Detalhe da pesquisa
1.
Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.
Neurobiol Dis
; 169: 105734, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35462006
2.
Defense Automated Neurobehavioral Assessment Accurately Measures Cognition in Patients Undergoing Electroconvulsive Therapy for Major Depressive Disorder.
J ECT
; 34(1): 14-20, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991066
3.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.
Mol Pharm
; 14(10): 3248-3257, 2017 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28763226
4.
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease.
Res Sq
; 2023 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37502930
5.
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model.
Transl Neurodegener
; 12(1): 56, 2023 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049923
6.
Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice.
Brain Behav Immun Health
; 23: 100478, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35734753
7.
Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice.
Pharmaceutics
; 14(10)2022 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36297501
8.
Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis.
Nanotheranostics
; 6(2): 126-142, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34976589
9.
Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.
Drug Discov Today
; 26(7): 1656-1668, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33798648
10.
Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.
J Alzheimers Dis
; 77(1): 437-447, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32675407
11.
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
J Med Chem
; 63(11): 6028-6056, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32298582
12.
The NAAG'ing Concerns of Modeling Human Alzheimer's Disease in Mice.
J Alzheimers Dis
; 68(3): 939-945, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30883361
13.
Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
Neurol Neuroimmunol Neuroinflamm
; 6(6)2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467038
14.
Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis.
Brain Res
; 1635: 105-12, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26826008
15.
FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities.
JCI Insight
; 1(12)2016 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27536732
16.
Cognition, mood, and purpose in life in neuromyelitis optica spectrum disorder.
J Neurol Sci
; 362: 85-90, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944124