Detalhe da pesquisa
1.
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Bioorg Med Chem
; 24(5): 938-956, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852340
2.
Development of synthetic methodology suitable for the radiosynthesis of combretastatin A-1 (CA1) and its corresponding prodrug CA1P.
J Nat Prod
; 72(3): 414-21, 2009 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19161336
3.
Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups.
J Med Chem
; 51(11): 3069-72, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18457380
4.
Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity.
J Med Chem
; 50(9): 2259-63, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17408248
5.
Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.
J Med Chem
; 49(11): 3204-14, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16722638
6.
Guanine binding of a cytotoxic platinum-acridin-9-ylthiourea conjugate monitored by 1-D 1H and 2-D [1H,15N] NMR spectroscopy: hydrolysis is not the rate-determining step.
J Inorg Biochem
; 100(5-6): 972-9, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16488016
7.
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
J Nat Prod
; 71(3): 313-20, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18303849
8.
Adenine-N3 in the DNA minor groove - an emerging target for platinum containing anticancer pharmacophores.
Anticancer Agents Med Chem
; 7(1): 125-38, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17266509