Detalhe da pesquisa
1.
Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates.
Haematologica
; 107(2): 519-531, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33567808
2.
Antisense Oligonucleotide-Related Macrovesicular Vacuolation of Hippocampal Neurons in Nonhuman Primates.
Toxicol Pathol
; 50(2): 197-210, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35042440
3.
Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6.
J Pharmacol Exp Ther
; 377(1): 51-63, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33431610
4.
Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice.
Toxicol Pathol
; 47(1): 82-92, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30585133
5.
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
Nucleic Acids Res
; 44(5): 2093-109, 2016 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26553810
6.
Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide.
Mol Vis
; 23: 561-571, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28855795
7.
Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.
Mol Ther
; 24(10): 1771-1782, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357629
8.
Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides.
Toxicol Pathol
; 43(7): 935-44, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25717082
9.
Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part I. Biotherapeutics.
Toxicol Pathol
; 43(7): 915-34, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25722122
10.
Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.
J Pharmacol Exp Ther
; 351(3): 709-17, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25301170
11.
Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates.
J Pharmacol Exp Ther
; 350(1): 46-55, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24784568
12.
Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys.
Blood
; 119(10): 2401-8, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22246038
13.
Local and systemic tolerability of a 2'O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey.
Inhal Toxicol
; 26(8): 452-63, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24932560
14.
Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.
Mediators Inflamm
; 2014: 353614, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24803739
15.
Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events.
Clin Transl Sci
; 16(4): 575-580, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36631935
16.
Complement C3d/C4d Deposition on Platelets Correlates with 2'-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys.
Nucleic Acid Ther
; 33(3): 209-225, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37093125
17.
Pharmacodynamics and subchronic toxicity in mice and monkeys of ISIS 388626, a second-generation antisense oligonucleotide that targets human sodium glucose cotransporter 2.
J Pharmacol Exp Ther
; 343(2): 489-96, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22915769
18.
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
J Pharmacol Exp Ther
; 342(1): 150-62, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505629
19.
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells.
Nucleic Acid Ther
; 32(6): 457-472, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35976085
20.
Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells.
Nucleic Acid Ther
; 32(6): 473-485, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355073