Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound: A Porcine Study.

Wireless capsule endoscopy has been used for the clinical examination of the gastrointestinal (GI) tract for two decades. However, most commercially available devices only utilise optical imaging to examine the GI wall surface. Using this sensing modality, pathology within the GI wall cannot be detected. Micro-ultrasound (µUS) using high-frequency (>20 MHz) ultrasound can provide a means of transmural or cross-sectional image of the GI tract. Depth of imaging is approximately 10 mm with a resolution of between 40-120 µm that is sufficient to differentiate between subsurface histologic layers of the various regions of the GI tract. Ultrasound capsule endoscopy (USCE) uses a capsule equipped with µUS transducers that are capable of imaging below the GI wall surface, offering thereby a complementary sensing technique to optical imaging capsule endoscopy. In this work, a USCE device integrated with a ∼30 MHz ultrasonic transducer was developed to capture a full 360° image of the lumen. The performance of the device was initially evaluated using a wire phantom, indicating an axial resolution of 69.0 µm and lateral resolution of 262.5 µm. Later, in vivo imaging performance was characterised in the oesophagus and small intestine of anaesthetized pigs. The reconstructed images demonstrate clear layer differentiation of the lumen wall. The tissue thicknesses measured from the B-scan images show good agreement with ex vivo images from the literature. The high-resolution ultrasound images in the in vivo porcine model achieved with this device is an encouraging preliminary step in the translation of these devices toward future clinical use.

Cable shared dual-frequency catheter for intravascular ultrasound.

This study proposes a catheter consisting of dual-frequency transducer for intravascular ultrasound. Both ultrasonic elements with different frequencies were connected to one coaxial cable to make the connection simple. The aperture size of the ultrasound elements were 0.4×0.6 mm2 and 0.3×0.4 mm2 for the low frequency element and high frequency element, respectively. The center frequency and bandwidth of the fabricated low frequency transducer were 33.8 MHz and 49.3%, respectively. Meanwhile, the center frequency and bandwidth of the high frequency transducer were 80.6 MHz and 50.3%, respectively. Imaging evaluations of wire phantom, tissue phantom and vessel tissue demonstrated good imaging capability of the dual-frequency catheter. The spatial resolution are 19 µm axially and 128 µm laterally for the high frequency transducer, and 37 µm axially and 199 µm laterally for the low frequency transducer. Band-pass filters were designed to separate the mixed echo signals. After filtering, the images from different ultrasound elements can be successfully identified, indicating the feasibility of the proposed cable shared dual-frequency imaging strategy. The proposed method has simple structure, good imaging resolution, and large penetration depth, showing good application prospect for intravascular ultrasound.

Miniature Transducer Using PNN-PZT-based Ceramic for Intravascular Ultrasound.

In this work, the development and performance evaluation of a high-frequency miniature ultrasonic transducer based on a Pb(Ni1/3Nb2/3)O3-Pb(Zr0.3Ti0.7)O3 (PNN-PZT-based) ceramic for intravascular imaging application are reported. The fabricated PNN-PZT-based ceramic possesses ultrahigh relative clamped dielectric permittivity (.S/.0 = 3409) and high electromechanical coupling capability (kt = 0.60). A 42-MHz high-frequency side-looking ultrasonic transducer probe using the PNN-PZT-based ceramic with a miniature aperture of 0.33 mm × 0.33 mm was designed and fabricated, which exhibited a wide -6 dB bandwidth of 79% and an insertion loss of -19.6 dB. High spatial resolution, including the axial resolution of 36 µm and lateral resolution of 141 µm, was determined by imaging a 13-µm tungsten wire phantom. Ex vivo intravascular ultrasound (IVUS) imaging of a porcine coronary artery was performed to show the imaging capability of the miniature transducer. The results demonstrated the great potential of PNN-PZT-based ceramic for high-resolution miniature transducers application.

Imaging-Guided Dual-Target Neuromodulation of the Mouse Brain Using Array Ultrasound.

Neuromodulation is an important method for investigating neural circuits and treating neurological and psychiatric disorders. Multiple-target neuromodulation is considered an advanced technology for the flexible optimization of modulation effects. However, traditional methods such as electrical and magnetic stimulations are not convenient for multiple-target applications due to their disadvantages of invasiveness or poor spatial resolution. Ultrasonic neuromodulation is a new noninvasive method that has gained wide attention in the field of neuroscience, and it is potentially able to support multiple-target stimulation by allocating multiple focal points in the brain using an array transducer. However, there are no reports in the literature of the efficacy of this technical concept, and an imaging tool for localizing the stimulation area for evaluating the neural effects in vivo has been lacking. In this study, we designed and fabricated a new system specifically for imaging-guided dual-target neuromodulation. The design of the array transducer and overall system is described in detail. The stimulation points were selectable on a B-mode image. In vivo experiments were carried out in mice, in which forelimbs shaking responses and electromyography outcomes were induced by changing the stimulation targets. The system could be a valuable tool for imaging-guided multiple-target stimulation in various neuroscience applications.