Silver nanowires/cellulose flexible transparent conductive films for electromagnetic interference shielding and electrothermal conversion.

Currently, electromagnetic shielding materials need to meet the characteristics of lightweight, high transmittance, and robust conductivity. Silver nanowires (AgNWs) have progressively found applications in recent years owing to their excellent aspect ratio, conductivity, and flexibility. The properties of AgNWs vary with different aspect ratios, and the length and diameter of AgNWs often exert diverse influences on the photoelectric properties of conductive films. In this study, we combined AgNWs with hydroxypropyl methylcellulose (HPMC) and employed a directional stacking arrangement method to apply AgNWs onto the PET substrate, investigating the properties of four distinct aspect ratios of AgNWs (1000, 750, 625, and 531). Ultimately, the prepared four films achieved electromagnetic shielding capabilities ranging from 26.6 dB to 32.8 dB, with a transmittance range of 89.8% to 94.6%, showing excellent electromagnetic shielding properties. Moreover, the prepared films showed an exceedingly low roughness value (RMS = 7.07 nm), remarkable flexibility, and superior oxidation resistance with the facilitation of HPMC. The films also showed exceptional electrothermal conversion prowess, achieving saturation temperature within a mere 8 seconds, thereby displaying a rapid thermal response. Furthermore, when a voltage of 4 V was applied, the temperature of the thin film remained essentially constant for a duration of 2500 seconds, highlighting its admirable thermal stability, which is of great significance for the development of flexible and transparent electromagnetic shielding materials in the future.

Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights.

Hypoxic injury is a critical pathological factor in the development of various cardiovascular diseases, such as congenital heart disease, myocardial infarction, and heart failure. Mitochondrial quality control is essential for protecting cardiomyocytes from hypoxic damage. Under hypoxic conditions, disruptions in mitochondrial homeostasis result in excessive reactive oxygen species (ROS) production, imbalances in mitochondrial dynamics, and initiate pathological processes including oxidative stress, inflammatory responses, and apoptosis. Targeted interventions to enhance mitochondrial quality control, such as coenzyme Q10 and statins, have shown promise in mitigating hypoxia-induced mitochondrial dysfunction. These treatments offer potential therapeutic strategies for hypoxia-related cardiovascular diseases by regulating mitochondrial fission and fusion, restoring mitochondrial biogenesis, reducing ROS production, and promoting mitophagy.

Multilayer directionally arranged silver nanowire networks for flexible transparent conductive films.

Silver nanowire (AgNW) networks have excellent optoelectronic properties and have important applications in various optoelectronic devices. However, the random distribution of AgNWs coated on the substrate will cause problems such as uneven resistance and high surface roughness, which will affect the properties of the film. In order to solve these problems, this paper adopts the method of directional arrangement of AgNWs to prepare conductive films, by mixing AgNW aqueous solution with hydroxypropyl methyl cellulose (HPMC) to prepare conductive ink, and then the AgNWs are oriented on the flexible substrate by using the shear force generated during the Mayer rod coating process. The multilayer crossed three-dimensional (3D) AgNW conductive network is prepared, achieving a sheet resistance of 12.9 Ω sq-1 and a transmittance of 92.2% (λ = 550 nm). In addition, the roughness RMS value of the layered and ordered AgNW/HPMC composite film is only 6.96 nm, which is much lower than that of the randomly arranged AgNW film (RMS = 19.8 nm), and the composite film also has excellent bending resistance and environmental stability. This adjustable coating method is simple to prepare and can realize the large-scale manufacturing of conductive films, which is important for the future development of flexible transparent conductive films.

Enhanced bioaccumulation efficiency and tolerance for Cd (â ¡) in Arabidopsis thaliana by amphoteric nitrogen-doped carbon dots.

