Knowledge mapping of extracellular vesicles in wound healing: A bibliometric analysis (2002-2022).

Extracellular vesicles in wound healing have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualise the research hot spots and trends of extracellular vesicles in wound healing using a bibliometric analysis to help understand the future development of basic and clinical research. The articles and reviews regarding extracellular vesicles in the wound healing were selected from the Web of Science Core Collection. VOSviewers, CiteSpace and R package "bibliometric" were used to conduct this bibliometric analysis. A total of 1225 articles from 56 countries led by China and the United States were included. The number of publications related to extracellular vesicles increased year by year. Shanghai Jiaotong University, Huazhong University of Science and Technology, Sun Yat-sen University and Central South University are the main research institutions. International Journal of Molecular Sciences is the most popular journal in this field, while Stem Cell Research & Therapy is the most frequently cited journal. These papers come from 7546 authors, among which Zhang Wei has published the most papers and Zhang Bin has the most cocited papers. The research on the treatment strategy of extracellular vesicles in the process of wound healing is the main topic in this field. "exosomes", "miRNA", "angiogenesis", "regenerative medicine", "inflammation" and "diabetic wound" are the main key words of emerging research hotspots. This is the first bibliometric study, which comprehensively summarises the research trend and development of extracellular vesicles and exocrine bodies in wound healing. These informations determine the latest research frontiers and hot directions, and provide reference for the study of extracellular vesicles and exosomes.

Comparison of Vacuum Sealing Drainage and Traditional Therapy for Treatment of Diabetic Foot Ulcers: A Meta-Analysis.

Vacuum sealing drainage (VSD) is a noninvasive adjunctive therapy to help patients with diabetic foot ulcers by reducing edema and promoting wound healing and formation of granulation tissue. Multiple databases were searched for relevant studies, and full-text articles comparing VSD and conventional therapy were reviewed. Meta-analyses were conducted with Review Manager 5.0 software to estimate the results of the selected articles. Forest plots, sensitivity analysis, and bias analysis were also performed on the included articles. In total, 10 studies satisfied the inclusion criteria and were selected in this study. The meta-analysis suggested that the duration of therapy, decrease of wound size, and efficacy rate showed statistically significant differences between the 2 groups (mean difference = -12.86; 95% confidence interval [CI] -12.86 to -8.52; p < .00001; mean difference = 8.71; 95% CI 3.25 to 14.17; p = .002; relative risk = 1.41; 95% CI 1.22 to 1.62; p < .00001, respectively) although the complication rate between the 2 groups was comparable (relative risk = 0.83; 95% CI 0.60 to 1.16; p = .28). Publication bias was not assessed because only a few articles were included. In conclusion, VSD is a more effective therapy and is associated with a greater decrease in wound size and shorter time to wound healing, compared to the conventional method.

Comparison of endovenous laser treatment and high ligation in treatment of limb varicosity: A meta-analysis.

To assess the efficacy and safety of endovenous laser treatment (EVLT) and high ligation (HL) for limb varicosity using meta-analysis. Multiple databases including PubMed, Springer, Excerpta Medica Database, Ovid Technologies, and China Journal Full-text database were searched for relevant studies in English or Chinese, and full-text articles were used to compare EVLT and HL for limb varicosity. Review Manager 5.0 was used to estimate the effects of the results among eligible articles. Forest plots, sensitivity analysis, and bias analysis of the included articles were also conducted. Initial screening yielded 1031 studies, 11 randomised controlled trials involving 1145 limb varicosity patients met the inclusion criteria in this study. The results of the heterogeneity test suggested that intraoperative blood loss mean difference (MD) = -6.31[-9.03, -3.60], P < 0.00001), operative time (MD) = -39.76[-42.27, -37.24], P < 0.00001), rate of complications (odds ratio [OR] = 0.37[0.22, 0.61], P < 0.0001), and recurrence (OR = 0.28[0.16, 0.49], P < 0.0001) were significantly different. Although both EVLT and HL have their own merits and demerits, EVLT is a more effective and safe method to treat limb varicosity.