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1.
BMC Oral Health ; 23(1): 389, 2023 06 14.
Artigo em Inglês | MEDLINE | ID: mdl-37316791

RESUMO

OBJECTIVE: To compare effectiveness of counselling program versus counselling program plus jaw exercises to reduce pain and click in patients with temporomandibular joint disc displacement with reduction (DDWR). MATERIALS AND METHODS: Patients were divided into two groups: instructions for temporomandibular disorders (TMD) plus jaw exercises (test, n = 34), only TMD instructions (control, n = 34). Pain was analyzed by palpation (RDC/TMD). It was investigated if the click caused discomfort. Both groups were evaluated at baseline, 24 h, 7 days, and 30 days' post treatment. RESULTS: The click was present in 85.7% (n = 60). In 30-day evaluation, there was a statistically significant difference between groups in the right median temporal muscle (p = 0.041); and there was a statistically significant difference in treatment self-perception (p = 0.002) and click's discomfort (p < 0.001). CONCLUSION: The exercise with recommendations showed better results, resolution of the click, and self-perception of the treatment effectiveness. CLINICAL RELEVANCE: This study presents therapeutic approaches that are easy to perform and that can be monitored remotely. In view of the current stage of the global pandemic, these treatment options become even more valid and useful. CLINICAL TRIAL REGISTER: This clinical trial was registered at Brazilian Clinical Trials Registry (ReBec) under protocol RBR-7t6ycp ( http://www.ensaiosclinicos.gov.br/rg/RBR-7t6ycp/ ), Date of registration: 26/06/2020.


Assuntos
Terapia por Exercício , Transtornos da Articulação Temporomandibular , Humanos , Aconselhamento , Exercício Físico , Pacientes , Brasil , Dor , Transtornos da Articulação Temporomandibular/terapia
2.
Comput Inform Nurs ; 40(12): 825-835, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36516033

RESUMO

Anxiety disorders are among the most prevalent mental disorders worldwide. However, anxiety is not exclusive to anxiety disorders. In fact, the nursing discipline approaches anxiety as a human response to health conditions/life processes. Health information systems should primarily contribute to improving the quality of care, patient safety, and the effectiveness of care delivery. Nevertheless, nursing information systems still fail to incorporate evidence-based clinical data models addressing the nursing focus "anxiety." Thus, this study aimed to obtain consensus on the data to be included in a clinical data model addressing the nursing focus "anxiety," its organization, and its interrelationships by using a brainstorming session and a modified e-Delphi technique with a panel of nurse experts from across Portugal. Eight experts participated in the brainstorming session. A total of 59 and 54 participants completed the survey in e-Delphi rounds 1 and 2, respectively. Consensus was achieved to all data presented to the participants, and these data were later included in the clinical data model. This evidence-based clinical data model, grounded on a nursing theory and with standardized nursing language, will substantially contribute to nursing documentation and, consequently, to nursing care targeted at patients with anxiety.


Assuntos
Transtornos de Ansiedade , Segurança do Paciente , Humanos , Consenso , Técnica Delphi , Inquéritos e Questionários
3.
J Clin Periodontol ; 48(4): 541-549, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33474762

RESUMO

AIM: This cross-sectional study sought to investigate the factors possibly related to the impact caused by the coronavirus disease 2019 pandemic in the practice of periodontists, in two countries. MATERIALS AND METHODS: A total of 254 periodontists with active periodontics licensing in Brazil and the United States participated in the survey. Data were collected through an online questionnaire and the dependent variable was the perceived impact of the pandemic on periodontists' practice routines. Odds ratios were assessed by logistic regression analysis. RESULTS: Periodontists in private practice were 83% less likely to report a significant impact of the pandemic on their clinical routine as compared with professionals who work in the public sector or in academic institutions (CI 95%: 0.05-0.47). The financial impact of the pandemic was significantly associated with a perceived severe impact of the pandemic on their routines (OR: 1.36; CI 95%: 1.16-1.61). Professionals who have enhanced their hand-washing routine were more likely to report a significant impact of the pandemic by 3.41 times (CI 95%: 1.28-9.04) relative to those who have not altered their hand-washing protocols. CONCLUSION: The pandemic is associated with a negative impact on the practice of periodontists, especially those working in public sectors and academic institutions.