Amphoteric nitrogen-doped carbon dots (N-CDs) that prepared environmentally friendly have rich functional groups, such as carboxyl, amino, hydroxyl, carbonyl, etc. Through electrostatic attraction and complexation between the chemical groups and metal ions, N-CDs present excellent adsorption capacity for Cd2+ in heavy polluted water with the saturated adsorption weight of 559  mg g-1. The investigation of interaction between N-CDs, Cd2+ and Arabidopsis thaliana reveals that N-CDs (from 4  mg kg-1 to 8  mg kg-1) can dramatically enhance Cd bioaccumulation of plants by 58.3% of unit biomass and 260% of individual seedling when the plants were cultivated for 10 days under Cd stress (from 10 mg kg-1 to 50 mg kg-1). Simultaneously, N-CDs significantly alleviate the toxicity caused by high Cd stress on Arabidopsis thaliana seedlings growth. N-CDs induce higher germination rate (maximum: 2.5-fold), higher biomass (maximum: 3.7-fold), better root development (maximum: 1.4-fold), higher photosynthetic efficiency and higher antioxidant capacity in plants under Cd stress. When the Cd and N-CDs concentration are respective 20 mg kg-1 and 4 mg kg-1, the enzyme activities of the catalase and peroxidase increased to 2.73-fold and 1.45-fold, respectively. This research prove the potential application of amphoteric N-CDs in phytoremediation because N-CDs greatly mitigate the growth retardation of plant caused by Cd2+ even with the extremely increased Cd2+ concentration in vivo.

Impacts of surface chemistry of functional carbon nanodots on the plant growth.

Functional carbon nanodots (FCNs) with multiple chemical groups have great impact on the growth regulation of plants. To understand the role of the chemical groups, FCNs were reduced from the raw material by pyrolysis method and hydrolysis method. The chemical structure of these materials were characterized by using TGA, TEM, FT-IR, XPS, Raman and elementary analysis. The raw and reduced FCNs were used as plants growth regulators in culture medium of Arabidopsis thaliana. Our results indicate there is a strong correlation between the physiological responses of plants and the surface chemistries (especially carboxyl group and ester group) of the nanomaterials. The quantum-sized FCNs with multiple carboxyl groups and ester groups show better aqueous dispersity and can induce various positive physiological responses in Arabidopsis thaliana seedlings compared with the FCNs decorated without carboxyl and ester as well as aggregated FCNs. The raw FCNs present higher promotion capacity in plants biomass and roots length, and the quantum-sized FCNs are easier to be absorbed by plants and generate more positive effects on plants.

Exploring the Mechanism of Ferroptosis Induction by Sappanone A in Cancer: Insights into the Mitochondrial Dysfunction Mediated by NRF2/xCT/GPX4 Axis.

Non-small cell lung cancer (NSCLC), a major subtype of lung cancer, encompasses squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Compared to small cell lung cancer, NSCLC cells grow and divide more slowly, and their metastasis occurs at a later stage. Currently, chemotherapy is the primary treatment for this disease. Sappanone A (SA) is a flavonoid compound extracted from the plant Caesalpinia sappan, known for its antitumor, redox-regulating, and anti-inflammatory properties. Recent studies have investigated the interaction of SA with mitochondrial pathways in regulating cell death through the Nrf-2/GPX-4/xCT axis. This study specifically explores the mechanism by which SA affects mitochondrial morphology and structure through the regulation of mitophagy and mitochondrial biogenesis in tumor cells. The study primarily utilizes second-generation transcriptomic sequencing data and molecular docking techniques to elucidate the role of SA in regulating programmed cell death in tumor cells. The omics results indicate that SA treatment significantly targets genes involved in oxidative phosphorylation, mitophagy, mitochondrial dynamics, and oxidative stress. Further findings confirmed that the Nrf-2/GPX4/xCT pathway serves as a crucial target of SA in the treatment of NSCLC. Knockdown of Nrf-2 (si-Nrf-2) and Nrf-2 overexpression (ad-Nrf-2) were shown to modulate the therapeutic efficacy of SA to varying degrees. Additionally, modifications to the GPX4/xCT genes significantly affected the regulatory effects of SA on mitochondrial autophagy, biogenesis, and energy metabolism. These regulatory mechanisms may be mediated through the caspase pathway and ferroptosis-related signaling. Molecular biology experiments have demonstrated that SA intervention further inhibits the phosphorylation of FUNDC1 at Tyr18 and downregulates TOM20 expression. SA treatment was found to reduce the expression of PGC1α, Nrf-1, and Tfam, resulting in a decrease in mitochondrial respiration and energy metabolism. Overexpression of Nrf-2 was shown to counteract the regulatory effects of SA on mitophagy and mitochondrial biogenesis. Confocal microscopy experiments further revealed that SA treatment increases mitochondrial fragmentation, subsequently inducing mitochondrial pathway-mediated programmed cell death. However, genetic modification of the Nrf-2/GPX4/xCT pathway significantly altered the regulatory effects of SA on tumor cells. In conclusion, SA has been identified as a promising therapeutic agent for NSCLC. The mitochondrial pathway-mediated apoptosis and ferroptosis may represent key mechanisms in regulating tumor cell death. Targeting the Nrf-2/GPX-4/xCT axis offers a novel therapeutic approach for maintaining mitochondrial homeostasis within the cellular microenvironment.

