Detalhe da pesquisa
1.
Contributing to the Revolution of Electrolyte Systems via In Situ Polymerization at Different Scales: A Review.
Small
; 20(1): e2305322, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37641186
2.
Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.
Bioorg Med Chem
; 101: 117609, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38364599
3.
Design, synthesis, and biological evaluation of novel donepezil-tacrine hybrids as multi-functional agents with low neurotoxicity against Alzheimer's disease.
Bioorg Chem
; 143: 107010, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38056387
4.
Stereoselective Synthesis of Substituted (Z)-N-Allyl Sulfonamides via a Palladium-Catalyzed Three-Component Tandem Reaction.
J Org Chem
; 88(7): 4162-4171, 2023 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36971317
5.
Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kα selective inhibitors.
Bioorg Chem
; 130: 106211, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343598
6.
Design, synthesis, and evaluation of hydrazones as dual inhibitors of ryanodine receptors and acetylcholinesterases for Alzheimer's disease.
Bioorg Chem
; 133: 106432, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36841050
7.
Structure-based drug design, synthesis, and biological evaluation of novel 1,3,5-triazine or pyrimidine derivatives containing benzoyl hydrazine moiety as PI3Kα selective inhibitors.
Bioorg Chem
; 140: 106738, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37562315
8.
2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia.
Bioorg Chem
; 134: 106442, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36878064
9.
Discovery of 4-phenylindolines containing a (5-cyanopyridin-3-yl)methoxy moiety as potent inhibitors of the PD-1/PD-L1 interaction.
Bioorg Med Chem Lett
; 63: 128647, 2022 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35231577
10.
Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors.
Bioorg Med Chem Lett
; 70: 128805, 2022 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35598794
11.
Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents.
Bioorg Chem
; 120: 105629, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35078047
12.
Discovery of benzamide derivatives containing urea moiety as soluble epoxide hydrolase inhibitors.
Bioorg Chem
; 127: 105898, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35792317
13.
Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety.
Bioorg Med Chem Lett
; 32: 127660, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33144245
14.
Insights into non-peptide small-molecule inhibitors of the PD-1/PD-L1 interaction: Development and perspective.
Bioorg Med Chem
; 33: 116038, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33517226
15.
Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors.
Bioorg Med Chem Lett
; 30(23): 127610, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33045329
16.
Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors.
Bioorg Med Chem Lett
; 30(16): 127329, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631534
17.
Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity.
Bioorg Med Chem
; 28(11): 115486, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32305182
18.
Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents.
Bioorg Chem
; 99: 103796, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32283346
19.
Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition.
Bioorg Chem
; 104: 104197, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32927132
20.
Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3).
Bioorg Chem
; 104: 104361, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33142418