Age and Gender Impact on Heart Rate Variability towards Noninvasive Glucose Measurement.

Heart rate variability (HRV) parameters can reveal the performance of the autonomic nervous system and possibly estimate the type of its malfunction, such as that of detecting the blood glucose level. Therefore, we aim to find the impact of other factors on the proper calculation of HRV. In this paper, we research the relation between HRV and the age and gender of the patient to adjust the threshold correspondingly to the noninvasive glucose estimator that we are developing and improve its performance. While most of the literature research so far addresses healthy patients and only short- or long-term HRV, we apply a more holistic approach by including both healthy patients and patients with arrhythmia and different lengths of HRV measurements (short, middle, and long). The methods necessary to determine the correlation are (i) point biserial correlation, (ii) Pearson correlation, and (iii) Spearman rank correlation. We developed a mathematical model of a linear or monotonic dependence function and a machine learning and deep learning model, building a classification detector and level estimator. We used electrocardiogram (ECG) data from 4 different datasets consisting of 284 subjects. Age and gender influence HRV with a moderate correlation value of 0.58. This work elucidates the intricate interplay between individual input and output parameters compared with previous efforts, where correlations were found between HRV and blood glucose levels using deep learning techniques. It can successfully detect the influence of each input.

Improving the QRS detection for one-channel ECG sensor.

We analyzed several QRS detection algorithms in order to build a quality industrial beat detector, intended for a small, wearable, one channel electrocardiogram sensor with a sampling rate of 125 Hz, and analog-to-digital conversion of 10 bits. The research was a lengthy process that included building several hundred rules to cope with the QRS detection problems and finding an optimal threshold value for several parameters. We obtained 99.90% QRS sensitivity and 99.90% QRS positive predictive rate measured on the first channel of rescaled and resampled MIT-BIH Arrhythmia ECG database. Even more so, our solution works better than the algorithms for the original signals with a sampling rate of 360 Hz and analog-to-digital conversion of 11 bits.