Detalhe da pesquisa
1.
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.
Immunity
; 44(3): 609-621, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944201
2.
A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.
Nature
; 562(7727): 429-433, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297801
3.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638506
4.
Translational pharmacokinetic/pharmacodynamic analysis in cancer pharmacology: a tool to maximize the value of antitumor efficacy from tumor bearing mice.
Drug Discov Today Technol
; 21-22: 51-56, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27978988
5.
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg Med Chem Lett
; 24(18): 4546-4552, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139565
6.
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Bioorg Med Chem Lett
; 24(12): 2635-9, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24813737
7.
A paracrine requirement for hedgehog signalling in cancer.
Nature
; 455(7211): 406-10, 2008 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18754008
8.
Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist.
Drug Metab Dispos
; 41(12): 2104-13, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24041744
9.
Combined PD-L1/TGFß blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Nat Commun
; 14(1): 4703, 2023 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37543621
10.
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
N Engl J Med
; 361(12): 1173-8, 2009 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19726761
11.
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.
J Biol Chem
; 284(50): 34553-60, 2009 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854829
12.
Generalized Additive Mixed Modeling of Longitudinal Tumor Growth Reduces Bias and Improves Decision Making in Translational Oncology.
Cancer Res
; 80(22): 5089-5097, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32978171
13.
Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge.
J Immunother Cancer
; 8(2)2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32675310
14.
GDC-0449-a potent inhibitor of the hedgehog pathway.
Bioorg Med Chem Lett
; 19(19): 5576-81, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19716296
15.
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.
Sci Signal
; 11(547)2018 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206136
16.
IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition.
Cell Death Dis
; 13(9): 831, 2022 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36171193
17.
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
ACS Med Chem Lett
; 7(4): 351-6, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096040
18.
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
J Med Chem
; 59(12): 5650-60, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27227380
19.
Translational value of mouse models in oncology drug development.
Nat Med
; 21(5): 431-9, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25951530
20.
Prediction of drug distribution in subcutaneous xenografts of human tumor cell lines and healthy tissues in mouse: application of the tissue composition-based model to antineoplastic drugs.
J Pharm Sci
; 104(4): 1508-21, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25615572