization of the placenta. PATIENTS AND METHODS: Descriptive analysis of TTTS cases treated with the endoscopic laser dichorionization of the placenta (ELDP) procedure. The variables evaluated were the occurrence of reversal of the donor-recipient phenotype, persistence of TTTS or twin anemia-polycythemia sequence (TAPS); gestational age at delivery; discharge from the hospital of at least 1 or 2 live neonates, and incidence of neurological alterations among survivors. RESULTS: 67 patients were treated with the ELDP procedure. There was no persistence of TTTS, reversal of the donor-recipient phenotype or TAPS. The median gestational age at delivery was 33.0 (23.6-37.7) weeks. The rate of discharge from the hospital of at least 1 or 2 live neonates was 88.2% (67/76) and 71.1% (54/76), respectively. Among survivors, 17 (17/121 = 14.0%) children presented with neurodevelopmental alterations during clinical follow-up. CONCLUSIONS: The major contribution of this study was the demonstration that the ELDP technique appears to be associated with a low risk of persistence or recurrence of TTTS and TAPS.


Assuntos
Córion/irrigação sanguínea , Córion/cirurgia , Transfusão Feto-Fetal/cirurgia , Terapia a Laser/métodos , Placenta/irrigação sanguínea , Placenta/cirurgia , Endoscopia/efeitos adversos , Endoscopia/métodos , Feminino , Morte Fetal/etiologia , Transfusão Feto-Fetal/complicações , Fetoscopia/efeitos adversos , Fetoscopia/métodos , Idade Gestacional , Humanos , Recém-Nascido , Terapia a Laser/efeitos adversos , Masculino , Doenças do Sistema Nervoso/etiologia , Gravidez , Resultado da Gravidez , Estudos Retrospectivos
6.
Am J Trop Med Hyg ; 2022 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-35292592

RESUMO

Histoplasmosis, one of the most frequent endemic mycoses in the Americas, is caused by the inhalation of airborne conidia of Histoplasma capsulatum. Better understanding of the distribution of this fungus in the environment is important for the development of appropriate public health measures to prevent human infections. Previously, we used Hc100 nested polymerase chain reaction (PCR) to identify H. capsulatum DNA in 10% of environmental samples in Colombia. Here, we validate a 100-kDa real-time PCR assay for the detection of this fungus in the environment. Using this method, we identified H. capsulatum DNA in 80% of samples of raw organic materials, such as chicken manure, soil from caves, and bird and bat guano, as well as in 62% of samples of organic fertilizer that underwent the composting process. We demonstrated that 100-KDa real-time PCR is a useful tool for environmental surveillance that can be used to identify the potential reservoirs of H. capsulatum and to prevent outbreaks, especially in people with the higher risk of exposure, such as spelunkers, farmers, poultry manure collectors, and anyone who handle organic fertilizers or bat and bird excreta.

7.
Heliyon ; 5(7): e02084, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31372546

RESUMO

The thermally dimorphic fungus Histoplasma capsulatum is the causative agent of histoplasmosis, one of the most prevalent endemic mycosis in the Americas. In tropical regions, agro-ecosystems require organic matter replacement, therefore, the use of organic fertilizers has increased disregarding the fact that certain number of such fertilizers might be contaminated with the fungus, and with their handling resulting in human cases and even outbreaks of histoplasmosis. Additionally, in Colombia, chicken manure is the most common raw material used in the production of organic fertilizers. In this work, we reported the isolation of this fungus from chicken manure, and genetically compared with 42 clinical isolates. The genetically compared environmental isolates grouped together with the clinical ones. Our result suggests that chicken manure may be one of H. capsulatum infection sources. Also, the phylogenetic analyses done with other H. capsulatum isolates indicate that the Colombian isolates are widely distributed in the relational tree thus reveling towards the great genetic diversity among the H. capsulatum Colombian isolates.

