Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Lipidomic profiling of rat hepatic stellate cells during activation reveals a two-stage process accompanied by increased levels of lysosomal lipids.

Molenaar, Martijn R; Haaker, Maya W; Vaandrager, A Bas; Houweling, Martin; Helms, J Bernd.

J Biol Chem ; 299(4): 103042, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36803964

2.

Inhibition of polyploidization in Pten-deficient livers reduces steatosis.

Moreno, Eva; Matondo, Augustine B; Bongiovanni, Laura; van de Lest, Chris H A; Molenaar, Martijn R; Toussaint, Mathilda J M; van Essen, Saskia C; Houweling, Martin; Helms, J Bernd; Westendorp, Bart; de Bruin, Alain.

Liver Int ; 42(11): 2442-2452, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35924448

3.

Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.

Tuohetahuntila, Maidina; Molenaar, Martijn R; Spee, Bart; Brouwers, Jos F; Wubbolts, Richard; Houweling, Martin; Yan, Cong; Du, Hong; VanderVen, Brian C; Vaandrager, Arie B; Helms, J Bernd.

J Biol Chem ; 292(30): 12436-12448, 2017 07 28.

Artigo em Inglês | MEDLINE | ID: mdl-28615446

4.

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.

Massafra, Vittoria; Milona, Alexandra; Vos, Harmjan R; Ramos, Rúben J J; Gerrits, Johan; Willemsen, Ellen C L; Ramos Pittol, José M; Ijssennagger, Noortje; Houweling, Martin; Prinsen, Hubertus C M T; Verhoeven-Duif, Nanda M; Burgering, Boudewijn M T; van Mil, Saskia W C.

Gastroenterology ; 152(6): 1462-1476.e10, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28130067

5.

Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT.

Ajat, Mokrish; Molenaar, Martijn; Brouwers, Jos F H M; Vaandrager, Arie B; Houweling, Martin; Helms, J Bernd.

Biochim Biophys Acta Mol Cell Biol Lipids ; 1862(2): 176-187, 2017 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-27815220

6.

ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.

Tuohetahuntila, Maidina; Molenaar, Martijn R; Spee, Bart; Brouwers, Jos F; Houweling, Martin; Vaandrager, Arie B; Helms, J Bernd.

J Lipid Res ; 57(7): 1162-74, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27179362

7.

Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells.

Tuohetahuntila, Maidina; Spee, Bart; Kruitwagen, Hedwig S; Wubbolts, Richard; Brouwers, Jos F; van de Lest, Chris H; Molenaar, Martijn R; Houweling, Martin; Helms, J Bernd; Vaandrager, Arie B.

Biochim Biophys Acta ; 1851(2): 220-30, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25500141

8.

Retinyl esters form lipid droplets independently of triacylglycerol and seipin.

Molenaar, Martijn R; Yadav, Kamlesh K; Toulmay, Alexandre; Wassenaar, Tsjerk A; Mari, Muriel C; Caillon, Lucie; Chorlay, Aymeric; Lukmantara, Ivan E; Haaker, Maya W; Wubbolts, Richard W; Houweling, Martin; Vaandrager, Arie Bas; Prieur, Xavier; Reggiori, Fulvio; Choudhary, Vineet; Yang, Hongyuan; Schneiter, Roger; Thiam, Abdou Rachid; Prinz, William A; Helms, J Bernd.

J Cell Biol ; 220(10)2021 10 04.

Artigo em Inglês | MEDLINE | ID: mdl-34323918

9.

A mono-acyl phospholipid (20:1 lyso-PS) activates Toll-Like Receptor 2/6 hetero-dimer.

Bexkens, Michiel L; Houweling, Martin; Burgers, Peter C; Luider, Theo M; Tielens, Aloysius G M; van Hellemond, Jaap J.

Chem Phys Lipids ; 232: 104951, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32795466

10.

Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system.

Haaker, Maya W; Kruitwagen, Hedwig S; Vaandrager, Arie B; Houweling, Martin; Penning, Louis C; Molenaar, Martijn R; van Wolferen, Monique E; Oosterhoff, Loes A; Spee, Bart; Helms, J Bernd.

J Vet Intern Med ; 34(1): 132-138, 2020 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-31830357

11.

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex.

Testerink, Nicole; van der Sanden, Michiel H M; Houweling, Martin; Helms, J Bernd; Vaandrager, Arie B.

J Lipid Res ; 50(11): 2182-92, 2009 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-19458387

12.

Schistosoma mansoni does not and cannot oxidise fatty acids, but these are used for biosynthetic purposes instead.

Bexkens, Michiel L; Mebius, Mirjam M; Houweling, Martin; Brouwers, Jos F; Tielens, Aloysius G M; van Hellemond, Jaap J.

Int J Parasitol ; 49(8): 647-656, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31170410

13.

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.

Haberkant, Per; Raijmakers, Reinout; Wildwater, Marjolein; Sachsenheimer, Timo; Brügger, Britta; Maeda, Kenji; Houweling, Martin; Gavin, Anne-Claude; Schultz, Carsten; van Meer, Gerrit; Heck, Albert J R; Holthuis, Joost C M.

Angew Chem Int Ed Engl ; 52(14): 4033-8, 2013 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-23450850

14.

Phosphatidylcholine and cell death.

Cui, Zheng; Houweling, Martin.

Biochim Biophys Acta ; 1585(2-3): 87-96, 2002 Dec 30.

Artigo em Inglês | MEDLINE | ID: mdl-12531541

15.

Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis.

van der Sanden, Michiel H M; Houweling, Martin; Duijsings, Daniël; Vaandrager, Arie B; van Golde, Lambert M G.

Biochim Biophys Acta ; 1636(2-3): 99-107, 2004 Mar 22.

Artigo em Inglês | MEDLINE | ID: mdl-15164757

16.

Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.

Bleijerveld, Onno B; Klein, Wil; Vaandrager, Arie B; Helms, J Bernd; Houweling, Martin.

Biochem J ; 379(Pt 3): 711-9, 2004 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-14759225

17.

Effects of a single glucocorticoid injection on propylene glycol-treated cows with clinical ketosis.

van der Drift, Saskia G A; Houweling, Martin; Bouman, Marina; Koets, Ad P; Tielens, Aloysius G M; Nielen, Mirjam; Jorritsma, Ruurd.

Vet J ; 204(2): 144-9, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25841896

18.

Hexadecylphosphocholine causes rapid cell death in canine mammary tumour cells.

Duijsings, Daniël; Houweling, Martin; Vaandrager, Arie B; Mol, Jan A; Teerds, Katja J.

Eur J Pharmacol ; 502(3): 185-93, 2004 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-15476744

19.

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.

Smolders, Lucas A; Meij, Björn P; Onis, David; Riemers, Frank M; Bergknut, Niklas; Wubbolts, Richard; Grinwis, Guy C M; Houweling, Martin; Groot Koerkamp, Marian J A; van Leenen, Dik; Holstege, Frank C P; Hazewinkel, Herman A W; Creemers, Laura B; Penning, Louis C; Tryfonidou, Marianna A.

Arthritis Res Ther ; 15(1): R23, 2013 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-23360510

20.

The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p.

De Smet, Cedric H; Vittone, Elisa; Scherer, Max; Houweling, Martin; Liebisch, Gerhard; Brouwers, Jos F; de Kroon, Anton I P M.

Mol Biol Cell ; 23(7): 1146-56, 2012 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-22323296

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