Detalhe da pesquisa
1.
Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.
Invest New Drugs
; 38(6): 1796-1806, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32451663
2.
Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.
Drug Metab Dispos
; 47(6): 648-656, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940629
3.
Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease.
J Lipid Res
; 59(9): 1640-1648, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30021760
4.
Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.
J Pharmacol Exp Ther
; 367(3): 414-424, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30228112
5.
Delayed methotrexate elimination: Incidence, interaction with antacid drugs, and clinical consequences?
Hematol Oncol
; 36(2): 399-406, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28983943
6.
Pharmacokinetic interactions in mice between irinotecan and MBL-II-141, an ABCG2 inhibitor.
Biopharm Drug Dispos
; 38(5): 351-362, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28207160
7.
Revisiting dosing regimen using PK/PD modeling: the MODEL1 phase I/II trial of docetaxel plus epirubicin in metastatic breast cancer patients.
Breast Cancer Res Treat
; 156(2): 331-41, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27002506
8.
Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions.
Pharm Res
; 33(3): 751-62, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26553354
9.
Validation of the Predictive Value of Modeled Human Chorionic Gonadotrophin Residual Production in Low-Risk Gestational Trophoblastic Neoplasia Patients Treated in NRG Oncology/Gynecologic Oncology Group-174 Phase III Trial.
Int J Gynecol Cancer
; 26(1): 208-15, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26569059
10.
Comparing probabilistic and descriptive analyses of time-dose-toxicity relationship for determining no-observed-adverse-effect level in drug development.
Toxicol Appl Pharmacol
; 288(2): 240-8, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26232187
11.
Multiparameter Phase I trials: a tool for model-based development of targeted agent combinations--example of EVESOR trial.
Future Oncol
; 11(10): 1511-8, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25963428
12.
Dynamic modeling in ovarian cancer: an original approach linking early changes in modeled longitudinal CA-125 kinetics and survival to help decisions in early drug development.
Gynecol Oncol
; 133(3): 460-6, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24726614
13.
Solid oral forms availability in children: a cost saving investigation.
Br J Clin Pharmacol
; 78(5): 1080-9, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24965935
14.
Identification of the primary mechanism of action of an insulin secretagogue from meal test data in healthy volunteers based on an integrated glucose-insulin model.
J Pharmacokinet Pharmacodyn
; 40(1): 1-10, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23179858
15.
Model-based design of rituximab dosage optimization in follicular non-Hodgkin's lymphoma.
Br J Clin Pharmacol
; 73(4): 597-605, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21999172
16.
Chemotherapeutic errors in hospitalised cancer patients: attributable damage and extra costs.
BMC Cancer
; 11: 478, 2011 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22067636
17.
Therapeutic Drug Monitoring Strategies for Envarsus in De Novo Kidney Transplant Patients Using Population Modelling and Simulations.
Adv Ther
; 38(10): 5317-5332, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34515977
18.
Prognostic value of modeled PSA clearance on biochemical relapse free survival after radical prostatectomy.
Prostate
; 69(12): 1325-33, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19475643
19.
Development of a drug-disease simulation model for rituximab in follicular non-Hodgkin's lymphoma.
Br J Clin Pharmacol
; 68(4): 561-73, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19843059
20.
Time-to-Event Modeling of Left- or Right-Censored Toxicity Data in Nonclinical Drug Toxicology.
Toxicol Sci
; 165(1): 50-60, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29788384