Detalhe da pesquisa
1.
High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo.
J Biol Chem
; 300(2): 105618, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38176652
2.
Variations of the Mycobacterium abscessus F-ATP synthase subunit a-c interface alter binding and potency of the anti-TB drug bedaquiline.
Biochem Biophys Res Commun
; 690: 149249, 2024 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38000294
3.
Atomic insights of an up and down conformation of the Acinetobacter baumannii F1 -ATPase subunit ε and deciphering the residues critical for ATP hydrolysis inhibition and ATP synthesis.
FASEB J
; 37(7): e23040, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37318822
4.
Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc Natl Acad Sci U S A
; 118(11)2021 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33729990
5.
Cryo-Electron Microscopy Structure of the Mycobacterium tuberculosis Cytochrome bcc:aa3 Supercomplex and a Novel Inhibitor Targeting Subunit Cytochrome cI.
Antimicrob Agents Chemother
; 67(6): e0153122, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37158740
6.
Cryo-EM structure of the Mycobacterium abscessus F1-ATPase.
Biochem Biophys Res Commun
; 671: 140-145, 2023 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37302287
7.
Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1.
Antimicrob Agents Chemother
; 66(5): e0001822, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35481752
8.
Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors.
Antimicrob Agents Chemother
; 66(12): e0105622, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36445139
9.
Frozen and freeze-dried solvent/detergent treated plasma: Two different pharmaceutical formulations with comparable quality.
Transfusion
; 62(12): 2621-2630, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36181447
10.
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
Bioorg Med Chem
; 74: 117046, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36228522
11.
Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase.
Mol Divers
; 25(1): 517-524, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31939065
12.
The Unique C-Terminal Extension of Mycobacterial F-ATP Synthase Subunit α Is the Major Contributor to Its Latent ATP Hydrolysis Activity.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32988828
13.
TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31712198
14.
3D reconstruction and flexibility of the hybrid engine Acetobacterium woodii F-ATP synthase.
Biochem Biophys Res Commun
; 527(2): 518-524, 2020 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32423799
15.
Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase.
Biochem Biophys Res Commun
; 522(2): 374-380, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31761325
16.
Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.
Proc Natl Acad Sci U S A
; 114(28): 7426-7431, 2017 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28652330
17.
Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines.
Angew Chem Int Ed Engl
; 59(32): 13295-13304, 2020 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32337801
18.
Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ.
J Struct Biol
; 207(2): 199-208, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31132404
19.
TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358589
20.
Structural model of a2-subunit N-terminus and its binding interface for Arf-GEF CTH2: Implication for regulation of V-ATPase, CTH2 function and rational drug design.
Curr Top Membr
; 83: 77-106, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31196611