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The impact of micro-level people's activities on urban macro-level indicators is a complex question that has been the subject of much interest among researchers and policymakers. Transportation preferences, consumption habits, communication patterns and other individual-level activities can significantly impact large-scale urban characteristics, such as the potential for innovation generation of the city. Conversely, large-scale urban characteristics can also constrain and determine the activities of their inhabitants. Therefore, understanding the interdependence and mutual reinforcement between micro- and macro-level factors is critical to defining effective public policies. The increasing availability of digital data sources, such as social media and mobile phones, has opened up new opportunities for the quantitative study of this interdependency. This paper aims to detect meaningful city clusters on the basis of a detailed analysis of the spatiotemporal activity patterns for each city. The study is carried out on a worldwide city dataset of spatiotemporal activity patterns obtained from geotagged social media data. Clustering features are obtained from unsupervised topic analyses of activity patterns. Our study compares state-of-the-art clustering models, selecting the model achieving a 2.7% greater Silhouette Score than the next-best model. Three well-separated city clusters are identified. Additionally, the study of the distribution of the City Innovation Index over these three city clusters shows discrimination of low performing from high performing cities relative to innovation. Low performing cities are identified in one well-separated cluster. Therefore, it is possible to correlate micro-scale individual-level activities to large-scale urban characteristics.
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Meios de Transporte , Humanos , Cidades , Análise por Conglomerados , Fatores de TempoRESUMO
INTRODUCTION: Despite multiple prognostic indicators described for oral cavity squamous cell carcinoma (OCSCC), its management still continues to be a matter of debate. Machine learning is a subset of artificial intelligence that enables computers to learn from historical data, gather insights, and make predictions about new data using the model learned. Therefore, it can be a potential tool in the field of head and neck cancer. METHODS: We conducted a systematic review. RESULTS: A total of 81 manuscripts were revised, and 46 studies met the inclusion criteria. Of these, 38 were excluded for the following reasons: use of a classical statistical method (N = 16), nonspecific for OCSCC (N = 15), and not being related to OCSCC survival (N = 7). In total, 8 studies were included in the final analysis. CONCLUSIONS: ML has the potential to significantly advance research in the field of OCSCC. Advantages are related to the use and training of ML models because of their capability to continue training continuously when more data become available. Future ML research will allow us to improve and democratize the application of algorithms to improve the prediction of cancer prognosis and its management worldwide.
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Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Neoplasias Bucais , Algoritmos , Inteligência Artificial , Carcinoma de Células Escamosas/terapia , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Aprendizado de Máquina , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/terapia , Prognóstico , Carcinoma de Células Escamosas de Cabeça e Pescoço/terapiaRESUMO
This paper presents an automatic system for the quality control of metallic components using a photometric stereo-based sensor and a customized semantic segmentation network. This system is designed based on interoperable modules, and allows capturing the knowledge of the operators to apply it later in automatic defect detection. A salient contribution is the compact representation of the surface information achieved by combining photometric stereo images into a RGB image that is fed to a convolutional segmentation network trained for surface defect detection. We demonstrate the advantage of this compact surface imaging representation over the use of each photometric imaging source of information in isolation. An empirical analysis of the performance of the segmentation network on imaging samples of materials with diverse surface reflectance properties is carried out, achieving Dice performance index values above 0.83 in all cases. The results support the potential of photometric stereo in conjunction with our semantic segmentation network.
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BACKGROUND: Despite the increasing use of intraoperative facial nerve monitoring during parotid gland surgery (PGS) and the improvement in the preoperative radiological assessment, facial nerve injury (FNI) remains the most severe complication after PGS. Until now, no studies have been published regarding the application of machine learning (ML) for predicting FNI after PGS. We hypothesize that ML would improve the prediction of patients at risk. METHODS: Patients who underwent PGS for benign tumors between June 2010 and June 2019 were included. RESULTS: Regarding prediction accuracy and performance of each ML algorithm, the K-nearest neighbor and the random forest achieved the highest sensitivity, specificity, positive predictive value, negative predictive value F-score, receiver operating characteristic (ROC)-area under the ROC curve, and accuracy globally. The K-nearest neighbor algorithm achieved performance values above 0.9 for specificity, negative predictive value, F-score and ROC-area under the ROC curve, and the highest sensitivity and positive predictive value. CONCLUSIONS: This study demonstrates that ML prediction models can provide evidence-based predictions about the risk of FNI to otolaryngologists and patients. It is hoped that such algorithms, which use clinical, radiological, histological, and cytological information, can improve the information given to patients before surgery so that they can be better informed of any potential complications.
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Traumatismos do Nervo Facial/etiologia , Paralisia Facial/etiologia , Aprendizado de Máquina , Glândula Parótida/cirurgia , Neoplasias Parotídeas/cirurgia , Complicações Pós-Operatórias/etiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto JovemRESUMO
The wide availability of satellite data from many distributors in different domains of science has provided the opportunity for the development of new and improved methodologies to aid the analysis of environmental problems and to support more reliable estimations and forecasts. Moreover, the rapid development of specialized technologies in satellite instruments provides the opportunity to obtain a wide spectrum of various measurements. The purpose of this research is to use publicly available remote sensing product data computed from geostationary, polar and near-polar satellites and radar to improve space-time modeling and prediction of precipitation on Crete island in Greece. The proposed space-time kriging method carries out the fusion of remote sensing data with data from ground stations that monitor precipitation during the hydrological period 2009/10-2017/18. Precipitation observations are useful for water resources, flood and drought management studies. However, monitoring stations are usually sparse in regions with complex terrain, are clustered in valleys, and often have missing data. Satellite precipitation data are an attractive alternative to observations. The fusion of the datasets in terms of the space-time residual kriging method exploits the auxiliary satellite information and aids in the accurate and reliable estimation of precipitation rates at ungauged locations. In addition, it represents an alternative option for the improved modeling of precipitation variations in space and time. The obtained results were compared with the outcomes of similar works in the study area.
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Surface flatness assessment is necessary for quality control of metal sheets manufactured from steel coils by roll leveling and cutting. Mechanical-contact-based flatness sensors are being replaced by modern laser-based optical sensors that deliver accurate and dense reconstruction of metal sheet surfaces for flatness index computation. However, the surface range images captured by these optical sensors are corrupted by very specific kinds of noise due to vibrations caused by mechanical processes like degreasing, cleaning, polishing, shearing, and transporting roll systems. Therefore, high-quality flatness optical measurement systems strongly depend on the quality of image denoising methods applied to extract the true surface height image. This paper presents a deep learning architecture for removing these specific kinds of noise from the range images obtained by a laser based range sensor installed in a rolling and shearing line, in order to allow accurate flatness measurements from the clean range images. The proposed convolutional blind residual denoising network (CBRDNet) is composed of a noise estimation module and a noise removal module implemented by specific adaptation of semantic convolutional neural networks. The CBRDNet is validated on both synthetic and real noisy range image data that exhibit the most critical kinds of noise that arise throughout the metal sheet production process. Real data were obtained from a single laser line triangulation flatness sensor installed in a roll leveling and cut to length line. Computational experiments over both synthetic and real datasets clearly demonstrate that CBRDNet achieves superior performance in comparison to traditional 1D and 2D filtering methods, and state-of-the-art CNN-based denoising techniques. The experimental validation results show a reduction in error than can be up to 15% relative to solutions based on traditional 1D and 2D filtering methods and between 10% and 3% relative to the other deep learning denoising architectures recently reported in the literature.
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The global population is aging in an unprecedented manner and the challenges for improving the lives of older adults are currently both a strong priority in the political and healthcare arena. In this sense, preventive measures and telemedicine have the potential to play an important role in improving the number of healthy years older adults may experience and virtual coaching is a promising research area to support this process. This paper presents COLAEVA, an interactive web application for older adult population clustering and evolution analysis. Its objective is to support caregivers in the design, validation and refinement of coaching plans adapted to specific population groups. COLAEVA enables coaching caregivers to interactively group similar older adults based on preliminary assessment data, using AI features, and to evaluate the influence of coaching plans once the final assessment is carried out for a baseline comparison. To evaluate COLAEVA, a usability test was carried out with 9 test participants obtaining an average SUS score of 71.1. Moreover, COLAEVA is available online to use and explore.
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Tutoria , Telemedicina , Idoso , Mineração de Dados , Humanos , Internet , Grupos PopulacionaisRESUMO
Flatness sensors are required for quality control of metal sheets obtained from steel coils by roller leveling and cutting systems. This article presents an innovative system for real-time robust surface estimation of flattened metal sheets composed of two line lasers and a conventional 2D camera. Laser plane triangulation is used for surface height retrieval along virtual surface fibers. The dual laser allows instantaneous robust and quick estimation of the fiber height derivatives. Hermite cubic interpolation along the fibers allows real-time surface estimation and high frequency noise removal. Noise sources are the vibrations induced in the sheet by its movements during the process and some mechanical events, such as cutting into separate pieces. The system is validated on synthetic surfaces that simulate the most critical noise sources and on real data obtained from the installation of the sensor in an actual steel mill. In the comparison with conventional filtering methods, we achieve at least a 41% of improvement in the accuracy of the surface reconstruction.
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Computational intelligence is a very active and fruitful research of artificial intelligence with a broad spectrum of applications. Remote sensing data has been a salient field of application of computational intelligence algorithms, both for the exploitation of the data and for the research/development of new data analysis tools. In this editorial paper we provide the setting of the special issue "Computational Intelligence in Remote Sensing" and an overview of the published papers. The 11 accepted and published papers cover a wide spectrum of applications and computational tools that we try to summarize and put in perspective in this editorial paper.
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Indoor crowd localization and counting in big public buildings pose problems of infrastructure deployment, signal processing, and privacy. Conventional approaches based on optical cameras, either in the visible or infrared range, received signal strength in wireless networks, sound or chemical sensing in sensor networks need careful calibration, noise removal, and sophisticated data processing to achieve results in limited scenarios. Moreover, personal data protection is a growing concern, so that detection methods that preserve the privacy of people are highly desirable. The aim of this paper is to provide a technique that may generate estimations of the localization of people in a big public building using anonymous data from already-deployed Wi-Fi infrastructure. We present a method applying geostatistical techniques to the access data acquired from Access Points (AP) in an open Wi-Fi network. Specifically, only the time series of the number of accesses per AP is required. Geostatistical methods produce a 3D high-quality spatial distribution representation of the people inside the building based on the interaction of their mobile devices with the APs. We report encouraging results obtained from data acquired at a building of Wroclaw University of Science and Technology.
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Resting-state studies conducted with stroke patients are scarce. The study of brain activity and connectivity at rest provides a unique opportunity for the investigation of brain rewiring after stroke and plasticity changes. This study sought to identify dynamic changes in the functional organization of the default mode network (DMN) of stroke patients at three months after stroke. Eleven patients (eight male and three female; age range: 48-72) with right cortical and subcortical ischemic infarctions and 17 controls (eleven males and six females; age range: 57-69) were assessed by neurological and neuropsychological examinations and scanned with resting-state functional magnetic ressonance imaging. First, we explored group differences in functional activity within the DMN by means of probabilistic independent component analysis followed by a dual regression approach. Second, we estimated functional connectivity between 11 DMN nodes both locally by means of seed-based connectivity analysis, as well as globally by means of graph-computation analysis. We found that patients had greater DMN activity in the left precuneus and the left anterior cingulate gyrus when compared with healthy controls (P < 0.05 family-wise error corrected). Seed-based connectivity analysis showed that stroke patients had significant impairment (P = 0.014; threshold = 2.00) in the connectivity between the following five DMN nodes: left superior frontal gyrus (lSFG) and posterior cingulate cortex (t = 2.01); left parahippocampal gyrus and right superior frontal gyrus (t = 2.11); left parahippocampal gyrus and lSFG (t = 2.39); right parietal and lSFG (t = 2.29). Finally, mean path length obtained from graph-computation analysis showed positive correlations with semantic fluency test (r(s) = 0.454; P = 0.023), phonetic fluency test (r(s) = 0.523; P = 0.007) and the mini mental state examination (r(s) = 0.528; P = 0.007). In conclusion, the ability to regulate activity of the DMN appears to be a central part of normal brain function in stroke patients. Our study expands the understanding of the changes occurring in the brain after stroke providing a new avenue for investigating lesion-induced network plasticity.
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Isquemia Encefálica/fisiopatologia , Isquemia Encefálica/psicologia , Encéfalo/fisiopatologia , Acidente Vascular Cerebral/fisiopatologia , Acidente Vascular Cerebral/psicologia , Adulto , Idoso , Mapeamento Encefálico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Vias Neurais/fisiopatologia , Testes Neuropsicológicos , Descanso , Processamento de Sinais Assistido por ComputadorRESUMO
BACKGROUND: Disease trajectories have become increasingly relevant within the context of an aging population and the rising prevalence of chronic illnesses. Understanding the temporal progression of diseases is crucial for enhancing patient care, preventive measures, and effective management. OBJECTIVE: The objective of this study is to propose and validate a novel methodology for trajectory impact analysis and interactive visualization of disease trajectories over a cohort of 71,849 patients. METHODS: This article introduces an innovative comprehensive approach for analysis and interactive visualization of disease trajectories. First, Risk Increase (RI) index is defined that assesses the impact of the initial disease diagnosis on the development of subsequent illnesses. Secondly, visual graphics methods are used to represent cohort trajectories, ensuring a clear and semantically rich presentation that facilitates easy data interpretation. RESULTS: The proposed approach is demonstrated over the disease trajectories of a cohort comprising 71,849 patients from Tolosaldea, Spain. The study finds several clinically relevant trajectories in this cohort, such as that after suffering a cerebral ischemic stroke, the probability of suffering dementia increases 10.77 times. The clinical relevance of the study outcomes have been assessed by an in-depth analysis conducted by expert clinicians. The identified disease trajectories are in agreement with the latest advancements in the field. CONCLUSION: The proposed approach for trajectory impact analysis and interactive visualization offers valuable graphs for the comprehensive study of disease trajectories for improved clinical decision-making. The simplicity and interpretability of our methods make them valuable approach for healthcare professionals.
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Progressão da Doença , Humanos , Estudos de Coortes , Feminino , Masculino , Idoso , Espanha/epidemiologia , Pessoa de Meia-Idade , Idoso de 80 Anos ou maisRESUMO
Mycorrhizal inoculation of conifer roots is a key strategy to optimize establishment and performance of forest tree species under both natural and cultivated conditions and also to mitigate transplantation shock. However, despite being a common practice, inoculation in outdoor nursery conditions has been poorly studied. Here, we have evaluated effectiveness of four fungal species (Lactarius deliciosus, Lactarius quieticolor, Pisolithus arhizus, and Suillus luteus) in the production of mycorrhizal Pinus pinaster seedlings in an outdoor commercial nursery and their ability to improve seedling physiology and field performance. All inoculated seedlings showed a significant increase in growth at the end of the nursery stage and these differences remained after 3 years of growth in the field. Differences observed in the content of malondialdehyde, total chlorophyll, carotenoids, anthocyanins, and phenolic compounds from needles of mycorrhizal and control seedlings may reflect a different sensitivity to photo-oxidative damage. We conclude that ectomycorrhizal inoculation improves adaptability to changeable growing conditions of an outdoor nursery and produces a higher quality nursery stock, thereby enhancing seedling performance after planting.
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Basidiomycota/fisiologia , Micorrizas/fisiologia , Pinus/crescimento & desenvolvimento , Pinus/microbiologia , Plântula/crescimento & desenvolvimento , Plântula/microbiologia , Simbiose , Adaptação Fisiológica , Compostos Orgânicos/análise , Pinus/química , Pinus/fisiologia , Desenvolvimento Vegetal , Plântula/química , Plântula/fisiologiaRESUMO
Cardiovascular diseases are the leading cause of death globally, taking an estimated 17.9 million lives each year. Heart failure (HF) occurs when the heart is not able to pump enough blood to satisfy metabolic needs. People diagnosed with chronic HF may suffer from cardiac decompensation events (CDEs), which cause patients' worsening. Being able to intervene before decompensation occurs is the major challenge addressed in this study. The aim of this study is to exploit available patient data to develop an artificial intelligence (AI) model capable of predicting the risk of CDEs timely and accurately. Materials and Methods: The vital variables of patients (n = 488) diagnosed with chronic heart failure were monitored between 2014 and 2022. Several supervised classification models were trained with these monitoring data to predict CDEs, using clinicians' annotations as the gold standard. Feature extraction methods were applied to identify significant variables. Results: The XGBoost classifier achieved an AUC of 0.72 in the cross-validation process and 0.69 in the testing set. The most predictive physiological variables for CAE decompensations are weight gain, oxygen saturation in the final days, and heart rate. Additionally, the answers to questionnaires on wellbeing, orthopnoea, and ankles are strongly significant predictors.
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BACKGROUND: Frailty is characterized by a progressive decline in the physiological functions of multiple body systems that lead to a more vulnerable condition, which is prone to the development of various adverse events, such as falls, hospitalization, and mortality. This study aims to determine whether frailty increases mortality compared to pre-frailty and to identify variables associated with a higher risk of mortality. MATERIALS: Two cohorts, frail and pre-frail subjects, are evaluated according to the Fried phenotype. A complete examination of frailty, cognitive status, comorbidities and pharmacology was carried out at hospital admission and was extracted through electronic health record (EHR). Mortality was evaluated from the EHR. METHODS: Kaplan-Meier estimates of survival probability functions were calculated at two years censoring time for frail and pre-frail cohorts. The log-rank test assessed significant differences between survival probability functions. Significant variables for frailty (p < 0-05) were extracted by independent sample t-test. Further selection was based on variable significance found in multivariate logistic regression discrimination between frail and pre-frail subjects. Cox regression over univariate t-test-selected variables was calculated to identify variables associated with higher proportional hazard risks (HR) at two years. RESULTS: Frailty is associated with greater mortality at two years censoring time than pre-frailty (log-rank test, p < 0.0001). Variables with significant (p < 0.05) association with mortality identified in both cohorts (HR 95% (CI in the frail cohort) are male sex (0.44 (0.29-0.66)), age (1.05 (1.01-1.09)), weight (0.98 (0.96-1.00)), and use of proton-pump inhibitors (PPIs) (0.60 (0.41-0.87)). Specific high-risk factors in the frail cohort are readmission at 30 days (0.50 (0.33-0.74)), SPPB sit and stand (0.62 (0.45-0.85)), heart failure (0.67 (0.46-0.98)), use of antiplatelets (1.80 (1.19-2.71)), and quetiapine (0.31 (0.12-0.81)). Specific high-risk factors in the pre-frail cohort are Barthel's score (120 (7.7-1700)), Pfeiffer test (8.4; (2.3-31)), Mini Nutritional Assessment (MNA) (1200 (18-88,000)), constipation (0.025 (0.0027-0.24)), falls (18,000 (150-2,200,000)), deep venous thrombosis (8400 (19-3,700,000)), cerebrovascular disease (0.01 (0.00064-0.16)), diabetes (360 (3.4-39,000)), thyroid disease (0.00099 (0.000012-0.085)), and the use of PPIs (0.062 (0.0072-0.54)), Zolpidem (0.000014 (0.0000000021-0.092)), antidiabetics (0.00015 (0.00000042-0.051)), diuretics (0.0003 (0.000004-0.022)), and opiates (0.000069 (0.00000035-0.013)). CONCLUSIONS: Frailty is associated with higher mortality at two years than pre-frailty. Frailty is recognized as a systemic syndrome with many links to older-age comorbidities, which are also found in our study. Polypharmacy is strongly associated with frailty, and several commonly prescribed drugs are strongly associated with increased mortality. It must be considered that frail patients need coordinated attention where the diverse specialist taking care of them jointly examines the interactions between the diversity of treatments prescribed.
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In this article, we highlight an issue that arises when using multiple b-values in a model-based analysis of diffusion MR data for tractography. The non-monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in the distribution of fiber orientations when not considered in the model. Extra fiber orientations perpendicular to the main orientation arise to compensate for the slower apparent signal decay at higher b-values. We propose a simple extension to the ball and stick model based on a continuous gamma distribution of diffusivities, which significantly improves the fitting and reduces the overfitting. Using in vivo experimental data, we show that this model outperforms a simpler, noise floor model, especially at the interfaces between brain tissues, suggesting that partial volume effects are a major cause of the observed non-monoexponential decay. This model may be helpful for future data acquisition strategies that may attempt to combine multiple shells to improve estimates of fiber orientations in white matter and near the cortex.
