1.
Bioorg Med Chem Lett
; 18(17): 4885-90, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18678488
RESUMO
The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors.