Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Human T_H17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.

Chao, Ying-Yin; Puhach, Alisa; Frieser, David; Arunkumar, Mahima; Lehner, Laurens; Seeholzer, Thomas; Garcia-Lopez, Albert; van der Wal, Marlot; Fibi-Smetana, Silvia; Dietschmann, Axel; Sommermann, Thomas; Cikovic, Tamara; Taher, Leila; Gresnigt, Mark S; Vastert, Sebastiaan J; van Wijk, Femke; Panagiotou, Gianni; Krappmann, Daniel; Groß, Olaf; Zielinski, Christina E.

Nat Immunol ; 24(2): 295-308, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36604548

2.

Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.

Roth, Stefan; Cao, Jiayu; Singh, Vikramjeet; Tiedt, Steffen; Hundeshagen, Gabriel; Li, Ting; Boehme, Julia D; Chauhan, Dhruv; Zhu, Jie; Ricci, Alessio; Gorka, Oliver; Asare, Yaw; Yang, Jun; Lopez, Mary S; Rehberg, Markus; Bruder, Dunja; Zhang, Shengxiang; Groß, Olaf; Dichgans, Martin; Hornung, Veit; Liesz, Arthur.

Immunity ; 54(4): 648-659.e8, 2021 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-33667383

3.

ß-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner.

Eisenbeis, Verena B; Qiu, Danye; Gorka, Oliver; Strotmann, Lisa; Liu, Guizhen; Prucker, Isabel; Su, Xue Bessie; Wilson, Miranda S C; Ritter, Kevin; Loenarz, Christoph; Groß, Olaf; Saiardi, Adolfo; Jessen, Henning J.

Proc Natl Acad Sci U S A ; 120(34): e2306868120, 2023 08 22.

Artigo em Inglês | MEDLINE | ID: mdl-37579180

4.

STAT3 signaling induced by the IL-6 family of cytokines modulates angiogenesis.

Rapp, Julian; Jung, Malte; Klar, Rhena F U; Wolf, Julian; Arnold, Jakob; Gorka, Oliver; Groß, Olaf; Lange, Clemens; Agostini, Hansjürgen; Schlunck, Günther; Bucher, Felicitas.

J Cell Sci ; 136(1)2023 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-36458801

5.

PKA Has the Gall to Oppose NLRP3.

Groß, Christina J; Groß, Olaf.

Immunity ; 45(4): 707-709, 2016 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-27760332

6.

K⁺ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Groß, Christina J; Mishra, Ritu; Schneider, Katharina S; Médard, Guillaume; Wettmarshausen, Jennifer; Dittlein, Daniela C; Shi, Hexin; Gorka, Oliver; Koenig, Paul-Albert; Fromm, Stephan; Magnani, Giovanni; Cikovic, Tamara; Hartjes, Lara; Smollich, Joachim; Robertson, Avril A B; Cooper, Matthew A; Schmidt-Supprian, Marc; Schuster, Michael; Schroder, Kate; Broz, Petr; Traidl-Hoffmann, Claudia; Beutler, Bruce; Kuster, Bernhard; Ruland, Jürgen; Schneider, Sabine; Perocchi, Fabiana; Groß, Olaf.

Immunity ; 45(4): 761-773, 2016 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-27692612

7.

Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8⁺ T cells.

Winkler, Frances; Hipp, Anna V; Ramirez, Carlos; Martin, Bianca; Villa, Matteo; Neuwirt, Emilia; Gorka, Oliver; Aerssens, Jeroen; Johansson, Susanne E; Rana, Nisha; Llewellyn-Lacey, Sian; Price, David A; Panning, Marcus; Groß, Olaf; Pearce, Erika L; Hermann, Carl M; Schumann, Kathrin; Hannibal, Luciana; Neumann-Haefelin, Christoph; Boettler, Tobias; Knolle, Percy; Hofmann, Maike; Wohlleber, Dirk; Thimme, Robert; Bengsch, Bertram.

Gut ; 72(10): 1971-1984, 2023 10.

Artigo em Inglês | MEDLINE | ID: mdl-37541771

8.

Paradoxical immunodeficiencies-When failures of innate immunity cause immunopathology.

Kolter, Julia; Henneke, Philipp; Groß, Olaf; Kierdorf, Katrin; Prinz, Marco; Graf, Laura; Schwemmle, Martin.

Eur J Immunol ; 52(9): 1419-1430, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35551651

9.

Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.

Neumann, Konstantin; Castiñeiras-Vilariño, Mercedes; Höckendorf, Ulrike; Hannesschläger, Nicole; Lemeer, Simone; Kupka, Danny; Meyermann, Svenia; Lech, Maciej; Anders, Hans-Joachim; Kuster, Bernhard; Busch, Dirk H; Gewies, Andreas; Naumann, Ronald; Groß, Olaf; Ruland, Jürgen.

Immunity ; 40(3): 389-99, 2014 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-24631154

10.