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Algoritmos , Encéfalo/citologia , Imagem de Tensor de Difusão/métodos , Interpretação de Imagem Assistida por Computador/métodos , Fibras Nervosas Mielinizadas/ultraestrutura , Reconhecimento Automatizado de Padrão/métodos , Técnica de Subtração , Simulação por Computador , Humanos , Aumento da Imagem/métodos , Modelos Anatômicos , Modelos Neurológicos , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
In recent years, speech emotion recognition (SER) has emerged as one of the most active human-machine interaction research areas. Innovative electronic devices, services and applications are increasingly aiming to check the user emotional state either to issue alerts under some predefined conditions or to adapt the system responses to the user emotions. Voice expression is a very rich and noninvasive source of information for emotion assessment. This paper presents a novel SER approach based on that is a hybrid of a time-distributed convolutional neural network (TD-CNN) and a long short-term memory (LSTM) network. Mel-frequency log-power spectrograms (MFLPSs) extracted from audio recordings are parsed by a sliding window that selects the input for the TD-CNN. The TD-CNN transforms the input image data into a sequence of high-level features that are feed to the LSTM, which carries out the overall signal interpretation. In order to reduce overfitting, the MFLPS representation allows innovative image data augmentation techniques that have no immediate equivalent on the original audio signal. Validation of the proposed hybrid architecture achieves an average recognition accuracy of 73.98% on the most widely and hardest publicly distributed database for SER benchmarking. A permutation test confirms that this result is significantly different from random classification ([Formula: see text]). The proposed architecture outperforms state-of-the-art deep learning models as well as conventional machine learning techniques evaluated on the same database trying to identify the same number of emotions.
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Emoções , Fala , Humanos , Aprendizado de Máquina , Redes Neurais de Computação , PercepçãoRESUMO
Understanding at microscopic level the generation of contents in an online social network (OSN) is highly desirable for an improved management of the OSN and the prevention of undesirable phenomena, such as online harassment. Content generation, i.e., the decision to post a contributed content in the OSN, can be modeled by neurophysiological approaches on the basis of unbiased semantic analysis of the contents already published in the OSN. This paper proposes a neuro-semantic model composed of (1) an extended leaky competing accumulator (ELCA) as the neural architecture implementing the user concurrent decision process to generate content in a conversation thread of a virtual community of practice, and (2) a semantic modeling based on the topic analysis carried out by a latent Dirichlet allocation (LDA) of both users and conversation threads. We use the similarity between the user and thread semantic representations to built up the model of the interest of the user in the thread contents as the stimulus to contribute content in the thread. The semantic interest of users in discussion threads are the external inputs for the ELCA, i.e., the external value assigned to each choice.. We demonstrate the approach on a dataset extracted from a real life web forum devoted to fans of tinkering with musical instruments and related devices. The neuro-semantic model achieves high performance predicting the content posting decisions (average F score 0.61) improving greatly over well known machine learning approaches, namely random forest and support vector machines (average F scores 0.19 and 0.21).
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This study aims to determine when frailty increases the risks of delirium mortality. Hospital patients falling into the elderly frail or pre-frail category were recruited, some without delirium, some with delirium at admission, and some who developed delirium during admission. We screened for frailty, cognitive status, and co-morbidities whenever possible and extracted drug information and mortality data from electronic health records. Kaplan-Meier estimates of survival probability functions were computed at four times, comparing delirium versus non delirium patients. Differences in survival were assessed by a log-rank test. Independent Cox's regression was carried out to identify significant hazard risks (HR) at 1 month, 6 months, 1 year, and 2 years. Delirium predicted mortality (log-rank test, p < 0.0001) at all four censoring points. Variables with significant HRs were frailty indicators, comorbidities, polypharmacy, and the use of specific drugs. For the delirium cohort, variables with the most significant 2-year hazard risks (HR(95%CI)) were: male gender (0.43 20 (0.26,0.69)), weight loss (0.45 (0.26,0.74)), sit and stand up test (0.67 (0.49,0.92)), readmission within 30 days of discharge (0.50 (0.30,0.80)), cerebrovascular disease (0.45 (0.27,0.76)), head trauma (0.54 22 (0.29,0.98)), number of prescribed drugs (1.10 (1.03,1.18)), and the use of diuretics (0.57 (0.34,0.96)). These results suggest that polypharmacy and the use of diuretics increase mortality in frail elderly patients with delirium.