8.
Sci Rep ; 9(1): 11013, 2019 07 29.
Artigo em Inglês | MEDLINE | ID: mdl-31358849

RESUMO

Increasing heat stress due to global climate change is causing coral reef decline, and the Caribbean has been one of the most vulnerable regions. Here, we assessed three decades (1985-2017) of heat stress exposure in the wider Caribbean at ecoregional and local scales using remote sensing. We found a high spatial and temporal variability of heat stress, emphasizing an observed increase in heat exposure over time in most ecoregions, especially from 2003 identified as a temporal change point in heat stress. A spatiotemporal analysis classified the Caribbean into eight heat-stress regions offering a new regionalization scheme based on historical heat exposure patterns. The temporal analysis confirmed the years 1998, 2005, 2010-2011, 2015 and 2017 as severe and widespread Caribbean heat-stress events and recognized a change point in 2002-2004, after which heat exposure has been frequent in most subsequent years. Major heat-stress events may be associated with El Niño Southern Oscillation (ENSO), but we highlight the relevance of the long-term increase in heat exposure in most ecoregions and in all ENSO phases. This work produced a new baseline and regionalization of heat stress in the basin that will enhance conservation and planning efforts underway.


Assuntos
Mudança Climática , Recifes de Corais , Animais , Antozoários/fisiologia , Região do Caribe , Conservação dos Recursos Naturais , El Niño Oscilação Sul , Monitoramento Ambiental , Resposta ao Choque Térmico
9.
Rev Salud Publica (Bogota) ; 10(4): 633-42, 2008.
Artigo em Espanhol | MEDLINE | ID: mdl-19360213

RESUMO

OBJECTIVES: Determining the prevalence of intestinal parasitism and identifying the associated risk factors in the village of Loma Arena, Bolivar department, Colombia. METHODOLOGY: The community's sanitary and educational conditions were evaluated by using a questionnaire which was applied to each family group. Two stool samples obtained by spontaneous evacuation, on two different days, were gathered from each participating person for the coproparasitological study. The coprological test involved direct examination in saline physiological solution and temporary staining with Lugol's solution and the formol-ether concentration method. RESULTS: It was found that 92 % of the population was parasitised, 92 % of them with at least one pathogenic parasite. Polyparasitism was very important (89,2 %); a maximum of 7 species per host was found. Helminth and protozoa coinfection was frequent (64 %). There was only 0,9 % teniosis prevalence. There was a significant association between symptomatology and parasite presence (p< 0.05), though such relationship was not seen with potentially pathogenic parasites (with the exception of Trichuris trichura and abdominal pain). The statistical analysis did not reveal any relationship between parasitism and educational level or sanitary habits. CONCLUSION: The uniform distribution of most intestinal parasites amongst the five age-groups evaluated showed that people in Loma Arena were evenly exposed to sources of infection in all age-groups.


Assuntos
Enteropatias Parasitárias/epidemiologia , Adolescente , Adulto , Ascaríase/epidemiologia , Criança , Pré-Escolar , Colômbia/epidemiologia , Interpretação Estatística de Dados , Entamebíase/epidemiologia , Feminino , Helmintíase/epidemiologia , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Prevalência , Infecções por Protozoários/epidemiologia , Fatores Socioeconômicos , Tricuríase/epidemiologia
10.
Atherosclerosis ; 277: 434-439, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30270082

RESUMO

BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is characterized by elevated serum cholesterol levels due to high low-density lipoprotein (LDL) cholesterol levels. FH is an autosomal dominant genetic disorder and one of the most common dominant hereditary diseases in the world. However, the frequency of mutations in Colombia is unknown. The purpose of this preliminary study was to identify mutations in the LDL receptor (LDLR) gene in a Colombian population with FH. METHODS: The study included 24 families with clinical diagnosis of sure/probable FH. The 18 exons of the LDLR were sequenced by Sanger method. RESULTS: Among 18 variants identified, 3 were known pathogenic mutations and were identified in nine individuals in five unrelated families. Five affected individuals were heterozygous for one mutation each. They were the p.W4X in two, the p.D139G in two and the p.G396D in one. Two affected individuals were homozygous for p.G396D. The variant c.1187-1G > T, which has uncertain significance in FH pathogenesis, was present in all the individuals with the p.D139G mutation. CONCLUSIONS: In total, 18 variants were identified, of which 14 correspond to known nonpathogenic variants. Three pathogenic variants were identified in the LDLR. No pathological mutations were identified in the LDLR in 79% of the study population.


