Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: two novel aldose reductase inhibitors.

Sorbitol, resulting from glucose metabolism through aldose reductase, may play a role in diabetic complications such as cataracts, neuropathy, and vasculopathy. Sulindac (Clinoril) and sorbinil, two inhibitors of aldose reductase, decreased sorbitol formation in cataract or nerve tissue incubated in high glucose TC-199 media. Sulindac, a widely used anti-rheumatic drug, may have clinical applications in preventing diabetic complications.

The labrum of the calcaneocuboid joint.

The authors describe a previously unreported anatomical structure in the calcaneocuboid joint of the foot and discuss the clinical significance. Fibroadipose synovial folds or labra are present in different locations throughout the calcaneocuboid joint of the foot. They appear to be wedge-shaped infections attached to the joint capsule in areas of incongruent joint spaces. Their surface is covered with synovial cells with a highly vascular loose connective tissue sublayer. Nerve fibers were seen in association with the joint capsule, but not within the V-shaped labrum. The clinical significance of the presence of the labrum is discussed, but their function is uncertain. These structures can project up to half the joint distance and have the possibility of producing impingement syndromes, or even tears. Since they are covered with two to three layers of synoviocytes, they also have the ability to produce a synovitis. The labrum can be identified using MRI, and once their presence is known arthroscopic repair of these structures is theoretically possible.