Detalhe da pesquisa
1.
BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
Nature
; 592(7853): 283-289, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524990
2.
Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Nucleic Acids Res
; 51(22): 12443-12458, 2023 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37930833
3.
Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.
Nucleic Acids Res
; 50(13): 7545-7559, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35801923
4.
Applications of Cryo-EM in small molecule and biologics drug design.
Biochem Soc Trans
; 49(6): 2627-2638, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34812853
5.
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype.
Proc Natl Acad Sci U S A
; 115(48): 12301-12306, 2018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30429323
6.
Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.
J Lipid Res
; 61(8): 1192-1202, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32482718
7.
Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.
Protein Expr Purif
; 110: 22-9, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25620107
8.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem J
; 460(2): 211-22, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24593284
9.
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Bioorg Med Chem Lett
; 24(17): 4132-40, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25113930
10.
In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).
ACS Med Chem Lett
; 15(4): 540-545, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628800
11.
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
Bioorg Med Chem Lett
; 23(3): 767-72, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265881
12.
Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
Bioorg Med Chem Lett
; 23(6): 1727-31, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23414806
13.
Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Proc Natl Acad Sci U S A
; 107(51): 22002-7, 2010 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21135211
14.
Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies.
bioRxiv
; 2023 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398126
15.
Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine.
Sci Transl Med
; 15(693): eade6422, 2023 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37023209
16.
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun
; 14(1): 5938, 2023 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37741852
17.
Structural basis of the acyl-transfer mechanism of human GPAT1.
Nat Struct Mol Biol
; 30(1): 22-30, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36522428
18.
Early insights into the interactions of different ß-lactam antibiotics and ß-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.
Antimicrob Agents Chemother
; 56(11): 5687-92, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22908165
19.
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
Bioorg Med Chem Lett
; 22(18): 5989-94, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892121
20.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153798