Ecotoxicological evaluation of functional carbon nanodots using zebrafish (Danio rerio) model at different developmental stages.

Considering functional carbon nanodots (FCNs) are potential to be applied in many areas, their risk and toxicity to organisms are imperative to be evaluated. Thus, this study conducted acute toxicity test of zebrafish (Danio rerio) at embryonic and adult stage to estimate the toxicity of FCNs. Results show that the toxic effects of FCNs and nitrogen doped FCNs (N-FCNs) at their 10% lethal concentration (LC10) values on zebrafish are expressed in developmental retardation, cardiovascular toxicity, renal damage and hepatotoxicity. There are interactive relationships between these effects, but the main reason should be ascribed to the undesirable oxidative damage induced by high doses of materials, as well as the biodistribution of FCNs and N-FCNs in vivo. Even so, FCNs and N-FCNs can promote the antioxidant activity in zebrafish tissues to cope with the oxidative stress. FCNs and N-FCNs are not easy to cross the physical barriers in zebrafish embryos or larvae, and can be excreted from intestine by adult fish, which proves their biosecurity to zebrafish. In addition, because of the differences in physicochemical properties, especially nano-size and surface chemical property, FCNs show higher biosecurity to zebrafish than N-FCNs. The effects of FCNs and N-FCNs on hatching rates, mortality rates and developmental malformations are dose-dependent and time-dependent. The LC50 values of FCNs and N-FCNs on zebrafish embryo at 96 hpf are 1610 mg/L and 649 mg/L, respectively. According to the Acute Toxicity Rating Scale of the Fish and Wildlife Service, the toxicity grades of FCNs and N-FCNs are both defined as "practically nontoxic", and FCNs are "Relatively Harmless" to embryos because their LC50 values are above 1000 mg/L. Our results prove the biosecurity of FCNs-based materials for future practical application.

3D Numerical Simulation and Structural Optimization for a MEMS Skin Friction Sensor in Hypersonic Flow.

The skin friction of a hypersonic vehicle surface can account for up to 50% of the total resistance, directly affecting the vehicle's effective range and load. A wind tunnel experiment is an important and effective method to optimize the aerodynamic shape of aircraft, and Micro-Electromechanical System (MEMS) skin friction sensors are considered the promising sensors in hypersonic wind tunnel experiments, owing to their miniature size, high sensitivity, and stability. However, the sensitive structure including structural appearance, a gap with the package shell, and flatness of the sensor will change the measured flow field and cause the accurate measurement of friction resistance. Aiming at the influence of sensor-sensitive structure on wall-flow characteristics and friction measurement accuracy, the two-dimensional and three-dimensional numerical models of the sensor in the hypersonic flow field based on Computational Fluid Dynamics (CFD) are presented respectively in this work. The model of the sensor is verified by using the Blathius solution of two-dimensional laminar flow on a flat plate. The results show that the sensor model is in good agreement with the Blathius solution, and the error is less than 0.4%. Then, the influence rules of the sensitive structure of the sensor on friction measurement accuracy under turbulent flow and laminar flow conditions are systematically analyzed using 3D numerical models of the sensor, respectively. Finally, the sensor-sensitive unit structure's design criterion is obtained to improve skin friction's measurement accuracy.

MEMS Skin Friction Sensor with High Response Frequency and Large Measurement Range.

