Detalhe da pesquisa
1.
Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband 19 Fâ NMR-Based Screening.
Angew Chem Int Ed Engl
; 59(35): 14809-14817, 2020 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32363632
2.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775713
3.
Ligandability Assessment of IL-1ß by Integrated Hit Identification Approaches.
J Med Chem
; 67(10): 8141-8160, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38728572
4.
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
ACS Chem Biol
; 18(1): 34-40, 2023 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594833
5.
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1ß.
Nat Commun
; 14(1): 5497, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679328
6.
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat Struct Mol Biol
; 13(4): 372-3, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16532006
7.
Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.
J Am Chem Soc
; 131(36): 12949-59, 2009 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19702332
8.
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
J Med Chem
; 51(8): 2481-91, 2008 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18357974
9.
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
J Mol Biol
; 355(2): 249-61, 2006 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16305800
10.
Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
J Med Chem
; 60(5): 1946-1958, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28157311
11.
Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
ACS Med Chem Lett
; 8(3): 338-343, 2017 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337327
12.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J Med Chem
; 60(13): 5717-5735, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28621538
13.
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.
Protein Sci
; 19(11): 2096-109, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20799349
14.
Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.
J Biomol NMR
; 42(2): 111-27, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18762865
15.
Aspartic proteases in drug discovery.
Curr Pharm Des
; 13(3): 271-85, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17313361
16.
Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.
Biomol NMR Assign
; 1(1): 51-3, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19636824
17.
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
Bioorg Med Chem Lett
; 15(4): 1217-20, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686945
18.
Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.
J Biol Chem
; 277(12): 10590-8, 2002 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11781316
19.
Structure and allosteric regulation of the alpha X beta 2 integrin I domain.
Proc Natl Acad Sci U S A
; 100(4): 1873-8, 2003 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12554829
20.
1,4-Diazepane-2-ones as novel inhibitors of LFA-1.
Bioorg Med Chem Lett
; 13(3): 499-502, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12565959