Assuntos
COVID-19 , Pandemias , Brasil/epidemiologia , Estudos Transversais , Humanos , SARS-CoV-2 , Inquéritos e Questionários , Estados Unidos
4.
J Oral Rehabil ; 48(4): 369-374, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33206400

RESUMO

OBJECTIVE: The aim of this study was to compare the effectiveness of two types of treatment (counselling programme versus counselling programme plus jaw exercises) to improve the quality of life of patients with disc displacement with reduction (DDWR). MATERIALS AND METHODS: Patients were divided into two groups. The test group received guidelines for temporomandibular disorders (TMD) plus jaw exercises for DDWR, and the control group received only guidelines for TMD. The total number of investigated patients was 70, thus 35 per group. The oral health-related quality of life was assessed by the OHIP-14 questionnaire. Both groups were evaluated at the baseline and 30 days post-treatment. RESULTS: In the counselling group, there was statistically significant decrease in pain (P = .015) and social disability (P = .046) subscales. In the counselling plus jaw exercise group, there was statistically significant decrease in all subscales (P < .05). At 30 days follow-up, there was a statically significant difference between the two groups in pain (P = .004), psychological discomfort (P < .001), psychological disability (P < .001) and social disability (P = .029) subscales. CONCLUSION: The counselling programme plus jaw exercise protocol showed greater improvement in oral health-related quality of life than the group performing only the counselling programme in patients with DDWR.


Assuntos
Luxações Articulares , Transtornos da Articulação Temporomandibular , Aconselhamento , Terapia por Exercício , Humanos , Qualidade de Vida , Inquéritos e Questionários , Transtornos da Articulação Temporomandibular/terapia
5.
BMC Oral Health ; 20(1): 116, 2020 04 16.
Artigo em Inglês | MEDLINE | ID: mdl-32299404

RESUMO

BACKGROUND: The biologic width is defined as the coronal dimension to the alveolar bone that is occupied by healthy gingival tissue. The objective of the present study was to correlate radiographic findings of biologic width invasion with the periodontium status. METHODS: It were included 14 patients with restored teeth with biological width invasion, on the proximal sites, observed clinically and radiographically. 122 proximal sites were evaluated, 61 in the test group (biological width invasion) and 61 in the control group (adequate biological width). Smokers and patients presenting periodontal disease or restorations with contact in eccentric movements, horizontal over-contour or secondary caries were excluded from the sample. The invasion of the biologic width was diagnosed when the distance from the gingival margin of restoration to the bony crest was less than 3 mm. Intrabony defect and bone crest level, as well as, their vertical and horizontal components were radiographically evaluated when present. Plaque index, bleeding on probing, probing depth, gingival recession height, keratinized gingival height and thickness, and clinical attachment level were clinically evaluated. Data were subjected to Spearman's Correlation and Wilcoxon's test. RESULT: The most prevalent tooth with biological width invasion was the first molar. There was a statistically significant correlation between the bone crest (p < 0.001), vertical (p < 0.001) and horizontal (p = 0.001) components. In the test group, there was a statistically significant correlation between bleeding on probing (p < 0.001; r = 0.618) and width of gingival recession (p = 0.030; r = - 0.602) with the intraosseous component; and between keratinized gingival height and bone level (p = 0.037; r = - 0.267). In the control group, there was a correlation between plaque index (p = 0.027; r = - 0.283) with bone level and correlation between keratinized gingival thickness and bone level (p = 0.034; r = - 0.273) and intrabony component (p = 0.042; r = 0.226). CONCLUSION: A statistically significant relationship was found between bleeding on probing and gingival recession in patients who presented intrabony defects due to the invasion of biological width, which may be also related to the thickness of the keratinized gingiva.