Micro-electromechanical system (MEMS) skin friction sensors are considered to be promising sensors in hypersonic wind tunnel experiments owing to their miniature size, high sensitivity, and stability. Aiming at the problem of short test duration (a few milliseconds) and heavy load in a shock wind tunnel, the fast readout circuit and the sensor head structures of a MEMS skin friction sensor are presented and optimized in this work. The sensor was fabricated using various micro-mechanical processes and micro-assembly technology based on visual alignment. Meanwhile, the sensor head structure was integrated with the fast readout circuit and tested by using a centrifugal force equivalent method. The calibration results show that this sensor provides good linearity, sensitivity, and stability. The measurement ranges are 0-2000 Pa with good performance. The resolution is better than 10 Pa at 3000 Hz detection frequency of the readout circuit for the sensor in ranges from 0 to 1000 Pa. In addition, the repeatability and linearity of static calibration for sensors are better than 1%.

Functional carbon nanodots improve soil quality and tomato tolerance in saline-alkali soils.

High salinity and alkalinity of saline-alkali soil lead to soil deterioration, the subsequent osmotic stress and ion toxicity inhibited crops growth and productivity. In this research, 8 mg kg-1 and 16 mg kg-1 functional carbon nanodots (FCNs) can alleviate the adverse effects of saline-alkali on tomato plant at both seedling and harvest stages, thanks to their up-regulation effects on soil properties and plant physiological processes. On one hand, FCNs stimulate the plant potential of tolerance to saline-alkali and disease resistance through triggering the defense response of antioxidant system, enhancing the osmotic adjustment, promoting the nutrient uptake, transportation and utilization, and up-regulating the photosynthesis, thereby improve tomato growth and productivity in saline-alkali soils. On the other hand, FCNs application contributes to the improvement of soil physicochemical properties and fertilities, as well as decline soil salinity and alkalinity, which are related to plant growth and fruit quality. This research also focuses on the dose-dependent effects of FCNs on their regulation effects and toxicity to tomato growth under stress or non-stress. These findings recommend that FCNs could be applied as potential amendments to ameliorate the saline-alkali soil and improve the tomato tolerance and productivity in the Yellow River Delta.

A highly sensitive ppb-level H2S gas sensor based on fluorophenoxy-substituted phthalocyanine cobalt/rGO hybrids at room temperature.

The peripheral and non-peripheral substitution of 4-trifluoromethylphenoxy groups in the design of gas sensing phthalocyanine cobalt/reduced graphene oxide (rGO) hybrids with two different positions of the substituents was realized. Tetra-α(ß)-(4-trifluoromethylphenoxy)phthalocyanine cobalt/reduced graphene oxide (3(4)-cF3poPcCo/rGO) hybrids were prepared through noncovalent interaction, and were analyzed by FT-IR, UV-vis, TGA and SEM. The gas sensing performance of the cF3poPcCo/rGO hybrid gas sensors towards ppb hydrogen sulfide (H2S) was measured at room temperature. The results show that the 4-cF3poPcCo/rGO sensor has better sensitivity, selectivity and reproducibility than the 3-cF3poPcCo/rGO sensor, as well as a perfect linear response to the concentration of H2S. For the 4-cF3poPcCo/rGO sensor, the response sensitivity to 1 ppm H2S is as high as 46.58, the response and recovery times are 600 s and 50 s for 1 ppm H2S, and the detection limit is as low as 11.6 ppb. This is mainly due to the loose and porous structure of the cF3poPcCo/rGO hybrids, the fact that graphene is an excellent conductive agent, and the fact that the electron-withdrawing capability of the trifluoromethyl group can increase the holes of rGO and PcCo. In addition, through electrochemical impedance spectroscopy (EIS) and I-V curves, and density functional theory, the influence of different positions of the substituents of cF3poPcCo/rGO on the sensing performance and the sensing mechanism for improving sensitivity were discussed and confirmed in detail.

A high-sensitive room temperature gas sensor based on cobalt phthalocyanines and reduced graphene oxide nanohybrids for the ppb-levels of ammonia detection.

