Detalhe da pesquisa
1.
Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.
Bioorg Med Chem
; 23(13): 3351-67, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25960322
2.
Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.
Bioorg Med Chem
; 23(2): 297-313, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25515954
3.
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.
Bioorg Med Chem Lett
; 19(16): 4679-83, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608416
4.
Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.
J Med Chem
; 51(6): 1925-44, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18307290
5.
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.
Bioorg Med Chem Lett
; 18(18): 5037-40, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18752946
6.
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors.
FEBS Lett
; 579(6): 1389-93, 2005 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15733846
7.
Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists.
J Med Chem
; 48(9): 3103-6, 2005 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15857112
8.
Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase.
FEBS Lett
; 556(1-3): 43-6, 2004 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-14706823
9.
Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.
J Med Chem
; 47(17): 4151-4, 2004 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-15293985
10.
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
J Med Chem
; 52(9): 3063-72, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19366244
11.
Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.
J Med Chem
; 51(15): 4804-22, 2008 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18651730
12.
Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.
J Med Chem
; 51(13): 4002-20, 2008 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18553954
13.
Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase.
Bioorg Med Chem Lett
; 17(20): 5577-81, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17804225
14.
Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5.
Bioorg Med Chem Lett
; 16(17): 4475-8, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16824754
15.
Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6.
Bioorg Med Chem Lett
; 16(18): 4861-4, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16837197
16.
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling.
Bioorg Med Chem
; 14(5): 1378-90, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16288880
17.
4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.
Bioorg Med Chem Lett
; 15(19): 4221-5, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16098744
18.
Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4.
Bioorg Med Chem Lett
; 15(13): 3284-7, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15935659
19.
Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
Bioorg Med Chem Lett
; 15(13): 3279-83, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15935660
20.
Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.
Bioorg Med Chem Lett
; 15(12): 3091-5, 2005 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15914004