Assuntos
Perda do Osso Alveolar/diagnóstico por imagem , Produtos Biológicos , Retração Gengival/diagnóstico por imagem , Periodonto/patologia , Adulto , Perda do Osso Alveolar/etiologia , Estudos de Casos e Controles , Índice de Placa Dentária , Feminino , Seguimentos , Gengiva/diagnóstico por imagem , Gengiva/patologia , Retração Gengival/etiologia , Retração Gengival/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Perda da Inserção Periodontal/diagnóstico por imagem , Perda da Inserção Periodontal/etiologia , Periodontite/diagnóstico por imagem , Periodontite/etiologia , Prevalência , Radiografia
6.
J Periodontal Res ; 54(4): 349-355, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30656679

RESUMO

BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the angiogenesis and lymphangiogenesis in gingival tissue biopsy specimens of individuals with clinically healthy gingiva, chronic gingivitis, and chronic periodontitis (n = 30 per clinical condition). MATERIAL AND METHODS: Histological sections were stained using hematoxylin and eosin as well as immunohistochemically with hematopoietic progenitor cell antigen CD34 and podoplanin (PDPN) antibodies to evaluate the microvascular count, area, and perimeter of blood and lymphatic vessels, respectively. RESULTS: The results revealed a correlation between the microvascular count of blood and lymphatic vessels (P = 0.03; however, in individuals with chronic periodontitis, fewer lymphatic vessels were present than in the clinically healthy gingival tissue (P = 0.01), which was not observed in the case of microvascular area and perimeter. Podoplanin labeling was present in the epithelium, and the intensity of labeling was positively correlated to the intensity of the inflammatory infiltrate (P = 0.03). CONCLUSION: In this study, we concluded that an increase in the number of blood and lymphatic vessels was not observed in bouth gingivitis and periodontitis samples. Podoplanin expression is highly associated with an increased inflammatory infiltration suggesting that PDPN might play an additional role in periodontal disease, other than solely as a lymphangiogenesis marker.


Assuntos
Antígenos CD34/metabolismo , Periodontite Crônica/metabolismo , Gengiva/metabolismo , Gengivite/metabolismo , Glicoproteínas de Membrana/metabolismo , Adulto , Biomarcadores/metabolismo , Epitélio/metabolismo , Feminino , Gengiva/irrigação sanguínea , Humanos , Imuno-Histoquímica , Linfangiogênese , Masculino , Pessoa de Meia-Idade , Neovascularização Patológica/metabolismo , Adulto Jovem
7.
Acta Odontol Scand ; 77(3): 219-223, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30646808

RESUMO

OBJECTIVE: This study aimed to identify and compare the self-reported and diagnosed prevalence of dentinal hypersensitivity (DH) in an University population; and to verify accuracy, sensitivity and specificity of DH stimuli tests. MATERIAL AND METHODS: Three hundred and eighty patients (67.2% women and 32.8% men) were assessed by questionnaire, clinical exam, tactile and cold water tests. The intensity of DH was assessed using a visual analogue scale, and a calibrated examiner measured the scores using a caliper. The ICC for intra-examiner was 0.990. Scores above 5 mm were considered sensitive teeth. The association between variables was assessed by Chi-square test. ROC curve analysis determined accuracy, sensitivity and specificity of the tests (p < .05). RESULTS: The mean age of participants was 24.08 years. 158 (41.7%) volunteers self-reported the presence of DH, while, 88.7% of the participants were clinically diagnosed (p = .023). In total, 8958 teeth were evaluated, of those 3367 (37.6%) were diagnosed sensitive. The most prevalent teeth with DH were incisors and premolars. The accuracy of the tests with cold water and tactile were 99%. The sensitivity and specificity for cold water and tactile tests were 99.9%, 99.7%, 99.1% and 87.6%, respectively. CONCLUSION: The self-reported prevalence of DH was significantly lower than that clinically diagnosed. The cold test proved to be a highly accurate stimulus for the diagnosis of DH.


