Detalhe da pesquisa
1.
Mechanistic basis and efficacy of targeting the ß-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors.
Blood
; 135(15): 1255-1269, 2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32068780
2.
The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ß-Like 1-ß-Catenin Protein Complex.
J Pharmacol Exp Ther
; 378(2): 77-86, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34006586
3.
Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction.
BMC Biotechnol
; 19(1): 56, 2019 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375100
4.
Combination of Histone Deacetylase Inhibitor Panobinostat (LBH589) with ß-Catenin Inhibitor Tegavivint (BC2059) Exerts Significant Anti-Myeloma Activity Both In Vitro and In Vivo.
Cancers (Basel)
; 14(3)2022 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35159107
5.
Preclinical efficacy of the Wnt/ß-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors.
PLoS One
; 17(10): e0276047, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36240209
6.
Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Elife
; 62017 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28100392
7.
Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations.
Elife
; 62017 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28100394
8.
Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime ß-Catenin Pathway Inhibitors.
J Med Chem
; 58(15): 5854-62, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26182238
9.
Genomic-based high throughput screening identifies small molecules that differentially inhibit the antiviral and immunomodulatory effects of IFN-alpha.
Mol Med
; 14(7-8): 374-82, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18475307