Detalhe da pesquisa
1.
Alzheimer's-Causing Mutations Shift Aß Length by Destabilizing γ-Secretase-Aßn Interactions.
Cell
; 170(3): 443-456.e14, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28753424
2.
Alzheimer's-causing mutations shift Aß length by destabilizing γ-secretase-Aßn interactions.
Cell
; 184(8): 2257-2258, 2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33861967
3.
Signaling is silver, silence is golden: RHBDL2 intramembrane proteolysis prevents stochastic Ca2+ signaling in unstimulated cells.
Mol Cell
; 81(23): 4763-4765, 2021 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34861185
4.
The gut metabolite indole-3 propionate promotes nerve regeneration and repair.
Nature
; 607(7919): 585-592, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35732737
5.
APP substrate ectodomain defines amyloid-ß peptide length by restraining γ-secretase processivity and facilitating product release.
EMBO J
; 42(23): e114372, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37853914
6.
Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
EMBO J
; 41(21): e111084, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36121025
7.
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.
J Biol Chem
; 300(1): 105533, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38072061
8.
Dysregulated Lipid Metabolism Networks Modulate T-cell Function in People with Relapsing Remitting Multiple Sclerosis.
Clin Exp Immunol
; 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38625017
9.
Serum biomarker levels predict disability progression in patients with primary progressive multiple sclerosis.
J Neurol Neurosurg Psychiatry
; 95(5): 410-418, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37940409
10.
LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function.
Proc Natl Acad Sci U S A
; 118(21)2021 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34006637
11.
Extracellular interface between APP and Nicastrin regulates Aß length and response to γ-secretase modulators.
EMBO J
; 38(12)2019 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31109937
12.
Systemic lupus erythematosus patients have unique changes in serum metabolic profiles across age associated with cardiometabolic risk.
Rheumatology (Oxford)
; 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38048621
13.
Aß profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset.
Mol Psychiatry
; 27(6): 2821-2832, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35365805
14.
Involvement of Bcl-2 Family Proteins in Tetraploidization-Related Senescence.
Int J Mol Sci
; 24(7)2023 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37047342
15.
Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease.
Semin Cell Dev Biol
; 105: 75-85, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32418657
16.
Ultrasmall Manganese Ferrites for In Vivo Catalase Mimicking Activity and Multimodal Bioimaging.
Small
; 18(16): e2106570, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35263020
17.
Developing high-quality value-added cereals for organic systems in the US Upper Midwest: hard red winter wheat (Triticum aestivum L.) breeding.
Theor Appl Genet
; 135(11): 4005-4027, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-35633380
18.
Plasma amyloid-ß ratios in autosomal dominant Alzheimer's disease: the influence of genotype.
Brain
; 144(10): 2964-2970, 2021 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33892504
19.
Different coatings on magnetic nanoparticles dictate their degradation kinetics in vivo for 15 months after intravenous administration in mice.
J Nanobiotechnology
; 20(1): 543, 2022 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36578018
20.
Severe COVID-19 in patients with immune-mediated rheumatic diseases: a stratified analysis from the SORCOM multicenter registry.
Mod Rheumatol
; 2022 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36516217