Detalhe da pesquisa
1.
The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities.
Drug Metab Dispos
; 51(7): 892-901, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37041083
2.
ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs).
Xenobiotica
; 52(8): 770-785, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314242
3.
Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes.
Drug Metab Dispos
; 49(4): 314-321, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33472814
4.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment.
Drug Metab Dispos
; 49(1): 94-110, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139460
5.
Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation.
J Chem Inf Model
; 60(4): 2091-2099, 2020 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32131596
6.
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.
Drug Metab Dispos
; 47(10): 1206-1221, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439574
7.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.
Drug Metab Dispos
; 46(9): 1285-1303, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959133
8.
Assessment of Transporter-Mediated and Passive Hepatic Uptake Clearance Using Rifamycin-SV as a Pan-Inhibitor of Active Uptake.
Mol Pharm
; 15(10): 4677-4688, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29996058
9.
Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions.
Drug Metab Dispos
; 45(6): 692-705, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28336578
10.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28646080
11.
Evaluation of the Interplay between Uptake Transport and CYP3A4 Induction in Micropatterned Cocultured Hepatocytes.
Drug Metab Dispos
; 44(12): 1910-1919, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27655038
12.
Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes.
Drug Metab Dispos
; 44(2): 250-61, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658225
13.
VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions.
Drug Metab Dispos
; 44(8): 1286-95, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27298338
14.
Aminobenzotriazole inhibits and induces several key drug metabolizing enzymes complicating its utility as a pan CYP inhibitor for reaction phenotyping.
Clin Transl Sci
; 17(3): e13746, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38501263
15.
Quantitative evaluation of trastuzumab deruxtecan pharmacokinetics and pharmacodynamics in mouse models of varying degrees of HER2 expression.
CPT Pharmacometrics Syst Pharmacol
; 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38532525
16.
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J Med Chem
; 67(2): 1500-1512, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227216
17.
Pharmacokinetic evaluation of poorly soluble compounds formulated as nano- or microcrystals after intraperitoneal injection to mice.
Int J Pharm
; 636: 122787, 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36894042
18.
Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles.
PLoS One
; 18(5): e0285798, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37195991
19.
A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models.
AAPS J
; 25(4): 66, 2023 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37380821
20.
Challenges and Opportunities for Improved Drug-Drug Interaction Predictions for Renal OCT2 and MATE1/2-K Transporters.
Clin Pharmacol Ther
; 112(3): 562-572, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35598119