Assuntos
LDL-Colesterol/sangue , Análise Mutacional de DNA , Hiperlipoproteinemia Tipo II/genética , Mutação , Receptores de LDL/genética , Adolescente , Adulto , Idoso , Anticolesterolemiantes/uso terapêutico , Biomarcadores/sangue , Colômbia , Quimioterapia Combinada , Feminino , Predisposição Genética para Doença , Hereditariedade , Heterozigoto , Homozigoto , Humanos , Hiperlipoproteinemia Tipo II/sangue , Hiperlipoproteinemia Tipo II/diagnóstico , Hiperlipoproteinemia Tipo II/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Taxa de Mutação , Linhagem , Fenótipo , Dados Preliminares , Adulto Jovem
11.
J Infect Public Health ; 11(4): 558-565, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29292044

RESUMO

BACKGROUND: Dengue fever is a priority problem for public health in Colombia. The Department of Tolima and the municipality of El Espinal bring a considerable proportion of the cases to national statistics, becoming a representative area for studying the behavior of this pathology. OBJECTIVE: Determine the epidemiological behavior and the geographic distribution of dengue fever cases treated in the San Rafael Hospital in the municipality of the El Espinal, from 2010 to 2014. MATERIALS AND METHODS: The following is a retrospective cross-sectional case report study of the population with dengue fever treated in San Rafael Hospital. We analyzed data from the mandatory clinical reports of the SIVIGILA (National public health surveillance system, in Spanish) using Excel, EpiInfo and EpiMap were analyzed. The epidemiological analysis encompassed morbidity, mortality, fatality, endemicity and cartograms of georeferencing, among others. RESULTS: The totality of cases was 3264, with an incidence of 5.84 per 1000 inhabitants, mortality of 0.12 cases per 10,000 inhabitants, and lethality of 0.11 per 100 diagnosed cases. 71.6% of the patients were between 1 and 24 years, 53.8% were male and 46.2% female. The endemic behaviour was bimodal, Max in epidemiological periods 3-4 and 12-13. The distribution geographic of cases spanned the whole of the municipality and is related apparently with the population density in an area defined. CONCLUSIONS: The results found are above local, national and international parameters on incidence, mortality, and case-fatality. Through the analysis of endemic behavior and geographic distribution, times and specific areas are provided to optimize public health measures.


Assuntos
Dengue/epidemiologia , Doenças Endêmicas/estatística & dados numéricos , Saúde Pública/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Colômbia/epidemiologia , Estudos Transversais , Dengue/diagnóstico , Dengue/mortalidade , Dengue/terapia , Feminino , Geografia , Hospitais/estatística & dados numéricos , Humanos , Incidência , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
12.
Am J Trop Med Hyg ; 98(5): 1303-1312, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29532772

