Detalhe da pesquisa
1.
Discovery of a novel tricyclic 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity.
Bioorg Med Chem Lett
; 25(17): 3582-4, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26164189
2.
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3575-81, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26199119
3.
Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3569-74, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26206504
4.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem
; 65(12): 8345-8379, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500094
5.
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
J Med Chem
; 65(24): 16173-16203, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36399068
6.
Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.
BMC Cancer
; 11: 24, 2011 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21247487
7.
A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.
Elife
; 42015 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25965177
8.
Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.
Elife
; 52016 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27852439