Assuntos
Sensibilidade da Dentina/diagnóstico , Sensibilidade da Dentina/epidemiologia , Nível de Saúde , Saúde Bucal , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Prevalência , Autorrelato , Inquéritos e Questionários , Adulto Jovem
8.
BMC Oral Health ; 18(1): 155, 2018 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-30176855

RESUMO

BACKGROUND: This cross-sectional study aimed to identify the factors associated to the cervical dentin hypersensitivity (DH) in Brazilian adult population. METHODS: Three hundred and eighty patients (67.2% women and 32.8% men) were assessed by questionnaire and thermal test with ice. Participants marked in a visual analogue scale (VAS) the intensity of pain, and a calibrated examiner (ICC 0.990) measured the scores using a caliper. Pain scores above 0.5 mm were considered sensitive teeth. The DH associated factors were investigated by clinical examination. The association between variables was assessed by Spearman correlation and the Chi-square test. Logistic regression was used to determine the variables that predict DH (p < 0.05). RESULTS: The mean age of participants was 24.08 years. In this population, 8958 teeth were evaluated, of those 3037 (33.9%) were diagnosed sensitive. The most prevalent associated factors to DH were abnormal tooth positioning (9.0%), occlusal trauma (6.5%) and gingival recession (5.6%). The erosion predicted significantly the DH on both simple (OR 7.85, p < 0.001) and multiple(OR 4.36, p < 0.001) analysis. CONCLUSION: The exposure of dentinal tubules by erosion is probably the major predictor of dentin hypersensitivity. The healthy tooth is able to protect against DH.


Assuntos
Sensibilidade da Dentina/diagnóstico , Sensibilidade da Dentina/etiologia , Brasil , Estudos Transversais , Feminino , Humanos , Masculino , Medição da Dor , Fatores de Risco , Inquéritos e Questionários , Adulto Jovem
9.
Med Probl Perform Art ; 33(1): 1-5, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29600302

RESUMO

OBJECTIVE: The aim of the present study was to identify the prevalence of orofacial changes and factors associated with the frequent playing of wind instruments by musicians in Diamantina, Minas Gerais, Brazil. METHODS: A cross-sectional study was conducted with 40 professional musicians who played wind instruments. The musicians filled out questionnaires about their habits and musical career. The Research Diagnostic Criteria were applied to investigate temporomandibular disorders. Other oral parameters examined included periodontal status, plaque index, and decayed, missing, and filled teeth (DMF) index. A significance level of p<0.05 was adopted for statistical analysis. RESULTS: The population included 22 (55%) men and 18 (45%) women, with a mean age of 25.88 yrs. The most common instruments played were the saxophone (n=12, 30%), clarinet (n=9, 22.5%), and flute (n=6, 15%). The most frequent pain complaint after playing was numbness in the upper lip or no sensation (25% of musicians), and the most frequent dental change observed was inclination of the upper teeth (15% of musicians). There was no significant association between dental changes, pain, and classification of instrument type. CONCLUSION: The main oral change that affected musicians who played wind instruments was the inclination of anterior teeth.


Assuntos
Lábio/fisiopatologia , Músculo Masseter/fisiopatologia , Doenças Profissionais/fisiopatologia , Dor/etiologia , Adulto , Brasil , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Projetos Piloto , Prevalência , Adulto Jovem
10.
J Asthma ; 54(6): 624-631, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27780380

RESUMO

OBJECTIVES: To evaluate limited English proficiency (LEP) Latino caregiver asthma knowledge after exposure to an educational video designed for this target group. METHODS: A cross-sectional, interventional study was performed. We aimed to evaluate the post-test impact on asthma knowledge from baseline after exposure to a patient-centered, evidence-based, and professionally produced Spanish asthma educational video. Participants included LEP Latino caregivers of children 2-12 years old with persistent asthma. Enrollment was performed during ED encounters or scheduled through a local community organization. Asthma knowledge was measured with a validated Spanish parental asthma knowledge questionnaire. Differences in mean scores were calculated with a paired t-test. RESULTS: Twenty caregivers were enrolled. Participants included mothers (100%) from Puerto Rico (75%), with a high-school diploma or higher (85%), with no written asthma action plan (65%), whose child's asthma diagnosis was present for at least 3 years (80%). Mean baseline asthma knowledge scores improved 8 points from 58.4 to 66.4 after watching the educational video (95% CI 5.3-10.7; t(19) = 6.21, p < 0.01). Knowledge improvements were similar across the ED and community groups. Knowledge gains were observed in the areas of ED utilization, medication usage, and activity limitations. CONCLUSIONS: The developed educational video improved caregiver asthma knowledge for a Latino population facing communication barriers to quality asthma care. Dissemination of this educational resource to LEP caregivers has the potential to improve pediatric asthma care in the United States.