RESUMO

Histoplasma capsulatum is the causative agent of histoplasmosis and this fungus inhabits soils rich in phosphorus and nitrogen that are enriched with bird and bat manure. The replacement of organic matter in agroecosystems is necessary in the tropics, and the use of organic fertilizers has increased. Cases and outbreaks due to the presence of the fungus in these components have been reported. The Instituto Colombiano Agropecuario resolution 150 of 2003 contains the parameters set by the Colombian Technical Standard (NTC 5167) on the physicochemical and microbiological features of fertilizers, but it does not regulate the search for H. capsulatum. The aim of this study was to demonstrate H. capsulatum presence in organic fertilizers by nested polymerase chain reaction (PCR). A total of 239 samples were collected: 201 (84.1%) corresponded to organic fertilizers, 30 (12.5%) to bird excrement, and 8 (3.4%) to cave soils. The Hc100 nested PCR had a detection limit of 0.1 pg/µL and a specificity of 100%. A total of 25 (10.5%) samples were positive and validated by sequencing. Seven of the positive samples represented locations where H. capsulatum was previously detected, suggesting the persistence of the fungus. No significant correlations were detected between the physicochemical and microbiological parameters with the presence of H. capsulatum by nested PCR, indicating the fungus existence in organic fertilizers that complied with the NTC 5167. The Hc100 nested PCR targeting H. capsulatum standardized in this work will improve the evaluation of organic fertilizers and ensure the prevention of outbreaks and cases due to manufacturing, marketing, and use of fertilizers contaminated with H. capsulatum.


Assuntos
Fertilizantes , Histoplasma/isolamento & purificação , Reação em Cadeia da Polimerase/métodos , Animais , Galinhas , Colômbia , DNA Fúngico/genética , Histoplasma/genética , Esterco/análise , Esterco/microbiologia , Metais Pesados/química
13.
Rev. Investig. Innov. Cienc. Salud ; 4(2): 121-136, 2022. tab, ilus
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1419007

RESUMO

Introducción. La diabetes mellitus (DM) es una de las enfermedades crónicas más comunes, siendo una de las causas principales de mortalidad de la población mun-dial. La dermatoglifia es empleada como instrumento para el hallazgo de ciertos aspectos biológicos en diferentes poblaciones. Objetivo. Reconocer, a partir de una revisión sistemática, la relevancia que tiene la dermatoglifia como medio de hallazgo de diabetes mellitus. Metodología. Revisión de literatura científica en bases de datos como Sciencedi-rect, PubMed, Scopus y BVS, en las cuales se extrajo información después de co-rrer la ecuación de búsqueda con términos MESH. Posteriormente, fueron revisados para incluir aquellos artículos relacionados con DM y dermatoglifia. Para todo el proceso se siguió la metodología PRISMA, evaluando los artículos con la escala de sesgo de Cochrane y el nivel de evidencia y recomendación con escala SIGN. Resultados. Después de una revisión de 475 artículos, se incluyeron ocho artículos, y al ser evaluados fueron clasificados cinco artículos 2+ y tres 2-, con nivel de reco-mendación D. Conclusión. La dermatoglifía es una herramienta útil como medio de detección de la DM. Sin embargo, es necesario realizar estudios de cohortes para demostrarlo en di-ferentes poblaciones, como la colombiana. En ese sentido, se encuentra que el 70% de los artículos revisados demuestran que la predicción de hallazgo de DM es efectiva. Sin embargo, el 30% de las investigaciones dentro de esta revisión no consideran que sea una herramienta lo suficientemente óptima para descubrir la patología en la población.


Introduction. Diabetes mellitus (DM) is one of the most common chronic diseases, be-ing one of the main causes of mortality in the world population. Dermatoglyphics is used as an instrument for the discovery of certain biological aspects in different populations.Objective. To recognize, by doing a systematic review, the relevance of dermato-glyphics as a means of finding diabetes mellitus. Methodology. Review of scientific literature in databases such as Sciencedirect, PubMed, Scopus, and VHL, in which information was extracted after running the search equation with MESH terms. After that, they were revised to include those articles related to DM and dermatoglyphics. For the entire process, the PRISMA methodology was followed, evaluating the articles with the Cochrane bias scale and the level of evidence and recommendation with the SIGN scale. Results. After a review of 475 articles, eight articles were included, and when evalu-ated, five articles were classified as 2+ and three as 2-, with a level D recommendation. Conclusion. Dermatoglyphics is a useful tool as a means of detecting DM. However, it is necessary to carry out cohort studies to demonstrate this in different populations, such as the Colombian population. 70% of the reviewed articles show that the prediction of DM finding is effective. Nevertheless, 30% of the investigations within this review do not consider it to be a sufficiently optimal tool to discover the pathology in the population


