Detalhe da pesquisa
1.
Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease.
Biochem Biophys Res Commun
; 695: 149418, 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38176171
2.
Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer.
Biochem Biophys Res Commun
; 643: 48-54, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36586158
3.
Targeting Methionine Addiction of Cancer Cells with Methioninase.
Biochemistry (Mosc)
; 88(7): 944-952, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37751865
4.
Superiority of [11C]methionine over [18F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer.
Int J Mol Sci
; 24(3)2023 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36768257
5.
Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells.
Biochem Biophys Res Commun
; 533(4): 1034-1038, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33019978
6.
Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model.
Biochem Biophys Res Commun
; 523(1): 135-139, 2020 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31839218
7.
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
Biochem Biophys Res Commun
; 518(2): 306-310, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31421825
8.
Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.
J Cell Biochem
; 119(4): 3537-3544, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29143983
9.
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma.
Biochem Biophys Res Commun
; 503(4): 3086-3092, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30166061
10.
Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.
Chemotherapy
; 63(5): 278-283, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30673664
11.
Efficacy of Recombinant Methioninase on Late-stage Patient Cancer in the Histoculture Drug Response Assay (HDRA) as a Potential Functional Biomarker of Sensitivity to Methionine-restriction Therapy in the Clinic.
Cancer Diagn Progn
; 4(3): 239-243, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38707720
12.
Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells.
Anticancer Res
; 44(3): 929-933, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38423628
13.
[11C] Methionine-PET Imaging as a Cancer Biomarker for Methionine Addiction and Sensitivity to Methionine-restriction-based Combination Chemotherapy.
In Vivo
; 38(1): 253-258, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38148095
14.
Reduction of Tumor Biomarkers from very High to Normal and Extensive Metastatic Lesions to Undetectability in a Patient With Stage IV HER2-positive Breast Cancer Treated With Low-dose Trastuzumab Deruxtecan in Combination With Oral Recombinant Methioninase and a Low-methionine Diet.
Anticancer Res
; 44(4): 1499-1504, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38538002
15.
Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet.
In Vivo
; 38(3): 1459-1464, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38688589
16.
Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts.
Anticancer Res
; 44(3): 921-928, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38423656
17.
Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model.
In Vivo
; 38(3): 1058-1063, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38688611
18.
Recombinant Methioninase Decreased the Effective Dose of Irinotecan by 15-fold Against Colon Cancer Cells: A Strategy for Effective Low-toxicity Treatment of Colon Cancer.
Anticancer Res
; 44(1): 31-35, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38159986
19.
Rapid Reduction of CEA and Stable Metastasis in an NRAS-mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment Alone.
In Vivo
; 37(5): 2134-2138, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37652473
20.
Recombinant Oral Methioninase (o-rMETase) Combined With Oxaliplatinum Plus 5-Fluorouracil Improves Survival of Mice With Massive Colon-Cancer Peritoneal Carcinomatosis.
Anticancer Res
; 43(1): 19-24, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36585181