Assuntos
Asma/fisiopatologia , Barreiras de Comunicação , Educação em Saúde/métodos , Conhecimentos, Atitudes e Prática em Saúde , Mães/psicologia , Adulto , Antiasmáticos/uso terapêutico , Asma/tratamento farmacológico , Criança , Pré-Escolar , Estudos Transversais , Serviço Hospitalar de Emergência/estatística & dados numéricos , Feminino , Hispânico ou Latino , Humanos , Internet , Idioma , Masculino , Pessoa de Meia-Idade , Porto Rico/etnologia , Fatores Socioeconômicos
11.
Molecules ; 22(7)2017 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-28671567

RESUMO

Diacronema vlkianum is a marine microalgae for which supposed health promoting effects have been claimed based on its phytochemical composition. The potential use of its biomass as health ingredient, including detox-shakes, and the lack of bioavailability studies were the main concerns. In order to evaluate the microalgae-biomass assimilation and its health-benefits, single-dose (CD1-mice) studies were followed by 66-days repeated-dose study in Wistar rats with the highest tested single-dose of microalgae equivalent to 101 mg/kg eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA). Microalgae-supplementation modulated EPA and docosapentaenoic acid enrichment at arachidonic acid content expenditure in erythrocytes and liver, while increasing EPA content of heart and adipose tissues of rats. Those fatty acid (FA) changes confirmed the D. vlkianum-biomass FA assimilation. The principal component analyses discriminated brain from other tissues, which formed two other groups (erythrocytes, liver, and heart separated from kidney and adipose tissues), pointing to a distinct signature of FA deposition for the brain and for the other organs. The improved serum lipid profile, omega-3 index and erythrocyte plasticity support the cardiovascular benefits of D. vlkianum. These results bolster the potential of D. vlkianum-biomass to become a "heart-healthy" food supplement providing a safe and renewable source of bioavailable omega-3 FA.


Assuntos
Ácidos Docosa-Hexaenoicos/química , Ácido Eicosapentaenoico/química , Ácidos Graxos/análise , Haptófitas/química , Microalgas/química , Tecido Adiposo/química , Animais , Organismos Aquáticos/química , Biomassa , Suplementos Nutricionais/análise , Eritrócitos/química , Fígado/química , Masculino , Miocárdio/química , Ratos , Ratos Wistar
13.
J Asthma ; 52(1): 71-80, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25019349

RESUMO

OBJECTIVE: To assess limited English proficiency (LEP) asthma caregiver quality of life (QoL), skills retention and healthcare utilization after an asthma education fair (AEF). METHODS: A language concordant AEF was conducted at a Latino community center. LEP caregivers of children 1-12 years old and an established asthma diagnosis participated in three skill stations: (a) medication recognition and administration, (b) peak flow use (if child ≥ 5 years) and (c) action plan dissemination. Spacers, peak flow meters and individualized action plans were distributed. A validated, pediatric asthma caregiver quality of life questionnaire (PACQLQ-Spanish version) was administered. Baseline data was compared to follow-up interview data at three and six months after the AEF. Mean PACQLQ scores were analyzed with Wilcoxon signed-rank test and nominal paired data with McNemar's test. RESULTS: We analyzed data from 18 caregivers able to speak English well (22%), not well (28%) or not at all (50%). After three months, improved caregiver QoL was experienced (51 vs. 72, p<0.01). No differences were observed in medication recognition, spacer and peak flow use or peak flow interpretation. After six months, mean school days missed due to asthma decreased (4.1 vs. 0.4, p<0.01). Mean clinic visits, emergency department visits and hospitalizations remained unchanged. CONCLUSIONS: Implementation of a community-based AEF with action plan administration can be beneficial for LEP caregivers and their children. QoL improvements to emotional wellbeing and activity limitations were observed, and lower rates of school absenteeism were reported. Caregiver ability to accurately identify medications was not enhanced.