Assuntos
Dermatoglifia , Diabetes Mellitus , Doença Crônica , Causalidade , Estudos de Coortes , Predisposição Genética para Doença , Medical Subject Headings , Diagnóstico , Metodologia como Assunto , Revisão Sistemática
14.
Rev Alerg Mex ; 63(4): 373-384, 2016.
Artigo em Espanhol | MEDLINE | ID: mdl-27795218

RESUMO

Angioedema is defined as edema of the skin or mucosa, including the respiratory and the gastrointestinal mucosa, which is self-limiting, and in most cases is completely resolved in less than 72 hours. It occurs due to increased permeability of the mucosal and submucosal capillaries and postcapillary venules, with resulting plasma extravasation. There are different types of angioedema: histaminergic (which may be mediated by immunoglobulin E), hereditary, from acquired C1 inhibitor deficiency, from angiotensin converting enzyme inhibitor, bradykinin-mediated, and non-histaminergic idiopathic angioedema. Treatment depends on the cause of angioedema, age, and the frequency and severity of manifestations. The main measures are avoiding external triggers or causes, giving antihistamines, steroids, or adrenaline for histaminergic angioedema; replacing the deficient protein or blocking the action of bradykinin in C1 inhibitor deficiency and angioedema from angiotensin converting enzyme inhibitor.


El angioedema se define como el edema de piel o mucosas, incluidas las de los tractos respiratorio y gastrointestinal, de carácter autolimitado, que en la mayoría de los casos se resuelve en forma completa en menos de 72 horas. Ocurre por aumento de la permeabilidad de los capilares mucosos, submucosos y vénulas poscapilares, con la consiguiente extravasación del plasma. Existen diferentes tipos de angioedema: el histaminérgico (que puede ser mediado o no por inmunoglobulina E), el hereditario, por déficit de C1 inhibidor adquirido, por inhibidores de la enzima convertidora de la angiotensina, mediados por bradiquininas y el angioedema no histaminérgico idiopático. El tratamiento depende de la causa del angioedema, la edad, frecuencia y gravedad de sus manifestaciones. Las principales medidas son evitar los desencadenantes o disparadores externos, la administración de antihistamínicos, esteroides o adrenalina en el angioedema histaminérgico; el reemplazo de la proteína deficiente o el bloqueo de la acción de la bradiquinina en el déficit de C1 inhibidor y en el angioedema por inhibidores de la enzima convertidora de la angiotensina.


Assuntos
Angioedema , Fatores Etários , Angioedema/classificação , Angioedema/etiologia , Angioedema/terapia , Angioedemas Hereditários/etiologia , Inibidores da Enzima Conversora de Angiotensina/efeitos adversos , Bradicinina/antagonistas & inibidores , Permeabilidade Capilar , Humanos , Vênulas
16.
Rev. colomb. anestesiol ; 46(3): 216-221, July-Sept. 2018. tab, graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-959808

RESUMO

Abstract Introduction: Administrating intravenous fluids is one of the most frequent practices in the care of critically ill patients, since most of them present shock or hypotension from any cause. The rapid and aggressive administration of these fluids may lead to adverse results, including acute renal failure and hydroelectrolytic disorders which are highly associated with fatal outcomes. Objectives: To establish the association between hyperchloremia and mortality in patients admitted to the intensive care unit (ICU) of Hospital Universitario de San José between August 2013 and January 2017, in addition to their demographic characteristics, the incidence of chloride abnormalities, and its association to renal failure. Methods: Analytic retrospective cohort study in the adult ICU at the Hospital Universitario de San José from August 1, 2013 to January 31, 2017. Results: A total of 839 patients were evaluated, 210 exposed and 629 not exposed. The relative risk of death for those who developed hyperchloremia was 3.12 (95% confidence interval [CI] 2.16^.49) (P <0.001). The multivariate analysis generated an hazard ratio of 2.31 (95% CI 1.47-3.63) adjusted for age, sex, APACHE II at admission, sepsis, neurocritical state, and development of renal failure. Conclusion: Hyperchloremia is a frequent event in patients in the ICU; it may act as an independent variable for mortality in critical patients.