Highly sensitive gas sensing materials are of great importance for environmental pollution monitoring. In this study, four nanohybrid materials containing different phenoxyl substituents of cobalt phthalocyanines (tetra-ß-carboxylphenoxylphthalocyanine cobalt (cpoPcCo), tetra-ß-(4-carboxy-3-methoxyphenoxy)phthalocyanine cobalt (cmpoPcCo), tetra-ß-phenoxylphthalocyanine cobalt (poPcCo), and tetra-ß-(3-methoxyphenoxy)phthalocyanine cobalt (mpoPcCo)) and reduced graphene oxide (rGO) (RPcCo/rGO) were synthesized via non-covalent interactions as a high performance gas sensing materials for the ppb-level detection of ammonia (NH3). Various characterization techniques, including FT-IR, Raman, UV-vis, TGA, XPS and SEM, were used to confirm the structure, element information and morphology of the as-synthesized materials. The obtained materials were used in interdigital electrodes to fabricate the sensing device, and the gas sensing performance was investigated at room temperature. The obtained sensors exhibited excellent sensitivity, selectivity, good reproducibility and perfect response-concentration linearity towards NH3, which are mainly ascribed to the synergetic effects of RPcCo and rGO due to the specific surface area structure for NH3 diffusion, the abundant active sites to adsorb NH3, and excellent conductivity for efficient electron transport, particularly the effect of RPcCo. For example, the cpoPcCo/rGO-based sensor showed a higher and faster response for low concentration of NH3 (∼2.5 and 45 s for 100 ppb of NH3), a ppb level detection and superior stability over 60 days. Besides, the effect of different phenoxyl substituents of cobalt phthalocyanines on the sensing performance and the sensing mechanism for the sensitivity enhancement were discussed and confirmed by the first-principles density functional theory calculations and electrochemical impedance spectroscopy (EIS).

Spectroscopic approach for the interaction of carbon nanoparticles with cytochrome c and BY-2 cells: Protein structure and mitochondrial function.

In this study, we employed multiple spectroscopic methods to analyze the effects of carbon nanoparticles (CNPs) on structure of cytochrome c (Cyt c) and mitochondrial function in plant cells. The tertiary structures of aromatic amino acid in Cyt c were not changed after addition of CNPs. Cyt c was found to be absorbed on the surfaces of CNPs in a non-linear manner and only bound Cyt c can be reduced. In addition, the binding of Cyt c was found to increase the diameter of CNPs at lower concentrations. The redox potential of Cyt c was almost not affected after treatment with CNPs. There were no obvious differences in cellular ATP after exposure to CNPs, and the mitochondrial membrane potential (MMP) was significantly decreased once the CNPs concentration exceeded 31.25 µg/mL. The levels of reactive oxygen species (ROS) also were increased in BY-2 cells. Taken together, these findings provide basis for the interactions between CNPs and Cyt c, as well as the effect of CNPs treatment on the mitochondria function in plant cells.

The effects of amino substituents on the enhanced ammonia sensing performance of PcCo/rGO hybrids.

Three reversible ammonia (NH3) gas sensors were fabricated using tetra-α-(p-aminobenzyloxy)phthalocyanine cobalt (ABOPcCo), tetra-α-aminophthalocyanine cobalt (APcCo) and substituent-free phthalocyanine cobalt (FPcCo) functionalized reduced graphene oxide (rGO), with cost-efficient, highly sensitive and stable sensing performance. These hybrid materials were prepared via a facile physical solution mixing self-assembly reaction with rGO and PcCo solutions. The obtained PcCo/rGO hybrid sensors exhibit excellent sensing performance; especially the ABOPcCo/rGO sensor, whose response is about 23.3% (50 ppm), with a limit of detection as low as 78 ppb, and response and recovery times about as fast as 225 s and 250 s. The performance of the PcCo/rGO hybrid sensors can be optimized by adjusting the concentrations of the PcCo/rGO aqueous dispersions. More importantly, the NH3-sensing performance of the PcCo/rGO sensors was tuned by adjusting the substituent structure of PcCo. The enhanced NH3-sensing performance may be attributed to synergistic effects between PcCo and rGO, e.g., stronger adsorption interactions between PcCo with an aminophenoxy substituent and NH3, the high electrical conductivity of rGO, and fast charge transfer between PcCo and rGO. These are further confirmed via first-principle density functional theory (DFT) calculations and electrochemical impedance spectra (EIS) measurements.