Assuntos
Asma , Cuidadores/estatística & dados numéricos , Educação em Saúde , Hispânico ou Latino , Absenteísmo , Adolescente , Corticosteroides/uso terapêutico , Agonistas Adrenérgicos beta/uso terapêutico , Adulto , Instituições de Assistência Ambulatorial/estatística & dados numéricos , Antiasmáticos/uso terapêutico , Asma/tratamento farmacológico , Asma/etnologia , Cuidadores/psicologia , Criança , Pré-Escolar , Pesquisa Participativa Baseada na Comunidade , Serviço Hospitalar de Emergência/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Hospitalização/estatística & dados numéricos , Humanos , Lactente , Idioma , Inaladores Dosimetrados , Pessoa de Meia-Idade , Qualidade de Vida , Características de Residência , Adulto Jovem
14.
J Int Acad Periodontol ; 17(4): 116-22, 2015 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-26727150

RESUMO

AIM: The aim of this study was to correlate radiographic examination with the clinical periodontal condition in cases of biologic width invasion by overextending restoration margins in restored premolars and molars. MATERIALS AND METHODS: The present pilot study involved nine people (mean age 32 years) with biologic width invasion by 21 surfaces overextending restoration margins in restored premolars and molars. Radiographs were made in a standardized unit using the interproximal technique and were evaluated by a single calibrated investigator. The clinical periodontal parameters were analyzed with the use of a computerized periodontal probe. Exploratory analysis and Spearman's correlation were used to perform statistical analyses (SPSS, p < 0.05). RESULTS: The most prevalent teeth with biologic width invasion were second premolars and first molars. Mean plaque index was 30.76%, and bleeding on probing was 27.0%. The mesial surface was invaded in 47.6% of cases and the distal surface in 52.4%. The 21 sites with biologic width invasion were found in patients with the following periodontal status: periodontal health (11 sites), gingivitis (2 sites), mild periodontitis (7 sites) and moderate periodontitis (1 site). There was a correlation between plaque index and bleeding on probing with the horizontal component of the bone level. CONCLUSIONS: There was correlation between the radiographic parameters of biologic width invasion and clinical conditions. The measure of the bone crest level correlated with the gingival recession. The horizontal component of bone defect correlated with plaque index and bleeding on probing.


Assuntos
Dente Pré-Molar/patologia , Restauração Dentária Permanente/efeitos adversos , Dente Molar/patologia , Doenças Periodontais/etiologia , Periodonto/patologia , Adulto , Perda do Osso Alveolar/diagnóstico por imagem , Perda do Osso Alveolar/etiologia , Processo Alveolar/diagnóstico por imagem , Índice de Placa Dentária , Feminino , Gengiva/patologia , Retração Gengival/diagnóstico por imagem , Retração Gengival/etiologia , Gengivite/diagnóstico por imagem , Gengivite/etiologia , Humanos , Queratinas , Masculino , Perda da Inserção Periodontal/diagnóstico por imagem , Perda da Inserção Periodontal/etiologia , Doenças Periodontais/diagnóstico por imagem , Índice Periodontal , Periodontite/diagnóstico por imagem , Periodontite/etiologia , Projetos Piloto , Radiografia , Propriedades de Superfície
15.
Sex Med ; 12(4): qfae050, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39224134

