Detalhe da pesquisa
1.
Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.
PLoS Pathog
; 20(2): e1012007, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38386661
2.
Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.
PLoS Biol
; 21(12): e3002249, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38127878
3.
In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat.
Mem Inst Oswaldo Cruz
; 118: e230056, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37436275
4.
Oral Tecovirimat for the Treatment of Smallpox.
N Engl J Med
; 379(1): 44-53, 2018 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29972742
5.
Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques.
J Infect Dis
; 218(9): 1490-1499, 2018 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29982575
6.
Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
Antimicrob Agents Chemother
; 59(7): 4296-300, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896687
7.
ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.
J Antimicrob Chemother
; 70(5): 1367-80, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630650
8.
The broad-spectrum antiviral compound ST-669 restricts chlamydial inclusion development and bacterial growth and localizes to host cell lipid droplets within treated cells.
Antimicrob Agents Chemother
; 58(7): 3860-6, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24777097
9.
Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).
Antimicrob Agents Chemother
; 57(12): 6246-53, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100494
10.
Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.
Antimicrob Agents Chemother
; 57(3): 1136-43, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23254433
11.
A novel inhibitor of dengue virus replication that targets the capsid protein.
Antimicrob Agents Chemother
; 57(1): 15-25, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23070172
12.
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Antimicrob Agents Chemother
; 57(4): 1902-12, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403421
13.
Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus.
Bioorg Med Chem Lett
; 23(21): 5840-3, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24064500
14.
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles.
Bioorg Med Chem Lett
; 23(3): 750-6, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265900
15.
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole.
Bioorg Med Chem Lett
; 23(3): 744-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265895
16.
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Proc Natl Acad Sci U S A
; 107(2): 838-43, 2010 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080762
17.
Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001.
J Infect Dis
; 206(9): 1372-85, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22904336
18.
Emerging pharmacological strategies for treating and preventing mpox.
Expert Rev Clin Pharmacol
; 16(9): 843-854, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592723
19.
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential.
Expert Rev Anti Infect Ther
; 21(3): 235-242, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36728515
20.
Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.
Antimicrob Agents Chemother
; 56(8): 4296-302, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22644029