Detalhe da pesquisa
1.
Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
EMBO J
; 41(21): e111084, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36121025
2.
Intramembrane client recognition potentiates the chaperone functions of calnexin.
EMBO J
; 41(24): e110959, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314723
3.
Extracellular interface between APP and Nicastrin regulates Aß length and response to γ-secretase modulators.
EMBO J
; 38(12)2019 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31109937
4.
A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites.
Angew Chem Int Ed Engl
; 62(31): e202304533, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37249408
5.
The dynamics of γ-secretase and its substrates.
Semin Cell Dev Biol
; 105: 86-101, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32423851
6.
Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains.
J Biol Chem
; 296: 100334, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508322
7.
CHARMM-GUI supports the Amber force fields.
J Chem Phys
; 153(3): 035103, 2020 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32716185
8.
The influence of metal-ion binding on the structure and surface composition of Sonic Hedgehog: a combined classical and hybrid QM/MM MD study.
Phys Chem Chem Phys
; 18(32): 22254-65, 2016 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27452578
9.
Probing the range of applicability of structure- and energy-adjusted QM/MM link bonds.
J Comput Chem
; 36(26): 1929-39, 2015 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26235898
10.
Tuning the reactivity of a dissociative force field: proton transfer properties of aqueous H3O(+) and their dependence on the three-body interaction.
Phys Chem Chem Phys
; 17(16): 10934-43, 2015 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25820273
11.
Characterizing ATP processing by the AAA+ protein p97 at the atomic level.
Nat Chem
; 16(3): 363-372, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38326645
12.
Solvation properties and behaviour of lutetium(III) in aqueous solution--a quantum mechanical charge field (QMCF) study.
J Chem Phys
; 139(11): 114306, 2013 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070289
13.
Structural basis of metabolite transport by the chloroplast outer envelope channel OEP21.
Nat Struct Mol Biol
; 30(6): 761-769, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37156968
14.
Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.
Nat Commun
; 13(1): 85, 2022 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35013242
15.
Amyloid fibril structure from the vascular variant of systemic AA amyloidosis.
Nat Commun
; 13(1): 7261, 2022 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36433936
16.
The human signal peptidase complex acts as a quality control enzyme for membrane proteins.
Science
; 378(6623): 996-1000, 2022 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36454823
17.
Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of γ-Secretase.
ACS Chem Neurosci
; 11(24): 4426-4433, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33232115
18.
Uncovering the Binding Mode of γ -Secretase Inhibitors.
ACS Chem Neurosci
; 10(8): 3398-3403, 2019 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244051
19.
γ-Secretase Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding.
Front Chem
; 6: 640, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30662893
20.
The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study.
Front Chem
; 5: 76, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29109946