Detalhe da pesquisa
1.
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Bioorg Med Chem
; 26(11): 2937-2957, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29776834
2.
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787.
J Med Chem
; 2024 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38866424
3.
Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.
J Med Chem
; 66(23): 15728-15749, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967462
4.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
J Med Chem
; 65(22): 15174-15207, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36378954
5.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34995458
6.
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
ACS Med Chem Lett
; 12(8): 1308-1317, 2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413961
7.
Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi.
ACS Infect Dis
; 7(8): 2238-2249, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33203208
8.
Alkene Syn- and Anti-Oxyamination with Malonoyl Peroxides.
Org Lett
; 22(4): 1659-1664, 2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31999132
9.
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
J Med Chem
; 63(11): 5816-5840, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32410449
10.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
J Med Chem
; 63(2): 714-746, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904959
11.
Advancements in the Development of non-BET Bromodomain Chemical Probes.
ChemMedChem
; 14(4): 362-385, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624862
12.
Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization.
J Am Chem Soc
; 130(15): 5368-77, 2008 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18303837
13.
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach.
ACS Chem Biol
; 13(10): 2862-2867, 2018 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30200762
14.
Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
J Med Chem
; 60(2): 695-709, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002667
15.
Intramolecular cyclopropanation of unsaturated terminal aziridines.
Org Lett
; 8(5): 995-8, 2006 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16494493
16.
Clinical progress and pharmacology of small molecule bromodomain inhibitors.
Curr Opin Chem Biol
; 33: 58-66, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27295577
17.
Progress in the Development of non-BET Bromodomain Chemical Probes.
ChemMedChem
; 11(5): 477-87, 2016 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26749027
18.
Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics.
ACS Chem Biol
; 11(7): 2002-10, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27197014
19.
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
J Med Chem
; 59(4): 1370-87, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26771203
20.
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
J Med Chem
; 59(4): 1425-39, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25856009