Resumen Introducción: La administración de líquidos endovenosos es de los actos que con mayor frecuencia se realizan en el cuidado de los pacientes críticamente enfermos, dado que gran parte de los mismos cursan con choque o hipotensión de cualquier causa, ésta se realiza de forma agresiva y rápida, dicha administración puede conllevar a eventos desfavorables como la falla renal aguda y alteraciones hidroelectrolíticas que están altamente relacionadas con desenlaces fatales. Objetivos: Establecer la asociación entre hipercloremia y mortalidad en los pacientes hospitalizados en cuidados intensivos del hospital Universitario de San José entre agosto de 2013 y enero de 2017, así como sus características demográficas, incidencia de anormalidades del cloro y su asociación con falla renal. Métodos: Estudio analítico de cohortes retrospectiva, en la Unidad de Cuidados intensivos (UCI) adultos del Hospital Universitario de San José, en el período comprendido entre el 1 de agosto de 2013 y el 31 de enero de 2017. Resultados: Fueron evaluados 839 pacientes, 210 expuestos y 629 no expuestos. El riesgo relativo para muerte en los que desarrollaron hipercloremia fue 3.12 (IC95% 2.16-4.49) (p <0.001). En el análisis multivariado se obtuvo un HR de 2.31 (IC95% 1.473.63) ajustado por las variables de edad, sexo, APACHE II al ingreso, sepsis, estado neurocrítico y desarrollo de falla renal. Conclusiones: La hipercloremia es un evento frecuente durante la atención de los pacientes en la unidad de cuidados intensivos; puede actuar como una variable independiente de mortalidad en los pacientes críticos.


Assuntos
Humanos
18.
J Child Orthop ; 2(6): 425-9, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19308538

RESUMO

PURPOSE: Legg-Calvé-Perthes disease is an idiopathic avascular necrosis of the femoral head. Although many surgical approaches to treat the late presentation of this pathology have been proposed, there are few reports about the early results of the double osteotomy procedure (femoral varus osteotomy combined with Salter innominate osteotomy). The purpose of this study was to describe the early results obtained with the double osteotomy in patients with late presentation of Legg-Calvé-Perthes disease. METHODS: Cross-sectional evaluation of ten patients intervened with double osteotomy. There were seven males and three females with a mean age of 9.2 +/- 1.7 years [standard deviation (SD)]. The average post-surgical time of evaluation was of 46.5 +/- 26.2 months. RESULTS: Of the ten evaluated patients, four had a Catterall III and six had a Catterall IV disease. According to Herring classification, three patients were Herring B and seven were Herring C. The epiphyseal extrusion average before and after the surgical procedure was 19.3 +/- 12.4 and 12.1 +/- 14.9%, respectively. In accordance with the Ratliff classification and Lloyd Roberts radiological results, the following were the postoperative clinical results: four good, five fair and one poor. Based on the Stulberg classification, there was one patient in class I, five in class II, three in class III and one in class IV. CONCLUSION: The surgical treatment for late Perthes disease with the best expected outcome is still a challenge. According to the resultsreported here, the double osteotomy could be considered as an alternative to treat this entity.

20.
Rev. argent. ultrason ; 13(4): 326-330, dic. 2014. ilus
Artigo em Espanhol | LILACS | ID: lil-763815

RESUMO

Se presenta el caso de una paciente con síndrome pilórico postcolecistectomía de posible origen iatrogénico, sospechándose oblito quirúrgico. En el presente trabajo se destaca la importancia de la ecografía, como método inicial, en su diagnóstico presuntivo, en pacientes con antecedentes quirúrgicos.


Assuntos
Humanos , Adulto , Feminino , Corpos Estranhos/diagnóstico , Corpos Estranhos , Ultrassonografia
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