Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8⁺ T cell exhaustion.

Tillé, Laure; Cropp, Daniela; Charmoy, Mélanie; Reichenbach, Patrick; Andreatta, Massimo; Wyss, Tania; Bodley, Gabrielle; Crespo, Isaac; Nassiri, Sina; Lourenco, Joao; Leblond, Marine M; Lopez-Rodriguez, Cristina; Speiser, Daniel E; Coukos, George; Irving, Melita; Carmona, Santiago J; Held, Werner; Verdeil, Grégory.

Nat Immunol ; 24(10): 1645-1653, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37709986

2.

Metabolic reprogramming of terminally exhausted CD8⁺ T cells by IL-10 enhances anti-tumor immunity.

Guo, Yugang; Xie, Yu-Qing; Gao, Min; Zhao, Yang; Franco, Fabien; Wenes, Mathias; Siddiqui, Imran; Bevilacqua, Alessio; Wang, Haiping; Yang, Hanshuo; Feng, Bing; Xie, Xin; Sabatel, Catherine M; Tschumi, Benjamin; Chaiboonchoe, Amphun; Wang, Yuxi; Li, Weimin; Xiao, Weihua; Held, Werner; Romero, Pedro; Ho, Ping-Chih; Tang, Li.

Nat Immunol ; 22(6): 746-756, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-34031618

3.

Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.

Sacirbegovic, Faruk; Günther, Matthias; Greco, Alessandro; Zhao, Daqiang; Wang, Xi; Zhou, Meng; Rosenberger, Sarah; Oberbarnscheidt, Martin H; Held, Werner; McNiff, Jennifer; Jain, Dhanpat; Höfer, Thomas; Shlomchik, Warren D.

Immunity ; 56(2): 369-385.e6, 2023 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-36720219

4.

The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1⁺ CD8⁺ T cells in chronic viral infection.

Marx, Anna-Friederike; Kallert, Sandra M; Brunner, Tobias M; Villegas, José A; Geier, Florian; Fixemer, Jonas; Abreu-Mota, Tiago; Reuther, Peter; Bonilla, Weldy V; Fadejeva, Jelizaveta; Kreutzfeldt, Mario; Wagner, Ingrid; Aparicio-Domingo, Patricia; Scarpellino, Leo; Charmoy, Mélanie; Utzschneider, Daniel T; Hagedorn, Claudia; Lu, Min; Cornille, Karen; Stauffer, Karsten; Kreppel, Florian; Merkler, Doron; Zehn, Dietmar; Held, Werner; Luther, Sanjiv A; Löhning, Max; Pinschewer, Daniel D.

Immunity ; 56(4): 813-828.e10, 2023 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-36809763

5.

Central memory CD8⁺ T cells derive from stem-like Tcf7^hi effector cells in the absence of cytotoxic differentiation.

Pais Ferreira, Daniela; Silva, Joana Gomes; Wyss, Tania; Fuertes Marraco, Silvia A; Scarpellino, Léonardo; Charmoy, Mélanie; Maas, Roeltje; Siddiqui, Imran; Tang, Li; Joyce, Johanna A; Delorenzi, Mauro; Luther, Sanjiv A; Speiser, Daniel E; Held, Werner.

Immunity ; 53(5): 985-1000.e11, 2020 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-33128876

6.

Intratumoral Tcf1⁺PD-1⁺CD8⁺ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.

Siddiqui, Imran; Schaeuble, Karin; Chennupati, Vijaykumar; Fuertes Marraco, Silvia A; Calderon-Copete, Sandra; Pais Ferreira, Daniela; Carmona, Santiago J; Scarpellino, Leonardo; Gfeller, David; Pradervand, Sylvain; Luther, Sanjiv A; Speiser, Daniel E; Held, Werner.

Immunity ; 50(1): 195-211.e10, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-30635237

7.

Hugh Robson MacDonald (1946-2023).

Wilson, Anne; Ferrero, Isabel; Speiser, Daniel E; Held, Werner; Romero, Pedro.

Immunity ; 56(5): 893-894, 2023 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-37163986

8.

Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells.

Chennupati, Vijaykumar; Held, Werner.

Immunity ; 47(6): 1009-1011, 2017 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-29262341

9.

