Detalhe da pesquisa
1.
Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging.
Circ Res
; 130(2): 252-272, 2022 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34930019
2.
A recombinant signalling-selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models.
Wound Repair Regen
; 32(1): 90-103, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38155595
3.
Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
Int J Mol Sci
; 25(2)2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279255
4.
Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation.
J Biol Chem
; 298(2): 101567, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35007530
5.
Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect.
Blood
; 137(24): 3428-3442, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33534910
6.
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently.
Circ Res
; 128(4): 513-529, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33353373
7.
3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1ß, and Inflammatory Cell Accumulation in the Retina.
Int J Mol Sci
; 24(13)2023 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37445820
8.
An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure.
J Transl Med
; 20(1): 199, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35538547
9.
Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus.
Blood
; 135(22): 1969-1982, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32276277
10.
3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation.
Int J Mol Sci
; 23(22)2022 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430674
11.
Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells.
Blood
; 134(9): 776-781, 2019 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243040
12.
Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis.
Blood
; 134(14): 1119-1131, 2019 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31434703
13.
FVIIa (Factor VIIa) Induces Biased Cytoprotective Signaling in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 (Arginine41) Site.
Arterioscler Thromb Vasc Biol
; 40(5): 1275-1288, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32212848
14.
Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo.
Arterioscler Thromb Vasc Biol
; 40(4): 901-913, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32102568
15.
Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombin activation.
J Biol Chem
; 294(41): 15176-15181, 2019 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31481465
16.
3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase.
Stroke
; 51(7): 2236-2239, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32568648
17.
Novel exomic rare variants associated with venous thrombosis.
Br J Haematol
; 190(5): 783-786, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32232851
18.
Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke.
Ann Neurol
; 85(1): 125-136, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30450637
19.
Activated protein C, protease activated receptor 1, and neuroprotection.
Blood
; 132(2): 159-169, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866816
20.
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.
Blood
; 131(11): 1163-1171, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343482