Detalhe da pesquisa
1.
Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
Bioorg Med Chem Lett
; 23(14): 4037-43, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23770058
2.
P2X7 receptor-mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats.
Eur J Pain
; 26(6): 1304-1321, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35388574
3.
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
J Med Chem
; 64(8): 4891-4902, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822617
4.
Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo.
Front Mol Neurosci
; 13: 568641, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33192294
5.
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.
J Med Chem
; 63(11): 6144-6163, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32420739
6.
Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases.
J Med Chem
; 62(13): 5979-6002, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30721063
7.
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.
J Med Chem
; 62(3): 1562-1576, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624926
8.
Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats.
Psychopharmacology (Berl)
; 186(2): 209-17, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16586089
9.
Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats.
Psychopharmacology (Berl)
; 179(3): 613-9, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15672274