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Poeck, Hendrik; Bscheider, Michael; Gross, Olaf; Finger, Katrin; Roth, Susanne; Rebsamen, Manuele; Hannesschläger, Nicole; Schlee, Martin; Rothenfusser, Simon; Barchet, Winfried; Kato, Hiroki; Akira, Shizuo; Inoue, Satoshi; Endres, Stefan; Peschel, Christian; Hartmann, Gunther; Hornung, Veit; Ruland, Jürgen.

Nat Immunol ; 11(1): 63-9, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19915568

11.

Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36.

Smolka, Christian; Schlösser, Delia; Koentges, Christoph; Tarkhnishvili, Aleksandre; Gorka, Oliver; Pfeifer, Dietmar; Bemtgen, Xavier; Asmussen, Alexander; Groß, Olaf; Diehl, Philipp; Moser, Martin; Bode, Christoph; Bugger, Heiko; Grundmann, Sebastian; Pankratz, Franziska.

FASEB J ; 35(11): e21956, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34605573

12.

Chemoproteomics-Enabled Identification of 4-Oxo-ß-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.

Carvalho, Luís A R; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M; Podlesainski, David; Vieira, Andreia C; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D; Groß, Olaf; Geiss-Friedlander, Ruth; Cravatt, Benjamin F; Huber, Robert; Kaiser, Markus; Moreira, Rui.

Angew Chem Int Ed Engl ; 61(47): e202210498, 2022 11 21.

Artigo em Inglês | MEDLINE | ID: mdl-36089535

13.

Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

Gross, Olaf; Yazdi, Amir S; Thomas, Christina J; Masin, Mark; Heinz, Leonhard X; Guarda, Greta; Quadroni, Manfredo; Drexler, Stefan K; Tschopp, Jurg.

Immunity ; 36(3): 388-400, 2012 Mar 23.

Artigo em Inglês | MEDLINE | ID: mdl-22444631

14.

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

Vince, James E; Wong, W Wei-Lynn; Gentle, Ian; Lawlor, Kate E; Allam, Ramanjaneyulu; O'Reilly, Lorraine; Mason, Kylie; Gross, Olaf; Ma, Stephen; Guarda, Greta; Anderton, Holly; Castillo, Rosa; Häcker, Georg; Silke, John; Tschopp, Jürg.

Immunity ; 36(2): 215-27, 2012 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-22365665

15.

Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T_H17-deviated acute contact dermatitis in human subjects.

Garzorz-Stark, Natalie; Lauffer, Felix; Krause, Linda; Thomas, Jenny; Atenhan, Anne; Franz, Regina; Roenneberg, Sophie; Boehner, Alexander; Jargosch, Manja; Batra, Richa; Mueller, Nikola S; Haak, Stefan; Groß, Christina; Groß, Olaf; Traidl-Hoffmann, Claudia; Theis, Fabian J; Schmidt-Weber, Carsten B; Biedermann, Tilo; Eyerich, Stefanie; Eyerich, Kilian.

J Allergy Clin Immunol ; 141(4): 1320-1333.e11, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-28935206

16.

The Nlrp3 inflammasome admits defeat.

Groß, Christina J; Groß, Olaf.

Trends Immunol ; 36(6): 323-4, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25991463

17.

Walking over the inflammasome.

Gorka, Oliver; Neuwirt, Emilia; Groß, Olaf.

Nat Chem Biol ; 15(6): 552-553, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31086328

18.

Helicobacter pylori-induced IL-1ß secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island.

Semper, Raphaela P; Mejías-Luque, Raquel; Groß, Christina; Anderl, Florian; Müller, Anne; Vieth, Michael; Busch, Dirk H; Prazeres da Costa, Clarissa; Ruland, Jürgen; Groß, Olaf; Gerhard, Markus.

J Immunol ; 193(7): 3566-76, 2014 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-25172489

19.

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.

Shahzad, Khurrum; Bock, Fabian; Dong, Wei; Wang, Hongjie; Kopf, Stefan; Kohli, Shrey; Al-Dabet, Moh'd Mohanad; Ranjan, Satish; Wolter, Juliane; Wacker, Christian; Biemann, Ronald; Stoyanov, Stoyan; Reymann, Klaus; Söderkvist, Peter; Groß, Olaf; Schwenger, Vedat; Pahernik, Sascha; Nawroth, Peter P; Gröne, Herman-Josef; Madhusudhan, Thati; Isermann, Berend.

Kidney Int ; 87(1): 74-84, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25075770

20.

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.

Lehle, Anna S; Farin, Henner F; Marquardt, Benjamin; Michels, Birgitta E; Magg, Thomas; Li, Yue; Liu, Yanshan; Ghalandary, Maryam; Lammens, Katja; Hollizeck, Sebastian; Rohlfs, Meino; Hauck, Fabian; Conca, Raffaele; Walz, Christoph; Weiss, Batia; Lev, Atar; Simon, Amos J; Groß, Olaf; Gaidt, Moritz M; Hornung, Veit; Clevers, Hans; Yazbeck, Nadine; Hanna-Wakim, Rima; Shouval, Dror S; Warner, Neil; Somech, Raz; Muise, Aleixo M; Snapper, Scott B; Bufler, Philip; Koletzko, Sibylle; Klein, Christoph; Kotlarz, Daniel.

Gastroenterology ; 156(1): 275-278, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30267714

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