RESUMO
The commonly expressed goal of biodiversity offsets is to achieve no net loss of specific biological features affected by development. However, strict equivalency requirements may complicate trading of offset credits, increase costs due to restricted offset placement options, and force offset activities to focus on features that may not represent regional conservation priorities. Using the oil sands industry of Alberta, Canada, as a case study, we evaluated the economic and ecological performance of alternative offset systems targeting either ecologically equivalent areas (vegetation types) or regional conservation priorities (caribou and the Dry Mixedwood natural subregion). Exchanging dissimilar biodiversity elements requires assessment via a generalized metric; we used an empirically derived index of biodiversity intactness to link offsets with losses incurred by development. We considered 2 offset activities: land protection, with costs estimated as the net present value of profits of petroleum and timber resources to be paid as compensation to resource tenure holders, and restoration of anthropogenic footprint, with costs estimated from existing restoration projects. We used the spatial optimization tool MARXAN to develop hypothetical offset networks that met either the equivalent-vegetation or conservation-priority targets. Networks that required offsetting equivalent vegetation cost 2-17 times more than priority-focused networks. This finding calls into question the prudence of equivalency-based systems, particularly in relatively undeveloped jurisdictions, where conservation focuses on limiting and directing future losses. Priority-focused offsets may offer benefits to industry and environmental stakeholders by allowing for lower-cost conservation of valued ecological features and may invite discussion on what land-use trade-offs are acceptable when trading biodiversity via offsets. Resultados Económicos y Ecológicos de Sistemas de Compensación de Biodiversidad Flexible Habib et al.
Assuntos
Biodiversidade , Conservação dos Recursos Naturais/métodos , Alberta , Animais , Simulação por Computador , Mineração , Rena/fisiologia , Software , ÁrvoresRESUMO
Reliable data on the provision of ecosystem services (ES) is essential to the design and implementation of policies that incorporate ES into grassland conservation and restoration. We developed and applied an innovative approach for regional parameterization, and calibration of the CENTURY ecosystem model. We quantified spatiotemporal variation of soil organic carbon stock (SOC) and aboveground plant biomass production (AGB) and examined their responses to the recent climate change across a diverse range of native grassland systems in Alberta, western Canada. The simultaneous integration of SOC and AGB into calibration and analysis accounted for most of the spatiotemporal variability in the SOC and AGB measurements and resulted in reduced simulation uncertainty across nine grassland regions. These findings suggest the importance of the systematic parameterization and calibration for the reliable assessment of carbon-related ES across a wide geographic area with heterogeneous ecological conditions. Simulation results showed a pronounced variation in the spatial distribution of SOC and AGB and their associated uncertainty across grassland regions. Under baseline grazing intensity regime, an overall negative effect of recent climatic changes on the SOC, and a less consistent effect on the AGB were found. While, an overall positive or slightly negative impact of recent climate change on the SOC and AGB was found under a proposed 10% lower grazing intensity regime. These heterogeneities in the magnitude and direction of climate change effects under different grazing regimes suggest needs for a range of climate change adaptation strategies to maintain carbon-related ES in Alberta's grasslands. The modeling framework developed in this study can be used to improve the spatially explicit assessment of carbon-related ES in other geographically vast grassland areas and examine the effectiveness of alternative management scenarios to ensure the long-term provision of carbon-related ES in grassland systems.
Assuntos
Carbono/análise , Ecossistema , Monitoramento Ambiental , Pradaria , AlbertaRESUMO
OBJECTIVE: Identify population pharmacokinetics and pharmacodynamic target attainment of gentamicin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN: Prospective open-label pharmacokinetic study. Gentamicin concentrations were modeled and dosing regimens simulated for a 5000-patient neonatal population with HIE receiving CH using PMetrics, a nonparametric, pharmacometric modeling, and simulation package for R. SETTING: A 189-bed children's tertiary care teaching hospital. RESULTS: Twelve patients, 5 (42%) females and 7 (58%) males, met inclusion criteria with a median gestation age of 39.9 weeks (interquartile range [IQR] 38.5-40.2 wks) and a median birthweight (BW) of 3.3 kg (IQR 3.1-3.7 kg). Gentamicin concentrations were best described by a two-compartment model with first-order elimination with BW as a covariate on volume of distribution (Vd). The mean total body population clearance (CL) was 2.2 ± 0.7 ml/minute/kg, and the volume of the central compartment was 0.44 ± 0.06 L/kg. The R2 , bias, and precision for the observed versus population predicted model were 0.917, 1.15, and 10.9 µg/ml; the R2 , bias, and precision for the observed versus individual predicted model were 0.982, -0.132, and 0.932 µg/ml, respectively. The calculated mean population estimate for the total Vd was 0.96 ± 0.4 L/kg. The dosing regimen that most consistently produced a maximum concentration (Cmax ) in the range of 10-12 mg/L with a minimum concentration (Cmin ) level less than 2 mg/L was 5 mg/kg/dose given every 36 hours. CONCLUSION: These data suggest the population pharmacokinetics of gentamicin in neonates with HIE receiving CH have an increase in gentamicin CL and are different from previous reports in neonates with HIE not receiving CH and/or neonates without HIE. This analysis suggests a dosing regimen of 5 mg/kg/dose every 36 hours results in a gentamicin Cmax within the range of 10-12 mg/L with a Cmin lower than 2 mg/L, which is appropriate for treating susceptible gram-negative organisms with minimum inhibitory concentrations of 1 mg/L or lower.
Assuntos
Antibacterianos/farmacocinética , Gentamicinas/farmacocinética , Hipotermia Induzida , Hipóxia-Isquemia Encefálica/metabolismo , Hipóxia-Isquemia Encefálica/terapia , Peso ao Nascer , Simulação por Computador , Feminino , Humanos , Recém-Nascido , Masculino , Método de Monte Carlo , População , Estudos ProspectivosRESUMO
The science of ecosystem service (ES) mapping has become increasingly sophisticated over the past 20 years, and examples of successfully integrating ES into management decisions at national and sub-national scales have begun to emerge. However, increasing model sophistication and accuracy-and therefore complexity-may trade-off with ease of use and applicability to real-world decision-making contexts, so it is vital to incorporate the lessons learned from implementation efforts into new model development. Using successful implementation efforts for guidance, we developed an integrated ES modelling system to quantify several ecosystem services: forest timber production and carbon storage, water purification, pollination, and biodiversity. The system is designed to facilitate uptake of ES information into land-use decisions through three principal considerations: (1) using relatively straightforward models that can be readily deployed and interpreted without specialized expertise; (2) using an agent-based modelling framework to enable the incorporation of human decision-making directly within the model; and (3) integration among all ES models to simultaneously demonstrate the effects of a single land-use decision on multiple ES. We present an implementation of the model for a major watershed in Alberta, Canada, and highlight the system's capabilities to assess a suite of ES under future management decisions, including forestry activities under two alternative timber harvest strategies, and through a scenario modelling analysis exploring different intensities of hypothetical agricultural expansion. By using a modular approach, the modelling system can be readily expanded to evaluate additional ecosystem services or management questions of interest in order to guide land-use decisions to achieve socioeconomic and environmental objectives.