RESUMO

Background: Previous studies have provided initial evidence supporting the association between compulsive sexual behavior (CSB) and alexithymia, but these studies did not investigate the psychometric property of a measure of alexithymia in individuals with CSB, which is necessary. Aim: This study investigated the factor analysis, reliability, and construct validity of the Toronto Alexithymia Scale (TAS) in men with CSB and control individuals. Methods: This cross-sectional study included 418 participants (304 individuals with CSB and 114 control individuals) who underwent a semi-structured psychiatric interview and completed the following instruments: the Sexual Compulsivity Scale, Hypersexual Disorder Screening Inventory, Beck Anxiety Inventory, Beck Depression Inventory, TAS, and Barratt Impulsiveness Scale. The eligible participants were men 18 years of age or older who were literate and residing in Brazil. Individuals who met the diagnostic criteria for Goodman's criteria for sex addiction were subsequently assessed for the excessive sexual drive (International Classification of Diseases-Tenth Revision F52.7) criteria. Those who met this second criteria were considered individuals with CSB. Participants who did not reach this point were considered control individuals. We conducted factor analysis, reliability analysis (internal consistency and temporal stability), and discriminant and construct validity analyses. Outcomes: The outcomes included the TAS total score and scores on TAS factors 1, 2, 3, and 4. Results: The extracted factors explained 44% of the variance in the TAS. Factor 1 explained 21%, but 3 items (items 2, 9, and 21) did not load onto this factor. The Cronbach's alpha was 0.83, and the reproducibility (intraclass correlation coefficient) was 0.70. The TAS can differentiate between individuals with CSB and control individuals. The different forms of validity were demonstrated through correlations between factors 1 to 4 and the total score, as well as with impulsivity, hypersexuality, sexual compulsivity, and depression. Surprisingly, anxiety was only weakly correlated with factors 1 and 2. Moreover, the TAS-4 score was not correlated with impulsivity. Clinical Implications: The TAS can be used in clinical practice to identify men with difficulties in recognizing subjective experiences, and proper interventions can subsequently be provided to these patients to increase their treatment efficacy. Strengths and Limitations: Various dimensions of alexithymia covary with other key psychopathological symptoms of CSB. This study examined a convenience sample. The results cannot be generalized to the broader population. Factors 3 and 4 presented low internal consistency (0.50). Conclusion: In general, TAS presented good psychometric properties in a sample mainly composed of individuals with CSB.

16.
Stud Health Technol Inform ; 315: 87-91, 2024 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-39049231

RESUMO

EHR Interoperability is crucial to obtain a set of benefits. This can be achieved by using data standards, like ontologies. The Portuguese Nursing Ontology (NursingOntos) is a reference model describing a set of nursing concepts and their relationships, to represent nursing knowledge in the Electronic Health Records (EHR). The purpose of this work was to define a set of correspondences between Nursing Ontology concepts of NursingOntos and other terminologies, which have the same or similar meaning. In this project, we are using the ISO/TR12300:2016 standard on the principles of mapping between terminological systems. Regarding the domain of "airway clearance", we can say that Portuguese Nursing Ontology has a good level of mapping with other terminologies. In conclusion, we can say that Portuguese Nursing Ontology can be used in EHR with the purpose of a global digitalization of health.


Assuntos
Registros Eletrônicos de Saúde , Terminologia Padronizada em Enfermagem , Systematized Nomenclature of Medicine , Portugal , Registros de Enfermagem , Processamento de Linguagem Natural , Vocabulário Controlado , Humanos
17.
Mol Biol Rep ; 40(8): 4883-7, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23649769

RESUMO

The close relationship between aflatoxins and 249ser TP53 gene mutation (AGG to AGT, Arg to Ser) in hepatocellular carcinoma (HCC) makes this mutation an indirect indicator of dietary contamination with this toxin. We have examined the prevalence of codon 249 TP53 mutation in 41 HCC and 74 liver cirrhosis (without HCC) cases diagnosed at the HUCAM University Hospital in Vitoria, Espírito Santo State, Brazil. DNA was extracted from paraffin sections and from plasma. The mutation was detected by DNA amplification, followed by restriction endonuclease digestion and confirmed by direct sequencing. DNA restriction showed 249ser mutation in 16 HCC and 13 liver cirrhosis, but sequencing confirmed mutations in only 6 HCC and 1 liver cirrhosis. In addition, sequencing revealed 4 patients with mutations at codon 250 (250ser and 250leu) in HCC cases. The prevalence of TP53 mutation was 10/41 (24.3%) in HCC and 1/74 (1.4%) in liver cirrhosis. No relationship between the presence of mutations and the etiology of HCC was observed. TP53 exon 7 mutations, which are related to aflatoxins exposure, were found at 14.6% (249ser), 7.3% (250leu) and 2.4% (250ser) in 41 cases of HCC and 1.4% in 74 liver cirrhosis (without HCC) cases, suggesting a moderate dietary exposure to aflatoxins in the Espírito Santo State, Brazil.