T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections.

Utzschneider, Daniel T; Charmoy, Mélanie; Chennupati, Vijaykumar; Pousse, Laurène; Ferreira, Daniela Pais; Calderon-Copete, Sandra; Danilo, Maxime; Alfei, Francesca; Hofmann, Maike; Wieland, Dominik; Pradervand, Sylvain; Thimme, Robert; Zehn, Dietmar; Held, Werner.

Immunity ; 45(2): 415-27, 2016 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-27533016

10.

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.

Dudda, Jan C; Salaun, Bruno; Ji, Yun; Palmer, Douglas C; Monnot, Gwennaelle C; Merck, Estelle; Boudousquie, Caroline; Utzschneider, Daniel T; Escobar, Thelma M; Perret, Rachel; Muljo, Stefan A; Hebeisen, Michael; Rufer, Nathalie; Zehn, Dietmar; Donda, Alena; Restifo, Nicholas P; Held, Werner; Gattinoni, Luca; Romero, Pedro.

Immunity ; 38(4): 742-53, 2013 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-23601686

11.

Nonclassical NK cell education.

Held, Werner.

Nat Immunol ; 13(12): 1135-7, 2012 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23160207

12.

Transcriptional regulation of murine natural killer cell development, differentiation and maturation.

Held, Werner; Jeevan-Raj, Beena; Charmoy, Mélanie.

Cell Mol Life Sci ; 75(18): 3371-3379, 2018 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-29959459

13.

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.

Jaworski, Maike; Marsland, Ben J; Gehrig, Jasmine; Held, Werner; Favre, Stéphanie; Luther, Sanjiv A; Perroud, Mai; Golshayan, Déla; Gaide, Olivier; Thome, Margot.

EMBO J ; 33(23): 2765-81, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-25319413

14.

Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.

Back, Jonathan; Malchiodi, Emilio L; Cho, Sangwoo; Scarpellino, Léonardo; Schneider, Pascal; Kerzic, Melissa C; Mariuzza, Roy A; Held, Werner.

Immunity ; 31(4): 598-608, 2009 Oct 16.

Artigo em Inglês | MEDLINE | ID: mdl-19818651

15.

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

Chalifour, Anick; Scarpellino, Léonardo; Back, Jonathan; Brodin, Petter; Devèvre, Estelle; Gros, Frédéric; Lévy, Frédéric; Leclercq, Georges; Höglund, Petter; Beermann, Friedrich; Held, Werner.

Immunity ; 30(3): 337-47, 2009 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-19249231

16.

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.

Hurrell, Benjamin P; Schuster, Steffen; Grün, Eva; Coutaz, Manuel; Williams, Roderick A; Held, Werner; Malissen, Bernard; Malissen, Marie; Yousefi, Shida; Simon, Hans-Uwe; Müller, Andreas J; Tacchini-Cottier, Fabienne.

PLoS Pathog ; 11(5): e1004929, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-26020515

17.

Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 T cells with distinct recall proliferation capacity.

Boudousquié, Caroline; Danilo, Maxime; Pousse, Laurène; Jeevan-Raj, Beena; Angelov, Georgi S; Chennupati, Vijaykumar; Zehn, Dietmar; Held, Werner.

J Immunol ; 193(6): 2784-91, 2014 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-25127860

18.

Inhibitory receptor-mediated regulation of natural killer cells.

Alari-Pahissa, Elisenda; Grandclément, Camille; Jeevan-Raj, Beena; Held, Werner.

Crit Rev Immunol ; 34(6): 455-65, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25597309

19.

Education of murine NK cells requires both cis and trans recognition of MHC class I molecules.

Bessoles, Stéphanie; Angelov, Georgi S; Back, Jonathan; Leclercq, Georges; Vivier, Eric; Held, Werner.

J Immunol ; 191(10): 5044-51, 2013 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-24098052

20.

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.

Taveirne, Sylvie; Filtjens, Jessica; Van Ammel, Els; De Colvenaer, Veerle; Kerre, Tessa; Taghon, Tom; Vandekerckhove, Bart; Plum, Jean; Held, Werner; Leclercq, Georges.

Blood ; 118(2): 339-47, 2011 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-21613250

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