Assuntos
Aflatoxinas/toxicidade , Carcinoma Hepatocelular/genética , Cirrose Hepática/genética , Neoplasias Hepáticas/genética , Proteína Supressora de Tumor p53/genética , Sequência de Bases , Brasil , Primers do DNA/genética , Contaminação de Alimentos , Humanos , Dados de Sequência Molecular , Mutação de Sentido Incorreto/genética , Polimorfismo de Fragmento de Restrição , Análise de Sequência de DNA
18.
Artigo em Inglês | MEDLINE | ID: mdl-37442332

RESUMO

Co-use of marijuana and tobacco products is the second most common drug combination among adolescents. Nicotine (NIC) and cannabinoid use during adolescence induce similar detrimental changes, raising the hypothesis that simultaneous exposure could result in even more severe outcomes. Thus, we investigated whether the co-exposure to NIC and the synthetic cannabinoid WIN 55,212-2 (WIN) in adolescent mice causes behavioral outcomes different from those observed after exposure to a single drug. Male Swiss mice were exposed twice daily to NIC, WIN, or NIC + WIN during adolescence (PND28-47) or adulthood (PND70-89). Drug combination led to a greater reduction in weight gain in adolescent mice, while NIC-induced weight loss was observed in adults. During administration, NIC provoked hypothermia, and WIN produced hyperlocomotion in adolescent and adult mice. Animals exposed to NIC + WIN presented a profile of changes similar to those exposed to NIC. After drug exposure, changes in locomotion, thigmotaxis, social preference, prepulse inhibition, and working and recognition memory were evaluated. Adolescent but not adult mice exposed to NIC showed withdrawal-related hyperlocomotion unaffected by WIN co-administration. An age-specific impairment in object recognition memory was induced only by drug co-exposure during adolescence, which resolved spontaneously before reaching early adulthood. A transient decrease in hippocampal α7 nAChR subunit and CB1 receptor mRNA levels was induced by NIC exposure, which may be involved but is not enough to explain the memory impairment. Our work confirms the potential of NIC and cannabinoids association to aggravate some of the individual drug effects during critical neurodevelopmental periods.


Assuntos
Canabinoides , Nicotina , Camundongos , Masculino , Animais , Nicotina/farmacologia , Transtornos da Memória , Canabinoides/farmacologia , Reconhecimento Psicológico , Combinação de Medicamentos , Benzoxazinas/farmacologia
19.
Artigo em Inglês | MEDLINE | ID: mdl-36361136

RESUMO

Work is fundamental to an individual's mental health; however, an unfavourable work environment can lead to mental health problems. Despite existing studies addressing workers' mental health, it is essential to understand the reality of specific contexts to design effective tailored interventions. Thus, this study aimed to examine the influence of potential protective and vulnerability factors on municipal workers' depressive symptoms, anxiety and stress levels, and burnout. A cross-sectional study was conducted with data collection performed between July and December 2021 using online self-report measures. The sample comprised 115 municipal workers. The findings revealed that psychological vulnerability is a significant vulnerability factor for the presence of mental health symptoms. In addition, job satisfaction was found to be a significant protective factor for depressive symptoms, anxiety, and burnout of the municipal workers. The results of this study enhance the understanding of factors that influence worker mental health, which may facilitate the proper planning of specific interventions to promote mental health in the workplace.


Assuntos
Esgotamento Profissional , Saúde Ocupacional , Humanos , Saúde Mental , Estudos Transversais , Local de Trabalho/psicologia , Esgotamento Profissional/psicologia
20.
Artigo em Inglês | MEDLINE | ID: mdl-35742278

RESUMO

The term 'mental health literacy' was first introduced in 1997, and it was defined as 'knowledge and beliefs about mental disorders which aid their recognition, management or prevention' [...].


Assuntos
Letramento em Saúde , Transtornos Mentais , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Transtornos Mentais/psicologia , Transtornos Mentais/terapia , Saúde Mental
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